Pik3c3 - phosphatidylinositol 3-kinase catalytic subunit type 3 Gene

Mus musculus

Also known as Vps34; 5330434F23Rik

Gene ID: 225326 | Gene type: protein coding

About Pik3c3

Chromosome 18: 30,405,800-30,481,179 forward strand.GRCm39:CM001011.3

This gene has 4 transcripts (splice variants), 210 orthologues, 9 paralogues and is associated with 19 phenotypes. Broad expression in CNS E14 (RPKM 15.), CNS E18 (RPKM 11.) and 24 other tissues.

Summary

Enables protein kinase activity. Involved in cellular response to glucose starvation and macroautophagy. Acts upstream of or within several processes, including cellular response to starvation; phosphatidylinositol-3-phosphate biosynthetic process; and protein localization to phagophore assembly site. Located in phagocytic vesicle. Part of phosphatidylinositol 3-kinase complex, class III. Is expressed in Meckel's cartilage; cardiovascular system; limb; and skeleton. Orthologous to human PIK3C3 (phosphatidylinositol 3-kinase catalytic subunit type 3). [provided by Alliance of Genome Resources, Apr 2022]

Pik3c3 Products(1)

mRNA	Protein	Name
NM_181414.6	NP_852079.2	phosphatidylinositol 3-kinase catalytic subunit type 3

Pik3c3 Protein Structure

C2_PI3K_class_III

PI3Ka_III

PI3Kc_III

0
200
400
600
800
887 a.a.

Protein Preferred Names

Protein Names

phosphatidylinositol 3-kinase catalytic subunit type 3

PI3-kinase type 3	PI3K type 3
phosphoinositide-3-kinase, class 3	ptdIns-3-kinase type 3

Related Agents

Pre-clinical Phase

Bioactive Molecules (6)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-12481	SAR405	Inhibitor	98.99%	Unkown
HY-137506	XST-14		99.69%	Unkown
HY-12481A	SAR405 R enantiomer		99.78%	Unkown
HY-RS10520	PIK3C3 Human Pre-designed siRNA Set A		/	Unkown
HY-RS10521	Pik3c3 Mouse Pre-designed siRNA Set A		/	Unkown
HY-RS10522	Pik3c3 Rat Pre-designed siRNA Set A		/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Pik3c3	NCBI	NCBI:5289

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