Pik3c3 - phosphatidylinositol 3-kinase catalytic subunit type 3 Gene

Also Known as Vps34; 5330434F23Rik

Species: Mus musculus

Gene Type: protein coding

Gene ID: 225326

About Pik3c3

Chromosome 18: 30,405,800-30,481,179 forward strand.GRCm39:CM001011.3

This gene has 4 transcripts (splice variants), 210 orthologues, 9 paralogues and is associated with 19 phenotypes. Broad expression in CNS E14 (RPKM 15.), CNS E18 (RPKM 11.) and 24 other tissues.

Summary

Enables protein kinase activity. Involved in cellular response to glucose starvation and macroautophagy. Acts upstream of or within several processes, including cellular response to starvation; phosphatidylinositol-3-phosphate biosynthetic process; and protein localization to phagophore assembly site. Located in phagocytic vesicle. Part of phosphatidylinositol 3-kinase complex, class III. Is expressed in Meckel's cartilage; cardiovascular system; limb; and skeleton. Orthologous to human PIK3C3 (phosphatidylinositol 3-kinase catalytic subunit type 3). [provided by Alliance of Genome Resources, Apr 2022]

Pik3c3 Products (1)

mRNA	Protein	Name
NM_181414.6	NP_852079.2	phosphatidylinositol 3-kinase catalytic subunit type 3

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables protein binding	IPI IPI: Inferred from physical interaction	22493499	MGI
enables protein kinase activity	IMP IMP: Inferred from mutant phenotype	15010863	MGI

Biological Process GO Annotation	Evidence	References	Source
acts upstream of or within autophagosome assembly	IMP IMP: Inferred from mutant phenotype	24098492	MGI
involved in cellular response to glucose starvation	IDA IDA: Inferred from direct assay	23332761	MGI
acts upstream of or within cellular response to starvation	IMP IMP: Inferred from mutant phenotype	24098492	MGI
involved in macroautophagy	IMP IMP: Inferred from mutant phenotype	23332761	MGI
acts upstream of or within phosphatidylinositol-3-phosphate biosynthetic process	IMP IMP: Inferred from mutant phenotype	24098492	MGI
acts upstream of or within protein localization to phagophore assembly site	IMP IMP: Inferred from mutant phenotype	24098492	MGI
acts upstream of or within protein phosphorylation	IMP IMP: Inferred from mutant phenotype	15010863	MGI
involved in synaptic vesicle endocytosis	EXP EXP: Inferred from Experiment	35318705	MGI
involved in synaptic vesicle endocytosis	IDA IDA: Inferred from direct assay	35318705	MGI
involved in synaptic vesicle endocytosis	IEP IEP: Inferred from expression pattern	35318705	MGI

Cellular Component GO Annotation	Evidence	References	Source
is active in GABA-ergic synapse	IDA IDA: Inferred from direct assay	35318705	MGI
is active in GABA-ergic synapse	IMP IMP: Inferred from mutant phenotype	35318705	MGI
is active in glutamatergic synapse	IDA IDA: Inferred from direct assay	35318705	MGI
is active in glutamatergic synapse	IMP IMP: Inferred from mutant phenotype	35318705	MGI
located in phagocytic vesicle	IDA IDA: Inferred from direct assay	22493499	MGI
part of phosphatidylinositol 3-kinase complex, class III	IDA IDA: Inferred from direct assay	23332761	MGI
is active in postsynapse	IDA IDA: Inferred from direct assay	20955765	MGI
is active in postsynapse	IMP IMP: Inferred from mutant phenotype	20955765	MGI
is active in postsynaptic endosome	IDA IDA: Inferred from direct assay	35318705	MGI
is active in postsynaptic endosome	IMP IMP: Inferred from mutant phenotype	35318705	MGI
is active in presynaptic endosome	IDA IDA: Inferred from direct assay	35318705	MGI
is active in presynaptic endosome	IMP IMP: Inferred from mutant phenotype	35318705	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Pik3c3 Protein Structure

C2_PI3K_class_III

PI3Ka_III

PI3Kc_III

0
200
400
600
800
887 a.a.

Protein Preferred Names	Protein Names
phosphatidylinositol 3-kinase catalytic subunit type 3	PI3-kinase type 3 PI3K type 3 phosphoinositide-3-kinase, class 3 ptdIns-3-kinase type 3

Pik3c3 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	Pik3c3	Q6PF93	Becn1	Mus musculus	O88597	Anti Bait CoIP	23332761
Intra	Pik3c3	Q6PF93	Becn1	Mus musculus	O88597	Anti Bait CoIP	23974797
Intra	Pik3c3	Q6PF93	Becn1	Mus musculus	O88597	Anti Bait CoIP	24849286

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (8)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-12481	SAR405	Inhibitor	99.74%	Unkown
HY-137506	XST-14		99.26%	Unkown
HY-12481A	SAR405 R enantiomer	Control	99.94%	Unkown
HY-RS10521	Pik3c3 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-122888	MPT0L145		/	Unkown
HY-181062	VWK147		/	Unkown
HY-RS10520	PIK3C3 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS10522	Pik3c3 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Pik3c3	NCBI	NCBI:5289