USP28 - ubiquitin specific peptidase 28 Gene

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 57646

About USP28

Cytogenetic location: 11q23.2 Genomic coordinates (GRCh38): 11:113,797,875-113,875,572 (from NCBI)

This gene has 17 transcripts (splice variants), 208 orthologues and 71 paralogues. Ubiquitous expression in heart (RPKM 11.8), lymph node (RPKM 4.2) and 24 other tissues.

Summary

The protein encoded by this gene is a Deubiquitinase involved in the DNA damage pathway and DNA damage-induced Apoptosis. Overexpression of this gene is seen in several cancers. [provided by RefSeq, Oct 2016]

USP28 Products (50)

mRNA Protein Name
NM_001301029.2 NP_001287958.1 ubiquitin carboxyl-terminal hydrolase 28 isoform b
NM_001346252.4 NP_001333181.1 ubiquitin carboxyl-terminal hydrolase 28 isoform c
NM_001346253.2 NP_001333182.1 ubiquitin carboxyl-terminal hydrolase 28 isoform d
NM_001346254.2 NP_001333183.1 ubiquitin carboxyl-terminal hydrolase 28 isoform e
NM_001346255.2 NP_001333184.1 ubiquitin carboxyl-terminal hydrolase 28 isoform f
NM_001346257.2 NP_001333186.1 ubiquitin carboxyl-terminal hydrolase 28 isoform g
NM_001346258.2 NP_001333187.1 ubiquitin carboxyl-terminal hydrolase 28 isoform h
NM_001346259.2 NP_001333188.1 ubiquitin carboxyl-terminal hydrolase 28 isoform i
NM_001346260.2 NP_001333189.1 ubiquitin carboxyl-terminal hydrolase 28 isoform j
NM_001346261.2 NP_001333190.1 ubiquitin carboxyl-terminal hydrolase 28 isoform k
NM_001346262.2 NP_001333191.1 ubiquitin carboxyl-terminal hydrolase 28 isoform b
NM_001346263.2 NP_001333192.1 ubiquitin carboxyl-terminal hydrolase 28 isoform l
NM_001346264.2 NP_001333193.1 ubiquitin carboxyl-terminal hydrolase 28 isoform m
NM_001346265.2 NP_001333194.1 ubiquitin carboxyl-terminal hydrolase 28 isoform n
NM_001346267.2 NP_001333196.1 ubiquitin carboxyl-terminal hydrolase 28 isoform o
NM_001346268.2 NP_001333197.1 ubiquitin carboxyl-terminal hydrolase 28 isoform o
NM_001346269.2 NP_001333198.1 ubiquitin carboxyl-terminal hydrolase 28 isoform p
NM_001346270.2 NP_001333199.1 ubiquitin carboxyl-terminal hydrolase 28 isoform p
NM_001346271.2 NP_001333200.1 ubiquitin carboxyl-terminal hydrolase 28 isoform p
NM_001346272.2 NP_001333201.1 ubiquitin carboxyl-terminal hydrolase 28 isoform q
NM_001346273.2 NP_001333202.1 ubiquitin carboxyl-terminal hydrolase 28 isoform r
NM_001400784.1 NP_001387713.1 ubiquitin carboxyl-terminal hydrolase 28 isoform 20
NM_001400785.1 NP_001387714.1 ubiquitin carboxyl-terminal hydrolase 28 isoform 21
NM_001400786.1 NP_001387715.1 ubiquitin carboxyl-terminal hydrolase 28 isoform 22
NM_001400787.1 NP_001387716.1 ubiquitin carboxyl-terminal hydrolase 28 isoform 23
NM_001400788.1 NP_001387717.1 ubiquitin carboxyl-terminal hydrolase 28 isoform 24
NM_001400789.1 NP_001387718.1 ubiquitin carboxyl-terminal hydrolase 28 isoform 25
NM_001400790.1 NP_001387719.1 ubiquitin carboxyl-terminal hydrolase 28 isoform 26
NM_001400791.1 NP_001387720.1 ubiquitin carboxyl-terminal hydrolase 28 isoform 27
NM_001400792.1 NP_001387721.1 ubiquitin carboxyl-terminal hydrolase 28 isoform 28
NM_001400793.1 NP_001387722.1 ubiquitin carboxyl-terminal hydrolase 28 isoform 29
NM_001400794.1 NP_001387723.1 ubiquitin carboxyl-terminal hydrolase 28 isoform 30
NM_001400795.1 NP_001387724.1 ubiquitin carboxyl-terminal hydrolase 28 isoform 31
NM_001400796.1 NP_001387725.1 ubiquitin carboxyl-terminal hydrolase 28 isoform 31
NM_001400797.1 NP_001387726.1 ubiquitin carboxyl-terminal hydrolase 28 isoform 33
NM_001400799.1 NP_001387728.1 ubiquitin carboxyl-terminal hydrolase 28 isoform 34
NM_001400800.1 NP_001387729.1 ubiquitin carboxyl-terminal hydrolase 28 isoform 35
NM_001400801.1 NP_001387730.1 ubiquitin carboxyl-terminal hydrolase 28 isoform 19
NM_001400802.1 NP_001387731.1 ubiquitin carboxyl-terminal hydrolase 28 isoform 19
NM_001400803.1 NP_001387732.1 ubiquitin carboxyl-terminal hydrolase 28 isoform 36
NM_001400804.1 NP_001387733.1 ubiquitin carboxyl-terminal hydrolase 28 isoform 36
NM_001400805.1 NP_001387734.1 ubiquitin carboxyl-terminal hydrolase 28 isoform 38
NM_001400806.1 NP_001387735.1 ubiquitin carboxyl-terminal hydrolase 28 isoform q
NM_001400807.1 NP_001387736.1 ubiquitin carboxyl-terminal hydrolase 28 isoform 35
NM_001400809.1 NP_001387738.1 ubiquitin carboxyl-terminal hydrolase 28 isoform 40
NM_001400810.1 NP_001387739.1 ubiquitin carboxyl-terminal hydrolase 28 isoform 41
NM_001400811.1 NP_001387740.1 ubiquitin carboxyl-terminal hydrolase 28 isoform 19
NM_001400812.1 NP_001387741.1 ubiquitin carboxyl-terminal hydrolase 28 isoform 42
NM_001400813.1 NP_001387742.1 ubiquitin carboxyl-terminal hydrolase 28 isoform 36
NM_020886.4 NP_065937.1 ubiquitin carboxyl-terminal hydrolase 28 isoform a

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables cysteine-type deubiquitinase activity IDA
IDA: Inferred from direct assay
16901786 GOA
enables cysteine-type deubiquitinase activity IMP
IMP: Inferred from mutant phenotype
16901786 GOA
enables deubiquitinase activity IMP
IMP: Inferred from mutant phenotype
24623306 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
16901786 GOA
Biological Process GO Annotation Evidence References Source
involved in DNA damage checkpoint signaling IMP
IMP: Inferred from mutant phenotype
18662541 GOA
involved in DNA damage response IDA
IDA: Inferred from direct assay
17873522 GOA
involved in cell population proliferation IMP
IMP: Inferred from mutant phenotype
17558397 GOA
involved in cellular response to UV IDA
IDA: Inferred from direct assay
17873522 GOA
involved in intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator IDA
IDA: Inferred from direct assay
16901786 GOA
involved in protein deubiquitination IDA
IDA: Inferred from direct assay
16901786 GOA
involved in protein deubiquitination involved in ubiquitin-dependent protein catabolic process IMP
IMP: Inferred from mutant phenotype
24623306 GOA
involved in regulation of protein stability IMP
IMP: Inferred from mutant phenotype
24623306 GOA
involved in response to ionizing radiation IDA
IDA: Inferred from direct assay
16901786 GOA
Cellular Component GO Annotation Evidence References Source
located in nucleoplasm IDA
IDA: Inferred from direct assay
17558397 GOA
part of protein-containing complex IDA
IDA: Inferred from direct assay
17873522 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

USP28 Protein Structure

UCH

UCH: Ubiquitin carboxyl-terminal hydrolase (161 - 647)

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  • 1077 a.a.
Protein Preferred Names Protein Names

ubiquitin carboxyl-terminal hydrolase 28

  • deubiquitinating enzyme 28

USP28 Antibodies

Cat. No. Product Name Application Reactivity
HY-P81591 USP28 Antibody (YA1336) WB, ICC/IF, FC Human

Related Diseases

Diseases Alias
Colorectal Cancer

  • Colon Cancer

  • Colorectal Carcinoma

  • Colon Carcinoma

  • Colorectal Cancer, Susceptibility To

  • Carcinoma Of Colon

  • CRC

  • Colorectal Cancer With Chromosomal Instability, Somatic

  • Colon Cancer, Somatic

  • Colon Cancer, Susceptibility To

  • Colonic Neoplasms

  • Colorectal Neoplasms

  • Colorectal Cancer, Somatic

  • Colon Cancer, Advanced, Somatic

  • Colonic Carcinoma

  • Colorectal Carcinomas

  • Colon Cancers

  • Colorectal Cancers

  • Cancer, Colorectal, Somatic

  • Cancer, Colon

  • Cancer, Colorectal, Susceptibility To

  • Colorectal Neoplasm

  • Colonic Neoplasm

  • Malignant Tumor Of Colon
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-184244 CAS-010 Inhibitor / Unkown

Orthologs Information

Species Symbol Source ID
Mus musculus USP28 MGD MGI:2442293
Macaca mulatta USP28 VGNC VGNC:78745
Canis familiaris USP28 VGNC VGNC:48186
Bos taurus USP28 VGNC VGNC:36720
Rattus norvegicus USP28 RGD RGD:1311555
Felis catus USP28 VGNC VGNC:66876
Others USP28 NCBI