Adar - adenosine deaminase, RNA-specific Gene

Also Known as Adar1; DRADA; mZaADAR; Adar1p110; Adar1p150

Species: Mus musculus

Gene Type: protein coding
Gene ID: 56417

Summary

Enables double-stranded RNA Adenosine Deaminase activity. Involved in several processes, including adenosine to inosine editing; negative regulation of protein kinase activity by regulation of protein phosphorylation; and positive regulation of viral genome replication. Acts upstream of or within several processes, including hematopoietic stem cell homeostasis; immune system development; and regulation of gene expression. Located in cytoplasm and nucleolus. Is expressed in several structures, including alimentary system; central nervous system; genitourinary system; integumental system; and sensory organ. Human ortholog(s) of this gene implicated in Aicardi-Goutieres syndrome; Human papillomavirus infectious disease; dyschromatosis symmetrica hereditaria; and liver cirrhosis. Orthologous to human ADAR (Adenosine Deaminase RNA specific). [provided by Alliance of Genome Resources, Apr 2022]

Adar Products (11)

mRNA Protein Name
NM_001038587.5 NP_001033676.2 double-stranded RNA-specific adenosine deaminase isoform 2
NM_001146296.2 NP_001139768.1 double-stranded RNA-specific adenosine deaminase isoform 3
NM_001357958.2 NP_001344887.1 double-stranded RNA-specific adenosine deaminase isoform 4
NM_001410658.1 NP_001397587.1 double-stranded RNA-specific adenosine deaminase isoform 5
NM_001410659.1 NP_001397588.1 double-stranded RNA-specific adenosine deaminase isoform 2
NM_001410660.1 NP_001397589.1 double-stranded RNA-specific adenosine deaminase isoform 6
NM_001410661.1 NP_001397590.1 double-stranded RNA-specific adenosine deaminase isoform 7
NM_001410662.1 NP_001397591.1 double-stranded RNA-specific adenosine deaminase isoform 8
NM_001410663.1 NP_001397592.1 double-stranded RNA-specific adenosine deaminase isoform 9
NM_001410664.1 NP_001397593.1 double-stranded RNA-specific adenosine deaminase isoform 9
NM_019655.4 NP_062629.3 double-stranded RNA-specific adenosine deaminase isoform 1

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
18362360 MGI
Biological Process GO Annotation Evidence References Source
involved in adenosine to inosine editing IDA
IDA: Inferred from direct assay
17369310 MGI
acts upstream of or within adenosine to inosine editing IMP
IMP: Inferred from mutant phenotype
14615479 MGI
acts upstream of apoptotic process IMP
IMP: Inferred from mutant phenotype
14613934 MGI
involved in cellular response to virus IDA
IDA: Inferred from direct assay
24882218 MGI
acts upstream of or within definitive hemopoiesis IMP
IMP: Inferred from mutant phenotype
14615479 MGI
acts upstream of or within erythrocyte differentiation IMP
IMP: Inferred from mutant phenotype
11099415 MGI
acts upstream of or within hematopoietic progenitor cell differentiation IMP
IMP: Inferred from mutant phenotype
19805087 MGI
acts upstream of or within hematopoietic stem cell homeostasis IMP
IMP: Inferred from mutant phenotype
19060901 MGI
acts upstream of hepatocyte apoptotic process IMP
IMP: Inferred from mutant phenotype
14613934 MGI
acts upstream of or within miRNA processing IMP
IMP: Inferred from mutant phenotype
23622242 MGI
acts upstream of or within negative regulation of hepatocyte apoptotic process IMP
IMP: Inferred from mutant phenotype
14613934 MGI
acts upstream of or within negative regulation of post-transcriptional gene silencing by regulatory ncRNA IMP
IMP: Inferred from mutant phenotype
15556947 MGI
involved in negative regulation of protein kinase activity by regulation of protein phosphorylation IMP
IMP: Inferred from mutant phenotype
18362360 MGI
acts upstream of or within negative regulation of type I interferon-mediated signaling pathway IMP
IMP: Inferred from mutant phenotype
19060901 MGI
acts upstream of or within osteoblast differentiation IMP
IMP: Inferred from mutant phenotype
23123729 MGI
involved in positive regulation of viral genome replication IMP
IMP: Inferred from mutant phenotype
18362360 MGI
acts upstream of or within somatic diversification of immune receptors via somatic mutation IDA
IDA: Inferred from direct assay
23209284 MGI
Cellular Component GO Annotation Evidence References Source
located in cytoplasm IDA
IDA: Inferred from direct assay
14613934 MGI
located in nucleolus IDA
IDA: Inferred from direct assay
14613934 MGI
located in nucleus IDA
IDA: Inferred from direct assay
14613934 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

double-stranded RNA-specific adenosine deaminase

  • RNA adenosine deaminase 1

  • RNA-specific adenosine deaminase p110 form

  • RNA-specific adenosine deaminase p150 form

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (8)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-115686 8-Azaadenosine Inhibitor 99.94% Unkown
HY-145443 Fludarabine-Cl Inhibitor 99.71% Unkown
HY-181129 ADAR1i-124 98.71% Unkown
HY-145442 8-Azanebularine Inhibitor 99.33% Unkown
HY-175243 ADAR1-IN-1 98.18% Unkown
HY-RS00317 ADAR Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS17682 Adar Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS24143 Adar Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Adar NCBI NCBI:103