REG1A - regenerating family member 1 alpha Gene

Homo sapiens

Also known as P19; PSP; PTP; REG; ICRF; PSPS; PSPS1

Gene ID: 5967 | Gene type: protein coding

About REG1A

Cytogenetic location: 2p12 Genomic coordinates (GRCh38): 2:79,120,488-79,123,409 (from NCBI)

This gene has 4 transcripts (splice variants), 777 orthologues and 5 paralogues. Biased expression in pancreas (RPKM 5037.4), duodenum (RPKM 2788.3) and 2 other tissues.

Summary

This gene is a type I subclass member of the Reg gene family. The Reg gene family is a multigene family grouped into four subclasses, types I, II, III and IV, based on the primary structures of the encoded proteins. This gene encodes a protein that is secreted by the exocrine pancreas. It is associated with islet cell regeneration and diabetogenesis and may be involved in pancreatic lithogenesis. Reg family members REG1B, REGL, PAP and this gene are tandemly clustered on chromosome 2p12 and may have arisen from the same ancestral gene by gene duplication. [provided by RefSeq, Jul 2008]

REG1A Products(1)

mRNA	Protein	Name
NM_002909.5	NP_002900.2	lithostathine-1-alpha precursor

REG1A Protein Structure

Lectin_C

0
100
166 a.a.

Protein Preferred Names

Protein Names

lithostathine-1-alpha

REG-1-alpha

Recombinant REG1A Proteins

Cat. No.	Product Name	Accession	Purity
HY-P71078	REG-1 alpha/REG1A Protein, Human (HEK293, His)	P05451 (Q23-N166)	≥95%

Related Diseases

Diseases

Alias

Acinar Cell Carcinoma

Acinic Cell Carcinoma	Acinic Cell Tumor
Carcinoma Acinar Cell	Carcinoma, Acinar Cell
Acinar Cell Tumor

Pancreatitis

Mumps Pancreatitis

Pancreas Disease

Abnormality Of The Pancreas

Pancreatic Diseases

Pancreatitis, Hereditary

Hereditary Pancreatitis	Chronic Pancreatitis
Hereditary Chronic Pancreatitis	Hp
Pancreatitis, Chronic, Susceptibility To	PCTT
Hpc	Pancreatitis, Chronic
Pancreatitis, Chronic, Protection Against	Autosomal Dominant Hereditary Pancreatitis
Familial Pancreatitis	Cp
Pancreatitis Hereditary

Cystic Echinococcosis

Echinococcus Granulosus Infection	Echinococcus Granulosus Infection Of Lung
Echinococcus Granulosus	Echinococcus Granulosus Infection Of Thyroid
Echinococcus Granulosus Infectious Disease	Echinococcus Granulosus Infectious Disease Of Liver
Echinococcus Granulosus Infectious Disease Of Thyroid	Liver Echinococcus Granulosus
Lung Echinococcus Granulosus	Thyroid Echinococcus Granulosus
Unilocular Echinococcosis	Unilocular Hydatid Disease
Hydatid Disease	Hydatidosis
Echinococcosis

Bone Angioendothelial Sarcoma

Osseous Hemangiosarcoma

Bone Angiosarcoma

Pancreatic Cancer

Pancreatic Carcinoma	Carcinoma Of Pancreas
Familial Pancreatic Carcinoma	Pancreatic Neoplasm
Pancreatic Carcinoma, Familial	Malignant Neoplasm Of Pancreas
Pancreatic Acinar Carcinoma	Pancreatic Tumor
Familial Pancreatic Cancer	Neoplasm Of The Pancreas
Cancer Of The Pancreas	Pancreatic Carcinoma, Somatic
Pancreatic Cancer, Somatic	Ca Body Of Pancreas
Ca Head Of Pancreas	Ca Tail Of Pancreas
Malignant Neoplasm Of Body Of Pancreas	Malignant Neoplasm Of Head Of Pancreas
Malignant Neoplasm Of Tail Of Pancreas	Pancreas Neoplasm
Exocrine Cancer	Exocrine Pancreas Carcinoma
Hereditary Pancreatic Cancer	Hereditary Pancreatic Carcinoma
PNCA	Pancreatic Cancer, Susceptibility To
Carcinoma Of Head Of Pancreas	Pancreatic Neoplasms
Pancreatic Tumors	Cancer, Pancreatic
Cancer Of Pancreas	Mixed Islet Cell With Exocrine Carcinoma Of Unspecified Site

Diabetes Mellitus

Diabetes

Alzheimer Disease, Familial, 1

Alzheimer Disease	Alzheimer'S Disease
Presenile And Senile Dementia	AD1
Alzheimer Disease, Susceptibility To	Alzheimer Disease, Late-Onset, Susceptibility To
Alzheimer Disease 1, Familial	AD
Familial Alzheimer Disease	Alzheimer Disease, Late-Onset
Alzheimers Dementia	Alzheimer Dementia
Alzheimer Sclerosis	Alzheimer Syndrome
Alzheimer-Type Dementia	Dat
Primary Senile Degenerative Dementia	Sdat
Alzheimer Disease 1	Autosomal Dominant Alzheimer Disease
Early-Onset Alzheimer Disease With Cerebral Amyloid Angiopathy	Late Onset Alzheimer Disease
Alzheimers Disease	Alzheimer Disease, Early-Onset, With Cerebral Amyloid Angiopathy
Late-Onset Alzheimers Disease	Alzheimer'S Disease Pathway Kegg
Dementia Due To Alzheimer'S Disease	Alzheimer Disease Type 1
Alzheimers

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS11818	REG1A Human Pre-designed siRNA Set A		/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Rattus norvegicus	REG1A	RGD	RGD:3552
Macaca fascicularis	REG1A	NCBI
Others	REG1A	NCBI

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