Sh3kbp1 - SH3-domain kinase binding protein 1 Gene

Also Known as Ruk; IN85; Seta; Cin85; 1200007H22Rik; 1700125L08Rik; 5830464D22Rik

Species: Mus musculus

Gene Type: protein coding
Gene ID: 58194

Summary

Predicted to enable ubiquitin protein Ligase binding activity. Predicted to be involved in several processes, including actin filament organization; positive regulation of B cell activation; and regulation of cell shape. Predicted to act upstream of or within apoptotic process and endocytosis. Located in cell-cell junction and endocytic vesicle. Is expressed in embryo. Human ortholog(s) of this gene implicated in immunodeficiency 61. Orthologous to human SH3KBP1 (SH3 domain containing kinase binding protein 1). [provided by Alliance of Genome Resources, Apr 2022]

Sh3kbp1 Products (6)

mRNA Protein Name
NM_001135727.2 NP_001129199.1 SH3 domain-containing kinase-binding protein 1 isoform 1
NM_001135728.2 NP_001129200.1 SH3 domain-containing kinase-binding protein 1 isoform 3
NM_001290661.1 NP_001277590.1 SH3 domain-containing kinase-binding protein 1 isoform 4
NM_001290664.1 NP_001277593.1 SH3 domain-containing kinase-binding protein 1 isoform 4
NM_001374701.1 NP_001361630.1 SH3 domain-containing kinase-binding protein 1 isoform 5
NM_021389.6 NP_067364.2 SH3 domain-containing kinase-binding protein 1 isoform 2

Gene Ontology

  • Molecular Function
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
11152963 MGI
Cellular Component GO Annotation Evidence References Source
located in cell-cell junction IDA
IDA: Inferred from direct assay
23793062 MGI
located in endocytic vesicle IDA
IDA: Inferred from direct assay
21830225 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

SH3 domain-containing kinase-binding protein 1

  • Ruk(deltaA) protein

  • Ruk(h) protein

  • Ruk(l) protein

  • Ruk(m1) protein

  • Ruk(m3) protein

  • Ruk(t) protein

  • Ruk(xl) protein

  • SH3-containing, expressed in tumorigenic astrocytes

  • regulator of ubiquitous kinase

Sh3kbp1 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
Sh3kbp1 Q8R550 Dlg4 Mus musculus Q62108
Anti Bait CoIP
20551902
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS12841 SH3KBP1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Sh3kbp1 NCBI NCBI:30011