RPS13 - ribosomal protein S13 Gene

Also Known as S13

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 6207

About RPS13

Cytogenetic location: 11p15.1 Genomic coordinates (GRCh38): 11:17,074,388-17,077,667 (from NCBI)

This gene has 10 transcripts (splice variants) and 211 orthologues. Ubiquitous expression in ovary (RPKM 892.5), lymph node (RPKM 558.5) and 25 other tissues.

Summary

Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes a ribosomal protein that is a component of the 40S subunit. The protein belongs to the S15P family of ribosomal proteins. It is located in the cytoplasm. The protein has been shown to bind to the 5.8S rRNA in rat. The gene product of the E. coli ortholog (ribosomal protein S15) functions at early steps in ribosome assembly. This gene is co-transcribed with two U14 small nucleolar RNA genes, which are located in its third and fifth introns. As is typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed through the genome. [provided by RefSeq, Jul 2008]

RPS13 Products (1)

mRNA Protein Name
NM_001017.3 NP_001008.1 40S ribosomal protein S13

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables mRNA 5'-UTR binding IDA
IDA: Inferred from direct assay
16213212 GOA
enables mRNA binding IDA
IDA: Inferred from direct assay
17881366 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
12054647 GOA
enables structural constituent of ribosome IDA
IDA: Inferred from direct assay
23636399 GOA
Biological Process GO Annotation Evidence References Source
involved in negative regulation of RNA splicing IDA
IDA: Inferred from direct assay
17881366 GOA
involved in ribosomal small subunit biogenesis IDA
IDA: Inferred from direct assay
34516797 GOA
Cellular Component GO Annotation Evidence References Source
located in cytosolic ribosome IDA
IDA: Inferred from direct assay
23636399 GOA
part of cytosolic small ribosomal subunit IDA
IDA: Inferred from direct assay
8706699 GOA
located in nucleolus IDA
IDA: Inferred from direct assay
17881366 GOA
located in nucleus IDA
IDA: Inferred from direct assay
17881366 GOA
is active in postsynaptic density EXP
EXP: Inferred from Experiment
21170055 GOA
is active in postsynaptic density IDA
IDA: Inferred from direct assay
21170055 GOA
part of small-subunit processome IDA
IDA: Inferred from direct assay
34516797 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

RPS13 Protein Structure

Ribosomal_S13_N

Ribosomal_S13_N: Ribosomal S13/S15 N-terminal domain (1 - 60)

Ribosomal_S15

Ribosomal_S15: Ribosomal protein S15 (66 - 150)

  • 0
  • 100
  • 151 a.a.
Protein Preferred Names Protein Names

40S ribosomal protein S13

  • small ribosomal subunit protein uS15

RPS13 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
RPS13 P62277 MAP3K14 Homo sapiens Q99558
TAP
14743216
Intra
RPS13 P62277 PDCD4 Homo sapiens Q53EL6
Pull Down
12054647
Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant RPS13 Proteins

Cat. No. Product Name Accession Purity
HY-P71683 RPS13 Protein, Human (GST) P62277 (R3-A151) ≥ 90%, as determined by reducing SDS-PAGE.

Related Diseases

Diseases Alias
Osgood-Schlatter'S Disease

  • Osgood-Schlatter Disease

  • Juvenile Osteochondrosis Of Tibial Tubercle

  • Osteochondrosis

  • Osteochondritis Of Tibial Tubercle

  • Osteochondrosis Of Proximal Tibia

  • Aseptic Necrosis Of The Tibial Tubercle

  • Osteochondrosis Of The Tibial Tubercle

  • Osteochondritis Juvenilis
Diamond-Blackfan Anemia

  • Congenital Pure Red Cell Aplasia

  • Aase Syndrome

  • Erythrogenesis Imperfecta

  • Anemia, Diamond-Blackfan

  • Congenital Hypoplastic Anemia

  • Aase-Smith Ii Syndrome

  • Bds

  • Blackfan-Diamond Anemia

  • Congenital Prca

  • Congenital Hypoplastic Anemia, Blackfan-Diamond Type

  • Dba

  • Blackfan - Diamond Syndrome

  • Chronic Constitutional Pure Red Cell Anaemia

  • Anemia Diamond Blackfan Type

  • Anemia Congenital Erythroid Hypoplastic

  • Aregenerative Anemia Chronic Congenital

  • Blackfan Diamond Syndrome

  • Red Cell Aplasia, Pure Hereditary

  • Aase-Smith Syndrome Ii

  • Bda

  • Blackfan Diamond Anemia

  • Blackfan-Diamond Disease

  • Blackfan-Diamond Syndrome

  • Chronic Congenital Agenerative Anemia

  • Congenital Erythroid Hypoplastic Anemia

  • Congenital Hypoplastic Anemia Of Blackfan And Diamond

  • Congenital Pure Red Cell Anemia

  • Hypoplastic Congenital Anemia

  • Inherited Erythroblastopenia

  • Pure Hereditary Red Cell Aplasia

  • Anemia, Hypoplastic, Congenital

  • Anemia Hypoplastic Congenital

  • Fanconi Anemia

  • Constitutional Aplastic Anemia

  • Diamond-Blackfan Anemia 1

  • Aase Smith Syndrome 2

  • Congenital Red Cell Aplasia

  • Red Cell Aplasia Of Infants

  • Pure Red Cell Aplasia Of Infants

  • Congenital Red Cell Aplastic Anaemia

  • Congenital Pure Red Cell Anaemia

  • Congenital Erythroid Hypoplasia

  • Pearson Marrow-Pancreas Syndrome
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS12223 RPS13 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS19479 Rps13 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS25972 Rps13 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Rattus norvegicus RPS13 RGD RGD:621027
Macaca mulatta RPS13 VGNC VGNC:107637
Mus musculus RPS13 MGD MGI:1915302
Others RPS13 NCBI