RASGRF2 - Ras protein specific guanine nucleotide releasing factor 2 Gene

Also Known as GRF2; RAS-GRF2

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 5924

About RASGRF2

Cytogenetic location: 5q14.1 Genomic coordinates (GRCh38): 5:80,960,363-81,230,162 (from NCBI)

This gene has 6 transcripts (splice variants), 275 orthologues and 24 paralogues. Broad expression in brain (RPKM 9.6), ovary (RPKM 7.2) and 18 other tissues.

Summary

Ras GTPases cycle between an inactive GDP-bound state and an active GTP-bound state. This gene encodes a calcium-regulated nucleotide exchange factor activating both Ras and RAS-related protein, RAC1, through the exchange of bound GDP for GTP, thereby, coordinating the signaling of distinct mitogen-activated protein kinase pathways. [provided by RefSeq, Oct 2011]

RASGRF2 Products (1)

mRNA Protein Name
NM_006909.3 NP_008840.1 ras-specific guanine nucleotide-releasing factor 2

Gene Ontology

  • Molecular Function
  • Biological Process
Molecular Function GO Annotation Evidence References Source
enables guanyl-nucleotide exchange factor activity IMP
IMP: Inferred from mutant phenotype
27856453 GOA
Biological Process GO Annotation Evidence References Source
involved in response to endoplasmic reticulum stress IMP
IMP: Inferred from mutant phenotype
27856453 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

RASGRF2 Protein Structure

PH

PH: PH domain (25 - 132)

RhoGEF

RhoGEF: RhoGEF domain (249 - 426)

RasGEF_N

RasGEF_N: RasGEF N-terminal motif (638 - 749)

RasGEF

RasGEF: RasGEF domain (1000 - 1184)

  • 0
  • 200
  • 400
  • 600
  • 800
  • 1000
  • 1237 a.a.
Protein Preferred Names Protein Names

ras-specific guanine nucleotide-releasing factor 2

  • ras guanine nucleotide exchange factor 2

Related Diseases

Diseases Alias
Schizophrenia 12

  • Sczd12

  • Schizophrenia Susceptibility Locus, Chromosome 1p-Related
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS11692 RASGRF2 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Canis familiaris RASGRF2 VGNC VGNC:45371
Rattus norvegicus RASGRF2 RGD RGD:69413
Macaca mulatta RASGRF2 VGNC VGNC:84486
Felis catus RASGRF2 VGNC VGNC:69250
Bos taurus RASGRF2 VGNC VGNC:33746
Mus musculus RASGRF2 MGD MGI:109137
Others RASGRF2 NCBI