Grk5 - G protein-coupled receptor kinase 5 Gene

Also Known as Gprk5

Species: Rattus norvegicus

Gene Type: protein coding
Gene ID: 59075

Summary

Predicted to enable beta-adrenergic receptor kinase activity and protein serine/threonine kinase activity. Involved in negative regulation of G protein-coupled receptor signaling pathway; oligodendrocyte differentiation; and response to alkaloid. Predicted to be located in cytosol; nucleus; and plasma membrane. Predicted to be active in cytoplasm. Biomarker of Parkinson's disease and hypertension. Orthologous to human GRK5 (G protein-coupled receptor kinase 5). [provided by Alliance of Genome Resources, Apr 2022]

Grk5 Products (1)

mRNA Protein Name
NM_030829.2 NP_110456.2 G protein-coupled receptor kinase 5

Gene Ontology

  • Biological Process
Biological Process GO Annotation Evidence References Source
involved in desensitization of G protein-coupled receptor signaling pathway IMP
IMP: Inferred from mutant phenotype
8626574 RGD
involved in negative regulation of adenylate cyclase-activating G protein-coupled receptor signaling pathway IMP
IMP: Inferred from mutant phenotype
30075183 RGD
involved in oligodendrocyte differentiation IEP
IEP: Inferred from expression pattern
24613411 RGD
involved in regulation of G protein-coupled receptor signaling pathway IMP
IMP: Inferred from mutant phenotype
8626574 RGD
involved in response to cocaine IEP
IEP: Inferred from expression pattern
25213649 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

G protein-coupled receptor kinase 5

  • g protein-coupled receptor kinase GRK5

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-179707 GRL-03022 Inhibitor / Unkown
HY-120168 CCG 258001 Inhibitor / Unkown
HY-180583 GRK5-IN-5 Inhibitor / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Grk5 NCBI NCBI:2869