Lif - LIF, interleukin 6 family cytokine Gene

Species: Rattus norvegicus

Gene Type: protein coding
Gene ID: 60584

Summary

Enables Leukemia Inhibitory Factor receptor binding activity. Involved in several processes, including negative regulation of angiogenesis; positive regulation of corticotropin secretion; and transdifferentiation. Located in extracellular space. Biomarker of brain ischemia and congestive heart failure. Orthologous to human LIF (LIF interleukin 6 family cytokine). [provided by Alliance of Genome Resources, Apr 2022]

Lif Products (1)

mRNA Protein Name
NM_022196.3 NP_071532.2 leukemia inhibitory factor precursor

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables leukemia inhibitory factor receptor binding IMP
IMP: Inferred from mutant phenotype
14638908 RGD
Biological Process GO Annotation Evidence References Source
involved in animal organ regeneration IEP
IEP: Inferred from expression pattern
16369772 RGD
involved in animal organ regeneration IMP
IMP: Inferred from mutant phenotype
14638908 RGD
involved in astrocyte differentiation IMP
IMP: Inferred from mutant phenotype
17328769 RGD
involved in negative regulation of angiogenesis IDA
IDA: Inferred from direct assay
16643897 RGD
involved in positive regulation of corticotropin secretion IDA
IDA: Inferred from direct assay
20160138 RGD
involved in positive regulation of neuron projection development IDA
IDA: Inferred from direct assay
18679704 RGD
involved in retina development in camera-type eye IDA
IDA: Inferred from direct assay
16643897 RGD
involved in transdifferentiation IMP
IMP: Inferred from mutant phenotype
20051627 RGD
Cellular Component GO Annotation Evidence References Source
located in extracellular space IDA
IDA: Inferred from direct assay
20160138 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

leukemia inhibitory factor

  • cholinergic neuronal differentiation factor

  • leukemia inhibitory factor (cholinergic differentiation factor)

Recombinant Lif Proteins

Cat. No. Product Name Accession Purity
HY-P78621 LIF Protein, Rat (HEK293, His) P17777 (S23-F202) ≥ 95%, as determined by reducing SDS-PAGE.

Related Agents

  • Clinical Phase
  • Pre-clinical Phase

Clinical Phase

Inhibitory Antibodies (1)
Cat. No. Product Name Effect
Purity Phase
HY-P990461 Anti-LIF Antibody (MSC-1) Inhibitor 98.51% Phase 1

Pre-clinical Phase

Bioactive Molecules (12)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-120142 EC359 Inducer 99.77% Unkown
HY-D0974 Sulforhodamine B sodium salt 99.43% Unkown
HY-100949 EC330 Inhibitor 99.90% Unkown
HY-D1603 BODIPY FL-EDA 97.86% Unkown
HY-103471 Y11 Activator 98.34% Unkown
HY-178477 LIFR/GPBAR1 modulator 1 / Unkown
HY-184832 P021 Inhibitor / Unkown
HY-RS07640 LIF Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-N16657 Fusaricidin B Inhibitor / Unkown
HY-RS16531 Lif Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS17192 Lifr Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS22962 Lif Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Lif NCBI NCBI:3976