REG1A - regenerating family member 1 alpha Gene

Also Known as P19; PSP; PTP; REG; ICRF; PSPS; PSPS1

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 5967

About REG1A

Cytogenetic location: 2p12 Genomic coordinates (GRCh38): 2:79,120,488-79,123,409 (from NCBI)

This gene has 4 transcripts (splice variants), 777 orthologues and 5 paralogues. Biased expression in pancreas (RPKM 5037.4), duodenum (RPKM 2788.3) and 2 other tissues.

Summary

This gene is a type I subclass member of the Reg gene family. The Reg gene family is a multigene family grouped into four subclasses, types I, II, III and IV, based on the primary structures of the encoded proteins. This gene encodes a protein that is secreted by the exocrine pancreas. It is associated with islet cell regeneration and diabetogenesis and may be involved in pancreatic lithogenesis. Reg family members REG1B, REGL, PAP and this gene are tandemly clustered on chromosome 2p12 and may have arisen from the same ancestral gene by gene duplication. [provided by RefSeq, Jul 2008]

REG1A Products (1)

mRNA Protein Name
NM_002909.5 NP_002900.2 lithostathine-1-alpha precursor

Gene Ontology

  • Molecular Function
Molecular Function GO Annotation Evidence References Source
enables growth factor activity IDA
IDA: Inferred from direct assay
10526060 GOA
enables molecular function inhibitor activity IDA
IDA: Inferred from direct assay
1397886 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
28514442 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

REG1A Protein Structure

Lectin_C

Lectin_C: Lectin C-type domain (54 - 163)

  • 0
  • 100
  • 166 a.a.
Protein Preferred Names Protein Names

lithostathine-1-alpha

  • REG-1-alpha

REG1A Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
REG1A P05451 REG1B Homo sapiens P48304
Anti Tag CoIP
33961781
Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant REG1A Proteins

Cat. No. Product Name Accession Purity
HY-P71078 REG-1 alpha/REG1A Protein, Human (HEK293, His) P05451 (Q23-N166) ≥ 95%, as determined by reducing SDS-PAGE.

REG1A Antibodies

Cat. No. Product Name Application Reactivity
HY-P85350 REG1 alpha Antibody (YA5042) IHC-P, ICC/IF, ELISA Human
HY-P85350A REG1 alpha Antibody (YA5042)(PBS only) IHC-P, ICC/IF, ELISA Human

Related Diseases

Diseases Alias
Acinar Cell Carcinoma

  • Acinic Cell Carcinoma

  • Acinic Cell Tumor

  • Carcinoma Acinar Cell

  • Carcinoma, Acinar Cell

  • Acinar Cell Tumor
Pancreatitis

  • Mumps Pancreatitis
Pancreas Disease

  • Abnormality Of The Pancreas

  • Pancreatic Diseases
Pancreatitis, Hereditary

  • Hereditary Pancreatitis

  • Chronic Pancreatitis

  • Hereditary Chronic Pancreatitis

  • Hp

  • Pancreatitis, Chronic, Susceptibility To

  • PCTT

  • Hpc

  • Pancreatitis, Chronic

  • Pancreatitis, Chronic, Protection Against

  • Autosomal Dominant Hereditary Pancreatitis

  • Familial Pancreatitis

  • Cp

  • Pancreatitis Hereditary
Cystic Echinococcosis

  • Echinococcus Granulosus Infection

  • Echinococcus Granulosus Infection Of Lung

  • Echinococcus Granulosus

  • Echinococcus Granulosus Infection Of Thyroid

  • Echinococcus Granulosus Infectious Disease

  • Echinococcus Granulosus Infectious Disease Of Liver

  • Echinococcus Granulosus Infectious Disease Of Thyroid

  • Liver Echinococcus Granulosus

  • Lung Echinococcus Granulosus

  • Thyroid Echinococcus Granulosus

  • Unilocular Echinococcosis

  • Unilocular Hydatid Disease

  • Hydatid Disease

  • Hydatidosis

  • Echinococcosis
Bone Angioendothelial Sarcoma

  • Osseous Hemangiosarcoma

  • Bone Angiosarcoma
Pancreatic Cancer

  • Pancreatic Carcinoma

  • Carcinoma Of Pancreas

  • Familial Pancreatic Carcinoma

  • Pancreatic Neoplasm

  • Pancreatic Carcinoma, Familial

  • Malignant Neoplasm Of Pancreas

  • Pancreatic Acinar Carcinoma

  • Pancreatic Tumor

  • Familial Pancreatic Cancer

  • Neoplasm Of The Pancreas

  • Cancer Of The Pancreas

  • Pancreatic Carcinoma, Somatic

  • Pancreatic Cancer, Somatic

  • Ca Body Of Pancreas

  • Ca Head Of Pancreas

  • Ca Tail Of Pancreas

  • Malignant Neoplasm Of Body Of Pancreas

  • Malignant Neoplasm Of Head Of Pancreas

  • Malignant Neoplasm Of Tail Of Pancreas

  • Pancreas Neoplasm

  • Exocrine Cancer

  • Exocrine Pancreas Carcinoma

  • Hereditary Pancreatic Cancer

  • Hereditary Pancreatic Carcinoma

  • PNCA

  • Pancreatic Cancer, Susceptibility To

  • Carcinoma Of Head Of Pancreas

  • Pancreatic Neoplasms

  • Pancreatic Tumors

  • Cancer, Pancreatic

  • Cancer Of Pancreas

  • Mixed Islet Cell With Exocrine Carcinoma Of Unspecified Site
Diabetes Mellitus

  • Diabetes
Alzheimer Disease, Familial, 1

  • Alzheimer Disease

  • Alzheimer'S Disease

  • Presenile And Senile Dementia

  • AD1

  • Alzheimer Disease, Susceptibility To

  • Alzheimer Disease, Late-Onset, Susceptibility To

  • Alzheimer Disease 1, Familial

  • AD

  • Familial Alzheimer Disease

  • Alzheimer Disease, Late-Onset

  • Alzheimers Dementia

  • Alzheimer Dementia

  • Alzheimer Sclerosis

  • Alzheimer Syndrome

  • Alzheimer-Type Dementia

  • Dat

  • Primary Senile Degenerative Dementia

  • Sdat

  • Alzheimer Disease 1

  • Autosomal Dominant Alzheimer Disease

  • Early-Onset Alzheimer Disease With Cerebral Amyloid Angiopathy

  • Late Onset Alzheimer Disease

  • Alzheimers Disease

  • Alzheimer Disease, Early-Onset, With Cerebral Amyloid Angiopathy

  • Late-Onset Alzheimers Disease

  • Alzheimer'S Disease Pathway Kegg

  • Dementia Due To Alzheimer'S Disease

  • Alzheimer Disease Type 1

  • Alzheimers
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (2)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS11818 REG1A Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS24389 Reg1a Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Rattus norvegicus REG1A RGD RGD:3552
Others REG1A NCBI