S100A6 - S100 calcium binding protein A6 Gene

Also Known as 2A9; PRA; 5B10; CABP; CACY; S10A6

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 6277

About S100A6

Cytogenetic location: 1q21.3 Genomic coordinates (GRCh38): 1:153,534,599-153,535,991 (from NCBI)

This gene has 5 transcripts (splice variants), 268 orthologues and 21 paralogues. Broad expression in colon (RPKM 705.5), lung (RPKM 524.4) and 23 other tissues.

Summary

The protein encoded by this gene is a member of the S100 family of proteins containing 2 EF-hand calcium-binding motifs. S100 proteins are localized in the cytoplasm and/or nucleus of a wide range of cells, and involved in the regulation of a number of cellular processes such as cell cycle progression and differentiation. S100 genes include at least 13 members which are located as a cluster on chromosome 1q21. This protein may function in stimulation of Ca2+-dependent Insulin release, stimulation of Prolactin secretion, and exocytosis. Chromosomal rearrangements and altered expression of this gene have been implicated in melanoma. [provided by RefSeq, Jul 2008]

S100A6 Products (1)

mRNA Protein Name
NM_014624.4 NP_055439.1 protein S100-A6

Gene Ontology

  • Molecular Function
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables S100 protein binding IPI
IPI: Inferred from physical interaction
10913138 GOA
enables calcium ion binding IDA
IDA: Inferred from direct assay
11937060 GOA
enables calcium-dependent protein binding IDA
IDA: Inferred from direct assay
10913138 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
10913138 GOA
enables protein homodimerization activity IDA
IDA: Inferred from direct assay
10913138 GOA
enables protein homodimerization activity IPI
IPI: Inferred from physical interaction
11937060 GOA
enables tropomyosin binding IDA
IDA: Inferred from direct assay
19724273 GOA
Cellular Component GO Annotation Evidence References Source
located in cytoplasm IDA
IDA: Inferred from direct assay
10913138 GOA
located in cytoplasmic side of plasma membrane IDA
IDA: Inferred from direct assay
19724273 GOA
located in cytosol IDA
IDA: Inferred from direct assay
19724273 GOA
located in nuclear envelope IDA
IDA: Inferred from direct assay
12601007 GOA
located in nucleus IDA
IDA: Inferred from direct assay
10913138 GOA
located in perinuclear region of cytoplasm IDA
IDA: Inferred from direct assay
12118070 GOA
located in ruffle IDA
IDA: Inferred from direct assay
10913138 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

S100A6 Protein Structure

S_100

S_100: S-100/ICaBP type calcium binding domain (5 - 42)

  • 0
  • 90 a.a.
Protein Preferred Names Protein Names

protein S100-A6

  • MLN 4

S100A6 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
S100A6 P06703 CACYBP Homo sapiens Q9HB71
Anti Tag CoIP
33961781
Intra
S100A6 P06703 CACYBP Homo sapiens Q9HB71
FPS
31837246
Intra
S100A6 P06703 TRPM4 Homo sapiens Q8TD43
FPS
31837246
Intra
S100A6 P06703 CEP43 Homo sapiens O95684
ITC
31837246
Intra
S100A6 P06703 FAM25C Homo sapiens B3EWG5
Y2H Prey Pooling
32296183
Intra
S100A6 P06703 FAM25C Homo sapiens B3EWG5
Y2H Array
32296183
Intra
S100A6 P06703 KPNA2 Homo sapiens P52292
EMSA Supershift
20965181
Intra
S100A6 P06703 MYH9 Homo sapiens P35579
FPS
31837246
Intra
S100A6 P06703 TP53 Homo sapiens P04637
FPS
31837246
Intra
S100A6 P06703 MDM2 Homo sapiens Q00987
SPR
20591429
Intra
S100A6 P06703 S100B Homo sapiens P04271
BRET
29997244
Intra
S100A6 P06703 S100B Homo sapiens P04271
Y2H
10913138
Intra
S100A6 P06703 PEX5 Homo sapiens P50542
Y2H Array
25416956
Intra
S100A6 P06703 PEX5 Homo sapiens P50542
Y2H Prey Pooling
25416956
Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant S100A6 Proteins

Cat. No. Product Name Accession Purity
HY-P71082 S100A6 Protein, Human (His) P06703 (M1-G90) ≥ 95%, as determined by reducing SDS-PAGE.

S100A6 Antibodies

Cat. No. Product Name Application Reactivity
HY-P80890 S100A6 Antibody (YA674) WB Human
HY-P80890A S100A6 Antibody (YA674)(PBS only) WB Human
HY-P86017 S100A6 Antibody (YA5709) IHC-P, ICC/IF, ELISA Human

Related Diseases

Diseases Alias
Pilomatrixoma

  • Pilomatricoma

  • PTR

  • Epithelioma Calcificans Of Malherbe

  • Benign Pilomatricoma

  • Calcifying Epithelioma Of Malherbe

  • Pilomatricoma, Somatic

  • Benign Pilomatrixoma

  • Malherbe Calcifying Epithelioma
Melanoma In Congenital Melanocytic Nevus

  • Malignant Melanoma In Congenital Melanocytic Nevus

  • Melanocytic Nevi

  • Nevi Melanocytic
Cutaneous Ganglioneuroma

  • Ganglioneuroma Of Skin
Retinitis Pigmentosa 61

  • RP61

  • Retinitis Pigmentosa, Type 61
Endometrial Cancer

  • Endometrial Carcinoma

  • Endometrial Neoplasm

  • Malignant Neoplasm Of Endometrium

  • Endometrioid Carcinoma

  • Endometrial Neoplasms

  • Carcinoma, Endometrioid

  • Endometrial Cancer, Familial

  • Endometrial Carcinoma, Somatic

  • Endometrial Cancer, Susceptibility To

  • Endometrial Ca

  • Malignant Endometrial Neoplasm

  • Neoplasm Of Endometrium

  • Primary Malignant Neoplasm Of Endometrium

  • Tumor Of Endometrium

  • Carcinoma Of The Endometrium

  • Endometrioid Carcinoma Of Female Reproductive System

  • ENDMC

  • Carcinoma Endometrioid

  • Endometrial Cancers

  • Cancer, Endometrial

  • Uterine Corpus Cancer
Malignant Peripheral Nerve Sheath Tumor

  • Mpnst

  • Malignant Neurilemmoma

  • Neurofibrosarcoma

  • Malignant Neurofibroma

  • Malignant Schwannoma

  • Neurogenic Sarcoma

  • Schwannoma, Malignant

  • Malignant Neoplasm Of The Peripheral Nerve Sheath

  • Malignant Peripheral Nerve Sheath Tumors
Androgen Insensitivity Syndrome

  • Androgen Resistance Syndrome

  • AIS

  • Testicular Feminization Syndrome

  • Androgen Receptor Deficiency

  • Dhtr Deficiency

  • Dihydrotestosterone Receptor Deficiency

  • Ar Deficiency

  • Testicular Feminization

  • Tfm

  • Androgen Insensitivity

  • Androgen-Insensitivity Syndrome

  • Goldberg-Maxwell Syndrome

  • Complete Androgen Insensitivity Syndrome

  • Cais

  • Feminisation - Testicular

  • Goldberg - Maxwell Syndrome

  • Androgen Insensitivity Syndrome, Complete

  • Morris Syndrome

  • Ary

  • AR

  • Insensitivity Syndrome, Androgen

  • Androgen Insensitivity Nos
Epidermoid Cysts

  • Epidermoid Cyst

  • Sebaceous Cyst

  • Epidermal Inclusion Cyst

  • Epidermal Cyst
Papillary Hidradenoma

  • Tubular Sweat Gland Adenomas
Oesophagostomiasis

  • Infection By Oesophagostomum

  • Oesophagostomosis
Melanoma

  • Malignant Melanoma

  • Cutaneous Melanoma

  • Naevocarcinoma

  • Malignant Melanomas
Pancreatic Cancer

  • Pancreatic Carcinoma

  • Carcinoma Of Pancreas

  • Familial Pancreatic Carcinoma

  • Pancreatic Neoplasm

  • Pancreatic Carcinoma, Familial

  • Malignant Neoplasm Of Pancreas

  • Pancreatic Acinar Carcinoma

  • Pancreatic Tumor

  • Familial Pancreatic Cancer

  • Neoplasm Of The Pancreas

  • Cancer Of The Pancreas

  • Pancreatic Carcinoma, Somatic

  • Pancreatic Cancer, Somatic

  • Ca Body Of Pancreas

  • Ca Head Of Pancreas

  • Ca Tail Of Pancreas

  • Malignant Neoplasm Of Body Of Pancreas

  • Malignant Neoplasm Of Head Of Pancreas

  • Malignant Neoplasm Of Tail Of Pancreas

  • Pancreas Neoplasm

  • Exocrine Cancer

  • Exocrine Pancreas Carcinoma

  • Hereditary Pancreatic Cancer

  • Hereditary Pancreatic Carcinoma

  • PNCA

  • Pancreatic Cancer, Susceptibility To

  • Carcinoma Of Head Of Pancreas

  • Pancreatic Neoplasms

  • Pancreatic Tumors

  • Cancer, Pancreatic

  • Cancer Of Pancreas

  • Mixed Islet Cell With Exocrine Carcinoma Of Unspecified Site
Gastric Cancer

  • Stomach Cancer

  • Gastric Carcinoma

  • Stomach Carcinoma

  • Gastric Cancer, Somatic

  • Gastric Neoplasm

  • Carcinoma Of Stomach

  • Stomach Neoplasms

  • Malignant Neoplasm Of Stomach

  • Gastric Cancer Risk After H. Pylori Infection

  • Cancer Of The Stomach

  • Adult Stomach Cancer

  • Adult Stomach Carcinoma

  • GASC

  • Gastric Cancer Intestinal

  • Gastric Cancers

  • Gastric Carcinomas

  • Cancer, Gastric

  • Stomach Neoplasm

  • Malignant Neoplasm Of Body Of Stomach

  • Malignant Tumor Of Lesser Curve Of Stomach

  • Gastrocarcinoma Of Unspecified Site

  • Leather Bottle Stomach

  • Carcinoma Of Fundus Of Stomach

  • Cancer Of Fundus Of Stomach

  • Primary Malignant Neoplasm Of Body Of Stomach

  • Cancer Of Body Of Stomach

  • Primary Malignant Neoplasm Of Pyloric Antrum

  • Pyloric Antrum Cancer

  • Malignant Tumour Of Stomach
Trachea Leiomyoma

  • Tracheal Neoplasms

  • Leiomyoma Of The Trachea

  • Tracheal Neoplasm

  • Tracheal Leiomyoma
Endometrial Stromal Sarcoma

  • Ess

  • Endometrial Stromal Sarcoma, High Grade

  • Undifferentiated Endometrial Sarcoma

  • Stromal Sarcoma Of The Corpus Uteri

  • Sarcoma Endometrial Stromal

  • Sarcoma, Endometrial Stromal

  • Undifferentiated Stromal Sarcoma
Anaplastic Astrocytoma

  • Grade Iii Astrocytoma

  • Astrocytoma, Anaplastic

  • Grade Iii Astrocytic Tumor
Pancreas Disease

  • Abnormality Of The Pancreas

  • Pancreatic Diseases
Melanoma, Uveal

  • Uveal Melanoma

  • Choroidal Melanoma

  • Melanoma Of Uvea

  • Iris Melanoma

  • Malignant Melanoma Of Choroid

  • Malignant Melanoma Of Iris
Breast Cancer

  • Breast Carcinoma

  • Male Breast Cancer

  • Breast Cancer, Familial

  • Malignant Neoplasm Of Breast

  • Breast Cancer, Susceptibility To

  • Breast Cancer, Early-Onset

  • Malignant Tumor Of Breast

  • Carcinoma Of Male Breast

  • Breast Cancer, Invasive Ductal

  • Breast Cancer, Protection Against

  • Breast Cancer, Somatic

  • Breast Cancer, Male

  • Breast Cancer, Lobular, Somatic

  • Breast Tumor

  • Mammary Cancer

  • Mammary Tumor

  • Malignant Neoplasm Of Male Breast

  • Mammary Carcinoma

  • Male Breast Carcinoma

  • Familial Cancer Of Breast

  • Invasive Ductal Breast Carcinoma

  • Breast Cancer Susceptibility

  • Breast Cancer, Male, Susceptibility To

  • Breast Cancer, Early-Onset, Susceptibility To

  • Malignant Tumor Of The Breast

  • Mammary Neoplasm

  • Primary Breast Cancer

  • Neoplasm Of Male Breast

  • Carcinoma Of Breast

  • Breast Cancer In Men

  • Familial Breast Cancer

  • Cancer Of Breast

  • BC

  • Breast Cancer Familial

  • Breast Cancer Familial Male

  • Breast Cancer, Familial Male

  • Breast Male Carcinoma

  • Breast Neoplasms

  • Breast Neoplasms, Male

  • Mammary Tumors

  • Mammary Carcinomas

  • Cancer, Breast

  • Cancer, Breast, Susceptibility

  • Invasive Breast Ductal Carcinoma

  • Breast Neoplasm

  • Susceptibility To Breast Cancer

  • Mammary Neoplasms

  • Animal Mammary Neoplasms

  • Primary Malignant Neoplasm Of Breast

  • Infiltrating Ductal Carcinoma Of Breast

  • Infiltrating Duct Carcinoma Of Unspecified Site

  • Infiltrating Ductular Carcinoma Of Unspecified Site

  • Invasive Breast Carcinoma Of No Special Type

  • Microinvasive Carcinoma Of Breast

  • Carcinoma With Apocrine Differentiation
Ovarian Cancer

  • Ovarian Carcinoma

  • Ovarian Neoplasm

  • Malignant Tumour Of Ovary

  • Cancer Of The Ovary

  • Epithelial Ovarian Cancer

  • Neoplasm Of Ovary

  • Ovarian Neoplasms

  • Ovarian Cancers

  • Malignant Neoplasm Of Ovary

  • Primary Malignant Neoplasm Of Ovary

  • Ovarian Cancer, Somatic

  • Malignant Ovarian Tumor

  • Ovary Neoplasm

  • Primary Ovarian Cancer

  • Tumor Of The Ovary

  • Malignant Neoplasm Of The Ovary

  • Malignant Tumor Of The Ovary

  • Ovarian Malignant Tumor

  • OC

  • Ovarian Carcinomas

  • Cancer, Ovarian

  • Cancer Of Ovary

  • Ovary Cancer

  • Ca Ovary
Amyotrophic Lateral Sclerosis 1

  • Amyotrophic Lateral Sclerosis

  • ALS

  • Lou Gehrig Disease

  • Amyotrophic Lateral Sclerosis Type 1

  • Charcot Disease

  • ALS1

  • Amyotrophic Lateral Sclerosis, Susceptibility To

  • Fals

  • Lou Gehrig'S Disease

  • Mnd

  • Motor Neuron Disease

  • Familial Amyotrophic Lateral Sclerosis

  • Amyotrophic Lateral Sclerosis 1, Familial

  • Amyotrophic Lateral Sclerosis 1, Autosomal Dominant

  • Motor Neuron Disease, Bulbar

  • Motor Neurone Disease

  • Amyotrophic Lateral Sclerosis With Dementia

  • Dementia With Amyotrophic Lateral Sclerosis

  • Motor Neuron Disease, Amyotrophic Lateral Sclerosis

  • Sclerosis, Lateral, Amyotrophic

  • Sclerosis, Lateral, Amyotrophic, Type 1

  • Amyotrophic Sclerosis

  • Als - [Amyotrophic Lateral Sclerosis]

  • Wasting Palsy

  • Amyotrophic Paralysis

  • Amyotrophy Lateral Sclerosis

  • Wasting Paralysis

  • Spinal Progressive Amyotrophy

  • Progressive Atrophic Paralysis
Meningioma, Familial

  • Meningioma

  • Familial Meningioma

  • Meningioma, Familial, Susceptibility To

  • Meningeal Neoplasm

  • Meningeal Neoplasms

  • Meningiomas

  • Meningioma, Nf2-Related, Somatic

  • Meningioma, Sis-Related

  • Meningothelial Cell Tumor

  • Neoplasm Of The Meninges

  • Primary Meningeal Tumor

  • Familial Multiple Meningioma

  • MNGMA

  • Meningioma, Benign, No Icd-O Subtype

  • Intracranial Meningioma

  • Meningothelial Cell Neoplasm

  • Supratentorial Meningioma

  • Primary Neoplasm Of Spinal Meninges

  • Benign Intracranial Meningioma

  • Benign Meningioma

  • Meningeal Tumours

  • Meningeal Sarcoma Of Unspecified Site

  • Meningothelial Sarcoma Of Unspecified Site
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS12382 S100A6 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS17386 S100a6 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS23841 S100a6 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Mus musculus S100A6 MGD MGI:1339467
Rattus norvegicus S100A6 RGD RGD:620264
Canis familiaris S100A6 VGNC VGNC:45832
Macaca mulatta S100A6 VGNC VGNC:76960
Others S100A6 NCBI