2. Gene
  3. TP53INP2 - tumor protein p53 inducible nuclear protein 2 Gene

TP53INP2 - tumor protein p53 inducible nuclear protein 2 Gene

  • Gene
  • Protein
  • Disease
  • Agent
  • Ortholog
Homo sapiens

Also known as DOR; PIGU; PINH; PIG-U; C20orf110; dJ1181N3.1

Gene ID: 58476 | Gene type: protein coding

About TP53INP2

Cytogenetic location: 20q11.22 Genomic coordinates (GRCh38): 20:34,704,344-34,713,436 (from NCBI)

This gene has 4 transcripts (splice variants), 187 orthologues and 1 paralogue. Ubiquitous expression in esophagus (RPKM 35.1), brain (RPKM 34.7) and 25 other tissues.

Summary

The protein encoded by this gene promotes Autophagy and is essential for proper autophagosome formation and processing. In addition, the encoded protein can enhance rDNA transcription by helping in the assembly of the POLR1/RNA polymerase I preinitiation complex. Finally, this protein serves as a transcriptional activator for some genes. [provided by RefSeq, Jul 2016]

TP53INP2 Products(4)

mRNA Protein Name
NM_001329429.2 NP_001316358.1 tumor protein p53-inducible nuclear protein 2
NM_001329430.2 NP_001316359.1 tumor protein p53-inducible nuclear protein 2
NM_001329431.2 NP_001316360.1 tumor protein p53-inducible nuclear protein 2
NM_021202.3 NP_067025.1 tumor protein p53-inducible nuclear protein 2

TP53INP2 Protein Structure

DOR

DOR: DOR family (28 - 217)

  • 0
  • 100
  • 200
  • 220 a.a.
Protein Preferred Names Protein Names

tumor protein p53-inducible nuclear protein 2

diabetes and obesity-regulated

Related Diseases

Diseases Alias
Branchiootorenal Syndrome 2

BOR2

Bor Syndrome 2

Branchiootorenal Dysplasia 2

Branchio-Oto-Renal Dysplasia 2

Branchio-Oto-Renal Syndrome Type 2

Branchiootorenal Syndrome, Type 2
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS14921 TP53INP2 Human Pre-designed siRNA Set A / Unkown

Orthologs Information

Species Symbol Source ID
Mus musculus TP53INP2 MGD MGI:1915978
Bos taurus TP53INP2 VGNC VGNC:36237
Macaca mulatta TP53INP2 VGNC VGNC:108068
Rattus norvegicus TP53INP2 RGD RGD:735085
Canis familiaris TP53INP2 VGNC VGNC:47726