DLC1 - DLC1 Rho GTPase activating protein Gene

Also Known as HP; ARHGAP7; STARD12; p122-RhoGAP

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 10395

About DLC1

Cytogenetic location: 8p22 Genomic coordinates (GRCh38): 8:13,083,361-13,604,620 (from NCBI)

This gene has 18 transcripts (splice variants), 205 orthologues, 2 paralogues and is associated with 1 phenotype. Broad expression in lung (RPKM 21.4), fat (RPKM 12.0) and 21 other tissues.

Summary

This gene encodes a GTPase-activating protein (GAP) that is a member of the rhoGAP family of proteins which play a role in the regulation of small GTP-binding proteins. GAP family proteins participate in signaling pathways that regulate cell processes involved in cytoskeletal changes. This gene functions as a tumor suppressor gene in a number of common cancers, including prostate, lung, colorectal, and breast cancers. Multiple transcript variants due to alternative promoters and alternative splicing have been found for this gene.[provided by RefSeq, Apr 2010]

DLC1 Products (26)

mRNA Protein Name
NM_001164271.2 NP_001157743.1 rho GTPase-activating protein 7 isoform 4
NM_001316668.2 NP_001303597.1 rho GTPase-activating protein 7 isoform 5
NM_001348081.2 NP_001335010.1 rho GTPase-activating protein 7 isoform 1
NM_001348082.2 NP_001335011.1 rho GTPase-activating protein 7 isoform 4
NM_001348083.1 NP_001335012.1 rho GTPase-activating protein 7 isoform 4
NM_001348084.2 NP_001335013.1 rho GTPase-activating protein 7 isoform 4
NM_001413124.1 NP_001400053.1 rho GTPase-activating protein 7 isoform 1
NM_001413125.1 NP_001400054.1 rho GTPase-activating protein 7 isoform 14
NM_001413126.1 NP_001400055.1 rho GTPase-activating protein 7 isoform 4
NM_001413127.1 NP_001400056.1 rho GTPase-activating protein 7 isoform 4
NM_001413128.1 NP_001400057.1 rho GTPase-activating protein 7 isoform 4
NM_001413129.1 NP_001400058.1 rho GTPase-activating protein 7 isoform 6
NM_001413130.1 NP_001400059.1 rho GTPase-activating protein 7 isoform 7
NM_001413131.1 NP_001400060.1 rho GTPase-activating protein 7 isoform 8
NM_001413132.1 NP_001400061.1 rho GTPase-activating protein 7 isoform 9
NM_001413133.1 NP_001400062.1 rho GTPase-activating protein 7 isoform 4
NM_001413134.1 NP_001400063.1 rho GTPase-activating protein 7 isoform 10
NM_001413135.1 NP_001400064.1 rho GTPase-activating protein 7 isoform 11
NM_001413136.1 NP_001400065.1 rho GTPase-activating protein 7 isoform 12
NM_001413137.1 NP_001400066.1 rho GTPase-activating protein 7 isoform 8
NM_001413138.1 NP_001400067.1 rho GTPase-activating protein 7 isoform 4
NM_001413139.1 NP_001400068.1 rho GTPase-activating protein 7 isoform 15
NM_001413140.1 NP_001400069.1 rho GTPase-activating protein 7 isoform 16
NM_006094.5 NP_006085.2 rho GTPase-activating protein 7 isoform 2
NM_024767.5 NP_079043.3 rho GTPase-activating protein 7 isoform 3
NM_182643.3 NP_872584.2 rho GTPase-activating protein 7 isoform 1

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
NOT enables GTPase activator activity IDA
IDA: Inferred from direct assay
17932950 GOA
enables GTPase activator activity IMP
IMP: Inferred from mutant phenotype
17888903 GOA
enables SH2 domain binding IPI
IPI: Inferred from physical interaction
17190795 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
16951145 GOA
Biological Process GO Annotation Evidence References Source
involved in activation of cysteine-type endopeptidase activity involved in apoptotic process IDA
IDA: Inferred from direct assay
17888903 GOA
involved in apoptotic process IDA
IDA: Inferred from direct assay
17292327 GOA
involved in negative regulation of Rho protein signal transduction IMP
IMP: Inferred from mutant phenotype
16951145 GOA
involved in negative regulation of cell migration IDA
IDA: Inferred from direct assay
17932950 GOA
involved in negative regulation of cell migration IMP
IMP: Inferred from mutant phenotype
17292327 GOA
involved in negative regulation of cell population proliferation IDA
IDA: Inferred from direct assay
12545165 GOA
involved in negative regulation of cell population proliferation IMP
IMP: Inferred from mutant phenotype
17292327 GOA
involved in negative regulation of focal adhesion assembly IDA
IDA: Inferred from direct assay
19158340 GOA
involved in negative regulation of stress fiber assembly IDA
IDA: Inferred from direct assay
17932950 GOA
involved in positive regulation of execution phase of apoptosis IDA
IDA: Inferred from direct assay
17888903 GOA
involved in regulation of actin cytoskeleton organization IMP
IMP: Inferred from mutant phenotype
17292327 GOA
involved in regulation of cell shape IMP
IMP: Inferred from mutant phenotype
17292327 GOA
Cellular Component GO Annotation Evidence References Source
located in caveola IDA
IDA: Inferred from direct assay
16951145 GOA
located in cortical actin cytoskeleton IDA
IDA: Inferred from direct assay
19158340 GOA
located in cytoplasm IDA
IDA: Inferred from direct assay
16951145 GOA
located in cytosol IDA
IDA: Inferred from direct assay
19158340 GOA
located in focal adhesion IDA
IDA: Inferred from direct assay
16951145 GOA
located in nucleus IDA
IDA: Inferred from direct assay
17888903 GOA
located in ruffle membrane IDA
IDA: Inferred from direct assay
19158340 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

DLC1 Protein Structure

SAM_2

SAM_2: SAM domain (Sterile alpha motif) (454 - 513)

RhoGAP

RhoGAP: RhoGAP domain (1092 - 1236)

START

START: START domain (1326 - 1522)

  • 0
  • 300
  • 600
  • 900
  • 1200
  • 1528 a.a.
Protein Preferred Names Protein Names

rho GTPase-activating protein 7

  • Rho-GTPase-activating protein 7

DLC1 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
DLC1 Q96QB1 RASA1 Homo sapiens P20936
Y2H
19151751
Intra
DLC1 Q96QB1 RASA1 Homo sapiens P20936
Y2H Array
24412244
Intra
DLC1 Q96QB1 RASA1 Homo sapiens P20936
Anti Tag CoIP
19151751
Cross: Cross-species interaction Intra: Intraspecies interaction

DLC1 Antibodies

Cat. No. Product Name Application Reactivity
HY-P811195 DLC1 Antibody WB, IHC-P, ICC/IF Human, Mouse, Rat

Related Diseases

Diseases Alias
Colorectal Cancer

  • Colon Cancer

  • Colorectal Carcinoma

  • Colon Carcinoma

  • Colorectal Cancer, Susceptibility To

  • Carcinoma Of Colon

  • CRC

  • Colorectal Cancer With Chromosomal Instability, Somatic

  • Colon Cancer, Somatic

  • Colon Cancer, Susceptibility To

  • Colonic Neoplasms

  • Colorectal Neoplasms

  • Colorectal Cancer, Somatic

  • Colon Cancer, Advanced, Somatic

  • Colonic Carcinoma

  • Colorectal Carcinomas

  • Colon Cancers

  • Colorectal Cancers

  • Cancer, Colorectal, Somatic

  • Cancer, Colon

  • Cancer, Colorectal, Susceptibility To

  • Colorectal Neoplasm

  • Colonic Neoplasm

  • Malignant Tumor Of Colon
Neural Tube Defects

  • Spina Bifida

  • Neural Tube Defect

  • NTD

  • Neural Tube Defects, Susceptibility To

  • Spinal Dysraphism

  • Spina Bifida, Susceptibility To

  • Rachischisis

  • Cleft Spine

  • Open Spine

  • Hydrocele Spinalis

  • Neural Tube Defect Nos

  • Sb - [Spina Bifida]

  • Spinal Hernia Nos

  • Spinal Fissure Nos
Hepatocellular Carcinoma

  • Liver Cancer

  • Primary Liver Cancer

  • HCC

  • Hepatoma

  • Malignant Neoplasm Of Liver

  • Liver Neoplasms

  • Cancer, Hepatocellular

  • Liver Cell Carcinoma

  • Lcc

  • Hepatoblastoma, Somatic

  • Hepatic Cancer

  • Primary Malignant Neoplasm Of Liver

  • Rare Tumor Of Liver And Intrahepatic Biliary Tract

  • Hepatocellular Carcinoma, Somatic

  • Hepatocellular Carcinoma, Childhood Type, Somatic

  • Hepatocellular Cancer, Somatic

  • Ca Liver - Primary

  • Hepatic Neoplasm

  • Malignant Hepato-Biliary Neoplasm

  • Malignant Neoplasm Of Liver, Not Specified As Primary Or Secondary

  • Malignant Neoplasm Of Liver, Primary

  • Malignant Tumor Of Liver

  • Neoplasm Of Liver

  • Non-Resectable Primary Hepatic Malignant Neoplasm

  • Resectable Malignant Neoplasm Of Liver

  • Resectable Malignant Neoplasm Of The Liver

  • Primary Liver Carcinoma

  • Primary Malignant Liver Neoplasm

  • Primary Cancer Of Liver

  • Primary Tumor Of The Liver

  • Rare Tumor Of Liver And Ibt

  • Hepatocellular Cancer

  • Neoplasm Of The Liver

  • Carcinoma, Hepatocellular

  • Hepatomas

  • Liver Neoplasm

  • Liver Carcinoma

  • Liver And Intrahepatic Biliary Tract Carcinoma

  • Malignant Hepatobiliary Neoplasm

  • Adult Primary Hepatocellular Carcinoma

  • Hepatoblastoma

  • Carcinoma Of Liver

  • Malignant Liver Tumour

  • Malignant Hepatic Tumour
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (5)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS03793 DLC1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS03795 DLEC1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS04088 DYNLL1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS19126 Dlc1 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS25616 Dlc1 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Rattus norvegicus DLC1 RGD RGD:68416
Macaca mulatta DLC1 VGNC VGNC:83993
Mus musculus DLC1 MGD MGI:1354949
Felis catus DLC1 VGNC VGNC:61509
Canis familiaris DLC1 VGNC VGNC:39975
Bos taurus DLC1 VGNC VGNC:28084
Others DLC1 NCBI