Nucb2 - nucleobindin 2 Gene

Also Known as p54; Nefa

Species: Rattus norvegicus

Gene Type: protein coding
Gene ID: 59295

Summary

Enables G-protein alpha-subunit binding activity; guanyl-nucleotide exchange factor activity; and tumor necrosis factor receptor binding activity. Involved in several processes, including negative regulation of cell communication; positive regulation of testosterone secretion; and response to melanocyte-stimulating hormone. Located in Golgi medial cisterna and extracellular space. Biomarker of obesity and type 2 diabetes mellitus. Orthologous to human NUCB2 (nucleobindin 2). [provided by Alliance of Genome Resources, Apr 2022]

Nucb2 Products (1)

mRNA Protein Name
NM_021663.2 NP_067695.1 nucleobindin-2 precursor

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables G-protein alpha-subunit binding IDA
IDA: Inferred from direct assay
21653697 RGD
enables guanyl-nucleotide exchange factor activity IDA
IDA: Inferred from direct assay
21653697 RGD
enables tumor necrosis factor receptor binding IPI
IPI: Inferred from physical interaction
20649583 RGD
Biological Process GO Annotation Evidence References Source
involved in insulin metabolic process IDA
IDA: Inferred from direct assay
21828181 RGD
involved in negative regulation of appetite IMP
IMP: Inferred from mutant phenotype
17036007 RGD
involved in negative regulation of cAMP/PKA signal transduction IDA
IDA: Inferred from direct assay
22486620 RGD
involved in negative regulation of fat cell differentiation IDA
IDA: Inferred from direct assay
22486620 RGD
involved in negative regulation of glucagon secretion IDA
IDA: Inferred from direct assay
21828181 RGD
involved in negative regulation of insulin receptor signaling pathway IDA
IDA: Inferred from direct assay
22486620 RGD
involved in positive regulation of fatty acid oxidation IDA
IDA: Inferred from direct assay
21828181 RGD
involved in positive regulation of testosterone secretion IDA
IDA: Inferred from direct assay
22334726 RGD
involved in response to glucose IEP
IEP: Inferred from expression pattern
20032201 RGD
involved in response to human chorionic gonadotropin IEP
IEP: Inferred from expression pattern
22334726 RGD
involved in response to melanocyte-stimulating hormone IEP
IEP: Inferred from expression pattern
17036007 RGD
involved in response to starvation IEP
IEP: Inferred from expression pattern
22334726 RGD
involved in small GTPase-mediated signal transduction IDA
IDA: Inferred from direct assay
21653697 RGD
Cellular Component GO Annotation Evidence References Source
located in Golgi medial cisterna IDA
IDA: Inferred from direct assay
11893086 RGD
located in extracellular space IDA
IDA: Inferred from direct assay
17036007 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

nucleobindin-2

  • DNA-binding protein NEFA

  • nesfatin-1

  • prepronefastin

  • prepronesfatin

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS09655 NUCB2 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS18672 Nucb2 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS25158 Nucb2 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Nucb2 NCBI NCBI:4925