NUCB2 - nucleobindin 2 Gene

Also Known as NEFA; HEL-S-109

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 4925

About NUCB2

Cytogenetic location: 11p15.1 Genomic coordinates (GRCh38): 11:17,276,739-17,349,980 (from NCBI)

This gene has 19 transcripts (splice variants), 279 orthologues and 1 paralogue. Broad expression in bone marrow (RPKM 51.4), salivary gland (RPKM 41.2) and 24 other tissues.

Summary

This gene encodes a protein with a suggested role in calcium level maintenance, eating regulation in the hypothalamus, and release of tumor necrosis factor from vascular endothelial cells. This protein binds calcium and has EF-folding domains. [provided by RefSeq, Oct 2011]

NUCB2 Products (14)

mRNA Protein Name
NM_001330227.3 NP_001317156.1 nucleobindin-2 isoform 2 preproprotein
NM_001352661.2 NP_001339590.1 nucleobindin-2 isoform 3 preproprotein
NM_001352662.2 NP_001339591.1 nucleobindin-2 isoform 4 preproprotein
NM_001352663.2 NP_001339592.1 nucleobindin-2 isoform 3 preproprotein
NM_001352664.2 NP_001339593.1 nucleobindin-2 isoform 1 preproprotein
NM_001352665.2 NP_001339594.1 nucleobindin-2 isoform 2 preproprotein
NM_001352666.2 NP_001339595.1 nucleobindin-2 isoform 2 preproprotein
NM_001352667.2 NP_001339596.1 nucleobindin-2 isoform 2 preproprotein
NM_001352668.2 NP_001339597.1 nucleobindin-2 isoform 1 preproprotein
NM_001352669.2 NP_001339598.1 nucleobindin-2 isoform 1 preproprotein
NM_001352670.2 NP_001339599.1 nucleobindin-2 isoform 1 preproprotein
NM_001352671.2 NP_001339600.1 nucleobindin-2 isoform 2 preproprotein
NM_001352672.2 NP_001339601.1 nucleobindin-2 isoform 1 preproprotein
NM_005013.4 NP_005004.1 nucleobindin-2 isoform 1 preproprotein

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
21988832 GOA
Biological Process GO Annotation Evidence References Source
involved in sequestering of metal ion EXP
EXP: Inferred from Experiment
32184136 GOA
Cellular Component GO Annotation Evidence References Source
located in endoplasmic reticulum-Golgi intermediate compartment IDA
IDA: Inferred from direct assay
15308636 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

NUCB2 Protein Structure

EF-hand_7

EF-hand_7: EF-hand domain pair (248 - 321)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 420 a.a.
Protein Preferred Names Protein Names

nucleobindin-2

  • DNA-binding protein NEFA

NUCB2 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
NUCB2 P80303 GADD45A Homo sapiens P24522
Y2H
21988832
Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant NUCB2 Proteins

Cat. No. Product Name Accession Purity
HY-P71177 Nucleobindin-2 Protein, Human P80303-1 (V25-L106) ≥ 95%, as determined by reducing SDS-PAGE.

Related Diseases

Diseases Alias
Gastric Cancer

  • Stomach Cancer

  • Gastric Carcinoma

  • Stomach Carcinoma

  • Gastric Cancer, Somatic

  • Gastric Neoplasm

  • Carcinoma Of Stomach

  • Stomach Neoplasms

  • Malignant Neoplasm Of Stomach

  • Gastric Cancer Risk After H. Pylori Infection

  • Cancer Of The Stomach

  • Adult Stomach Cancer

  • Adult Stomach Carcinoma

  • GASC

  • Gastric Cancer Intestinal

  • Gastric Cancers

  • Gastric Carcinomas

  • Cancer, Gastric

  • Stomach Neoplasm

  • Malignant Neoplasm Of Body Of Stomach

  • Malignant Tumor Of Lesser Curve Of Stomach

  • Gastrocarcinoma Of Unspecified Site

  • Leather Bottle Stomach

  • Carcinoma Of Fundus Of Stomach

  • Cancer Of Fundus Of Stomach

  • Primary Malignant Neoplasm Of Body Of Stomach

  • Cancer Of Body Of Stomach

  • Primary Malignant Neoplasm Of Pyloric Antrum

  • Pyloric Antrum Cancer

  • Malignant Tumour Of Stomach
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS09655 NUCB2 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS18672 Nucb2 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS25158 Nucb2 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Rattus norvegicus NUCB2 RGD RGD:620888
Bos taurus NUCB2 VGNC VGNC:32319
Mus musculus NUCB2 MGD MGI:1858179
Felis catus NUCB2 VGNC VGNC:68587
Macaca mulatta NUCB2 VGNC VGNC:75549
Canis familiaris NUCB2 VGNC VGNC:44020
Others NUCB2 NCBI