PIK3C3
VPS34, encoded by PIK3C3, is the only class III phosphoinositide 3-kinase in mammals and the sole enzyme dedicated to producing PI3P from phosphatidylinositol. It assembles into distinct complexes with the regulatory subunit VPS15 and with Beclin 1 together with either ATG14 or UVRAG, which direct it to autophagic or endosomal membranes. Through localized PI3P synthesis, VPS34 nucleates autophagosome formation, drives endosome-to-Golgi trafficking and supports receptor sorting. Its central position in autophagy makes VPS34 a tool and target for compounds such as wortmannin and VPS34-IN1, and it is studied in cancer, neurodegeneration and infection.
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PIK3C3 Recombinant Proteins (1)
- Species:
- Source:
Recombinant Protein Expression Service
- Codon Optimization
- Gene Synthesis
- Construction of Expression Vector
- Strain Screening
- Protein Expression
- Purification & QC
- Protein Delivery
- Formula: Human
- Molecular Weight: Sf9 insect cells
The EpCAM/TROP1 protein serves as an important homogeneous interacting molecule that promotes direct contact between intestinal epithelial cells (IEC) and intraepithelial lymphocytes (IEL) in the mucosal epithelium. This feature helps establish an immune barrier against mucosal infections. EpCAM/TROP1 Protein, Human (His-SUMO) is the recombinant human-derived EpCAM/TROP1 protein, expressed by E. coli , with N-6*His, N-SUMO labeled tag.
