Fhl5 - four and a half LIM domains 5 Gene

Also Known as Act; 1700027G07Rik

Species: Mus musculus

Gene Type: protein coding
Gene ID: 57756

Summary

Enables transcription coactivator activity. Acts upstream of or within positive regulation of transcription by RNA polymerase II. Predicted to be active in Z disc and nucleus. Is expressed in genitourinary system; heart; and otocyst. Orthologous to human FHL5 (four and a half LIM domains 5). [provided by Alliance of Genome Resources, Apr 2022]

Fhl5 Products (3)

mRNA Protein Name
NM_001355498.2 NP_001342427.1 four and a half LIM domains protein 5
NM_001379528.1 NP_001366457.1 four and a half LIM domains protein 5
NM_021318.5 NP_067293.1 four and a half LIM domains protein 5

Gene Ontology

  • Molecular Function
  • Biological Process
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
20488182 MGI
enables transcription coactivator activity IDA
IDA: Inferred from direct assay
10086359 MGI
Biological Process GO Annotation Evidence References Source
acts upstream of or within positive regulation of transcription by RNA polymerase II IGI
IGI: Inferred from genetic interaction
20488182 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

four and a half LIM domains protein 5

  • FHL-5

  • LIM-only protein ACT

  • activator of CREM in testis

  • activator of cAMP-responsive element modulator in testis

Fhl5 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
Fhl5 Q9WTX7 Spag8 Mus musculus Q3V0Q6
Pull Down
20488182
Intra
Fhl5 Q9WTX7 Spag8 Mus musculus Q3V0Q6
Anti Tag CoIP
20488182
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (4)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS04937 FHL5 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS13990 STXBP2 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS18613 Fhl5 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS25099 Fhl5 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Fhl5 NCBI NCBI:9457