TP53INP2 - tumor protein p53 inducible nuclear protein 2 Gene

Also Known as DOR; PIGU; PINH; PIG-U; C20orf110; dJ1181N3.1

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 58476

About TP53INP2

Cytogenetic location: 20q11.22 Genomic coordinates (GRCh38): 20:34,704,344-34,713,436 (from NCBI)

This gene has 4 transcripts (splice variants), 187 orthologues and 1 paralogue. Ubiquitous expression in esophagus (RPKM 35.1), brain (RPKM 34.7) and 25 other tissues.

Summary

The protein encoded by this gene promotes Autophagy and is essential for proper autophagosome formation and processing. In addition, the encoded protein can enhance rDNA transcription by helping in the assembly of the POLR1/RNA polymerase I preinitiation complex. Finally, this protein serves as a transcriptional activator for some genes. [provided by RefSeq, Jul 2016]

TP53INP2 Products (4)

mRNA Protein Name
NM_001329429.2 NP_001316358.1 tumor protein p53-inducible nuclear protein 2
NM_001329430.2 NP_001316359.1 tumor protein p53-inducible nuclear protein 2
NM_001329431.2 NP_001316360.1 tumor protein p53-inducible nuclear protein 2
NM_021202.3 NP_067025.1 tumor protein p53-inducible nuclear protein 2

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Verweise Source
enables protein binding IPI
IPI: Inferred from physical interaction
19056683 GOA
Biological Process GO Annotation Evidence Verweise Source
involved in autophagosome assembly IDA
IDA: Inferred from direct assay
19056683 GOA
involved in positive regulation of DNA-templated transcription IDA
IDA: Inferred from direct assay
22470510 GOA
Cellular Component GO Annotation Evidence Verweise Source
located in autophagosome IDA
IDA: Inferred from direct assay
19056683 GOA
located in cytosol IDA
IDA: Inferred from direct assay
22470510 GOA
located in nucleus IDA
IDA: Inferred from direct assay
19056683 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

TP53INP2 Protein Structure

DOR

DOR: DOR family (28 - 217)

  • 0
  • 100
  • 200
  • 220 a.a.
Protein Preferred Names Protein Names

tumor protein p53-inducible nuclear protein 2

  • diabetes and obesity-regulated

Related Diseases

Diseases Alias
Branchiootorenal Syndrome 2

  • BOR2

  • Bor Syndrome 2

  • Branchiootorenal Dysplasia 2

  • Branchio-Oto-Renal Dysplasia 2

  • Branchio-Oto-Renal Syndrome Type 2

  • Branchiootorenal Syndrome, Type 2
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Art. -Nr. Produktname
Wirkung
Reinheit
Rare Diseases
HY-RS14921 TP53INP2 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Mus musculus TP53INP2 MGD MGI:1915978
Bos taurus TP53INP2 VGNC VGNC:36237
Macaca mulatta TP53INP2 VGNC VGNC:108068
Rattus norvegicus TP53INP2 RGD RGD:735085
Canis familiaris TP53INP2 VGNC VGNC:47726
Others TP53INP2 NCBI