NUCB2 - nucleobindin 2 Gene

Homo sapiens

Also known as NEFA; HEL-S-109

Gene ID: 4925 | Gene type: protein coding

About NUCB2

Cytogenetic location: 11p15.1 Genomic coordinates (GRCh38): 11:17,276,739-17,349,980 (from NCBI)

This gene has 19 transcripts (splice variants), 279 orthologues and 1 paralogue. Broad expression in bone marrow (RPKM 51.4), salivary gland (RPKM 41.2) and 24 other tissues.

Summary

This gene encodes a protein with a suggested role in calcium level maintenance, eating regulation in the hypothalamus, and release of tumor necrosis factor from vascular endothelial cells. This protein binds calcium and has EF-folding domains. [provided by RefSeq, Oct 2011]

NUCB2 Products(14)

mRNA	Protein	Name
NM_001330227.3	NP_001317156.1	nucleobindin-2 isoform 2 preproprotein
NM_001352661.2	NP_001339590.1	nucleobindin-2 isoform 3 preproprotein
NM_001352662.2	NP_001339591.1	nucleobindin-2 isoform 4 preproprotein
NM_001352663.2	NP_001339592.1	nucleobindin-2 isoform 3 preproprotein
NM_001352664.2	NP_001339593.1	nucleobindin-2 isoform 1 preproprotein
NM_001352665.2	NP_001339594.1	nucleobindin-2 isoform 2 preproprotein
NM_001352666.2	NP_001339595.1	nucleobindin-2 isoform 2 preproprotein
NM_001352667.2	NP_001339596.1	nucleobindin-2 isoform 2 preproprotein
NM_001352668.2	NP_001339597.1	nucleobindin-2 isoform 1 preproprotein
NM_001352669.2	NP_001339598.1	nucleobindin-2 isoform 1 preproprotein
NM_001352670.2	NP_001339599.1	nucleobindin-2 isoform 1 preproprotein
NM_001352671.2	NP_001339600.1	nucleobindin-2 isoform 2 preproprotein
NM_001352672.2	NP_001339601.1	nucleobindin-2 isoform 1 preproprotein
NM_005013.4	NP_005004.1	nucleobindin-2 isoform 1 preproprotein

NUCB2 Protein Structure

EF-hand_7

0
100
200
300
420 a.a.

Protein Preferred Names

Protein Names

nucleobindin-2

DNA-binding protein NEFA

Recombinant NUCB2 Proteins

Cat. No.	Product Name	Accession	Purity
HY-P71177	Nucleobindin-2 Protein, Human	P80303 (V25-L106)	≥95%

Related Diseases

Diseases

Alias

Gastric Cancer

Stomach Cancer	Gastric Carcinoma
Stomach Carcinoma	Gastric Cancer, Somatic
Gastric Neoplasm	Carcinoma Of Stomach
Stomach Neoplasms	Malignant Neoplasm Of Stomach
Gastric Cancer Risk After H. Pylori Infection	Cancer Of The Stomach
Adult Stomach Cancer	Adult Stomach Carcinoma
GASC	Gastric Cancer Intestinal
Gastric Cancers	Gastric Carcinomas
Cancer, Gastric	Stomach Neoplasm
Malignant Neoplasm Of Body Of Stomach	Malignant Tumor Of Lesser Curve Of Stomach
Gastrocarcinoma Of Unspecified Site	Leather Bottle Stomach
Carcinoma Of Fundus Of Stomach	Cancer Of Fundus Of Stomach
Primary Malignant Neoplasm Of Body Of Stomach	Cancer Of Body Of Stomach
Primary Malignant Neoplasm Of Pyloric Antrum	Pyloric Antrum Cancer
Malignant Tumour Of Stomach

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS09655	NUCB2 Human Pre-designed siRNA Set A		/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Rattus norvegicus	NUCB2	RGD	RGD:620888
Bos taurus	NUCB2	VGNC	VGNC:32319
Mus musculus	NUCB2	MGD	MGI:1858179
Felis catus	NUCB2	VGNC	VGNC:68587
Macaca mulatta	NUCB2	VGNC	VGNC:75549
Canis familiaris	NUCB2	VGNC	VGNC:44020
Others	NUCB2	NCBI

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