Dlc1 - DLC1 Rho GTPase activating protein Gene

Also Known as RhoGAP; Arhgap7

Species: Rattus norvegicus

Gene Type: protein coding
Gene ID: 58834

Summary

Enables GTPase activator activity; Phospholipase binding activity; and vinculin binding activity. Involved in activation of Phospholipase C activity; cellular response to Insulin stimulus; and Cytoskeleton organization. Located in membrane raft. Colocalizes with actin filament; focal adhesion; and stress fiber. Human ortholog(s) of this gene implicated in colorectal Cancer. Orthologous to human DLC1 (DLC1 Rho GTPase activating protein). [provided by Alliance of Genome Resources, Apr 2022]

Dlc1 Products (2)

mRNA Protein Name
NM_001127446.1 NP_001120918.1 rho GTPase-activating protein 7 isoform 2
NM_001370997.1 NP_001357926.1 rho GTPase-activating protein 7 isoform 1

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables GTPase activator activity IDA
IDA: Inferred from direct assay
7835339 RGD
enables phospholipase C activator activity IDA
IDA: Inferred from direct assay
7835339 RGD
enables phospholipase binding IPI
IPI: Inferred from physical interaction
18157946 RGD
enables vinculin binding IPI
IPI: Inferred from physical interaction
15506980 RGD
Biological Process GO Annotation Evidence References Source
involved in cellular response to insulin stimulus IEP
IEP: Inferred from expression pattern
16338927 RGD
Cellular Component GO Annotation Evidence References Source
located in actin filament IDA
IDA: Inferred from direct assay
15506980 RGD
located in focal adhesion IDA
IDA: Inferred from direct assay
15506980 RGD
located in stress fiber IDA
IDA: Inferred from direct assay
15506980 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

rho GTPase-activating protein 7

  • START domain-containing protein 12

  • deleted in liver cancer 1 protein homolog

  • dlc-1

  • p122-RhoGAP

  • rho-type GTPase-activating protein 7

  • stAR-related lipid transfer protein 12

  • stARD12

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (5)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS03793 DLC1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS03795 DLEC1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS04088 DYNLL1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS19126 Dlc1 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS25616 Dlc1 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Dlc1 NCBI NCBI:10395