Lmna - lamin A/C Gene

Species: Rattus norvegicus

Gene Type: protein coding
Gene ID: 60374

Summary

Enables protein Phosphatase 1 binding activity. Involved in several processes, including cellular senescence; negative regulation of adipose tissue development; and positive regulation of osteoblast differentiation. Located in nuclear matrix. Used to study transient cerebral ischemia. Biomarker of arteriosclerosis. Human ortholog(s) of this gene implicated in several diseases, including Charcot-Marie-Tooth disease type 2B1; intrinsic cardiomyopathy (multiple); lipodystrophy (multiple); muscular dystrophy (multiple); and type 2 diabetes mellitus (multiple). Orthologous to human LMNA (lamin A/C). [provided by Alliance of Genome Resources, Apr 2022]

Lmna Products (1)

mRNA Protein Name
NM_001002016.2 NP_001002016.2 prelamin-A/C
Protein Preferred Names Protein Names

prelamin-A/C

  • lamin A

  • lamin C2

Related Agents

  • Clinical Phase
  • Pre-clinical Phase

Clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Phase
HY-159834 Progerinin Inhibitor 99.74% Phase 2
Inhibitory Antibodies (1)
Cat. No. Product Name Effect
Purity Phase
HY-P99047 Simtuzumab Inhibitor ≥99.0% Phase 2

Pre-clinical Phase

Bioactive Molecules (6)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS07714 LMNA Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-144451 TRK-IN-12 Inhibitor / Unkown
HY-163366 TRK-IN-28 Inhibitor / Unkown
HY-180172 TRK-IN-33 / Unkown
HY-RS19910 Lmna Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS26411 Lmna Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Lmna NCBI NCBI:4000