CXCL5 - C-X-C motif chemokine ligand 5 Gene

Also Known as SCYB5; ENA-78

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 6374

About CXCL5

Cytogenetic location: 4q13.3 Genomic coordinates (GRCh38): 4:73,995,642-73,998,677 (from NCBI)

This gene has 1 transcript (splice variant), 32 orthologues and 12 paralogues. Biased expression in appendix (RPKM 23.4), urinary bladder (RPKM 8.7) and 5 other tissues.

Summary

This gene encodes a protein that is a member of the CXC subfamily of chemokines. Chemokines, which recruit and activate leukocytes, are classified by function (inflammatory or homeostatic) or by structure. This protein is proposed to bind the G-protein coupled receptor chemokine (C-X-C motif) receptor 2 to recruit neutrophils, to promote angiogenesis and to remodel connective tissues. This protein is thought to play a role in Cancer cell proliferation, migration, and invasion. [provided by RefSeq, May 2013]

CXCL5 Products (1)

mRNA	Protein	Name
NM_002994.5	NP_002985.1	C-X-C motif chemokine 5 precursor

Gene Ontology

Molecular Function

Molecular Function GO Annotation	Evidence	References	Source
enables identical protein binding	IDA IDA: Inferred from direct assay	24695525	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	32296183	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

CXCL5 Protein Structure

IL8

0
100
114 a.a.

Protein Preferred Names	Protein Names
C-X-C motif chemokine 5	chemokine (C-X-C motif) ligand 5

CXCL5 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	CXCL5	P42830	MEOX2	Homo sapiens	Q6FHY5	Y2H Prey Pooling	32296183
Intra	CXCL5	P42830	MEOX2	Homo sapiens	Q6FHY5	Validated Y2H	32296183
Intra	CXCL5	P42830	MEOX2	Homo sapiens	Q6FHY5	Y2H Array	32296183
Intra	CXCL5	P42830	ACTN3	Homo sapiens	Q08043	Validated Y2H	32296183

Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant CXCL5 Proteins

Cat. No.	Product Name	Accession	Purity
HY-P7157	ENA-78/CXCL5 Protein, Human (HEK293)	P42830 (A37-N114)	≥ 95%, as determined by reducing SDS-PAGE.
HY-P7158	ENA-78/CXCL5 Protein, Human	P42830 (R45-N114)	≥ 95%, as determined by reducing SDS-PAGE.
HY-P700047AF	Animal-Free ENA-78/CXCL5 Protein, Human (His)	P42830 (R45-N114)	≥ 95%, as determined by reducing SDS-PAGE.

CXCL5 Antibodies

Cat. No.	Product Name	Application	Reactivity
HY-P81179	CXCL5 Antibody (YA3504)	WB, ICC/IF, IP	Human
HY-P81179A	CXCL5 Antibody (YA3504)(PBS only)	WB, ICC/IF, IP	Human

Related Diseases

Diseases	Alias
Pulmonary Sarcoidosis	Sarcoidosis, Pulmonary Lung Sarcoidosis Sarcoidosis Pulmonary Lung Sarcoid Sarcoidosis In Lung
Extrinsic Allergic Alveolitis	Hypersensitivity Pneumonitis Alveolitis, Extrinsic Allergic Alveolitis Allergic Interstitial Pneumonitis Allergic Pneumonitis Extrinsic Allergic Pneumonia Hypersensitivity Pneumonitis Hp Pneumonitis Hypersensitivity Allergic Alveolitis Extrinsic Allergic Alveolitis Nos Airway Obstruction With Allergic Alveolitis Unspecified Allergic Alveolitis And Pneumonitis Extrinsic Allergic Bronchiolo-Alveolitis Hypersensitivity Pneumonia Hypersensitivity Pneumonitis Nos Obstructive Lung Disease With Allergic Alveolitis Obstructive Lung Disorder With Hypersensitivity Pneumonitis Obstructive Lung Disorder With Allergic Alveolitis Obstructive Lung Disease With Hypersensitivity Pneumonitis
Gastritis	Acute Gastric Mucosal Erosion Erosive Gastritis Erosive Gastropathy Gastritis Erosive Idiopathic Erosive/Hemorrhagic Gastritis Inflammation Of Gastric Mucosa Gastroduodenitis Gastritis Nos Noninfectious Gastroenteritis Nonbacterial Gastroenteritis Of Infant Acute Gastric Infection Acute Simple Gastritis Chronic Antral Gastritis Chronic Fundal Gastritis Chronic Simple Gastritis Acute Gastroduodenitis Acute Antral Gastritis Acute Erosive Gastritis Bile Reflux Gastritis Gastritis Due To Biliary Reflux
Interstitial Lung Disease 2	Idiopathic Pulmonary Fibrosis Ipf Fibrocystic Pulmonary Dysplasia Pulmonary Fibrosis, Idiopathic Pulmonary Fibrosis, Idiopathic, Susceptibility To Cryptogenic Fibrosing Alveolitis ILD2 Idiopathic Pulmonary Fibrosis, Familial Fibrosing Alveolitis, Cryptogenic Uip Fibrosing Alveolitis Interstitial Pneumonitis, Usual Familial Idiopathic Pulmonary Fibrosis Idiopathic Fibrosing Alveolitis, Chronic Form Usual Interstitial Pneumonia Fibrosing Alveolitis Cryptogenic Hamman-Rich Disease Idiopathic Pulmonary Fibrosis Familial Interstitial Pneumonitis Usual Fibrosis Idiopathic Pulmonary Fibrosis, Pulmonary, Idiopathic Hamman-Rich Syndrome Chronic Idiopathic Pulmonary Fibrosis Acute Interstitial Pneumonia Interstitial Pulmonary Fibrosis Ipf - [Idiopathic Pulmonary Fibrosis] Idiopathic Lung Fibrosis Fibrosing Lung Disease Pulmonary Fibrosis Nos Fibrosing Pneumonitis
Hyper Ige Syndrome	Hyper-Ige Syndrome Hyper Immunoglobulin E Syndrome Hies Hyper-Ige Recurrent Infection Syndrome Hyperimmunoglobulin E Syndrome Hyper Ige Job Syndrome Hartnup Disease
Endometriosis	Endometriosis, Site Unspecified Endometrial Ectopia
Bacterial Meningitis	Meningitis, Bacterial Meningitis Bacterial Bm - [Bacterial Meningitis] Leptomeningitis Bacterial Pachymeningitis Bacterial Arachnoiditis Bacterial
Pneumonia	Acute Pneumonia Pneumonias Infectious Pneumonia Pn - [Pneumonia] Lobar Pneumonia Nos Multifocal Pneumonia Orthostatic Pneumonia Pneumonia Nos Chronic Pneumonia Nos Atypical Pneumonia Passive Pneumonia Purulent Pneumonia Interstitial Lobar Pneumonia Pneumonia, Unspecified Pneumonia Due To Chlamydia Pneumonia Due To Chlamydia Pneumoniae Pneumonia Due To E. Coli Escherichia Coli Lobar Pneumonia Pneumonia Due To H. Influenzae Pneumonia Due To Hemophilus Influenzae Bronchopneumonia Due To H. Influenzae Haemophilus Influenzae Lobar Pneumonia Bronchopneumonia Due To Hemophilus Influenzae Pseudomonal Pneumonia Pseudomonas Pneumonia Pseudomonas Lobar Pneumonia Staphylococcal Pneumonia Staphylococcus Pneumonia Acute Staphylococcal Pneumonia Staphylococcal Double Pneumonia Staphylococcal Lobar Pneumonia Staphylococcal Purulent Pneumonia Staphylococcal Bronchopneumonia Pneumococcal Pneumonia Pneumococcus Pneumonia Bronchopneumonia Due To S. Pneumoniae Pneumococcal Lobar Pneumonia Streptococcal Pneumoniae Pneumonia Streptococcus Pneumoniae Lobar Pneumonia Pyemic Pneumococcal Embolism With Pneumonia Bronchopneumonia Due To Streptococcus Pneumoniae Pneumonia Due To Streptococcus, Group B Group B Streptococcal Pneumonia Adenovirus Pneumonia Adenoviral Pneumonia Adenovirus Viral Pneumonia Pneumonia Respiratory Syncytial Viral Parainfluenza Viral Pneumonia Parainfluenzal Pneumonia Parainfluenza Virus Pneumonia Human Metapneumovirus Pneumonia Human Metapneumovirus Infection Resulting In Pneumonia Pneumocystis Pneumonia Plasma Cells Pneumonia
Rheumatoid Arthritis	RA Arthritis, Rheumatoid Rheumatoid Arthritis, Susceptibility To Arthritis Or Polyarthritis, Rheumatic Atrophic Arthritis Rheumatism Arthritis Rheumatoid Polyarthritis
Inflammatory Bowel Disease	Inflammatory Bowel Diseases Bowel Disease, Inflammatory
Sarcoidosis 1	Sarcoidosis Boeck Sarcoid Besnier-Boeck-Schaumann Disease SS1 Sarcoidosis, Susceptibility To, 1 Lymphogranulomatosis Hodgkin Disease Boeck'S Disease Boeck'S Sarcoid Schaumann'S Disease Or Syndrome Hutchinson-Boeck Disease Or Syndrome
Asymptomatic Neurosyphilis	Neurosyphilis Neurosyphilis, Asymptomatic
Asthma	Chronic Obstructive Asthma Asthma, Diminished Response To Antileukotriene Treatment In Bronchial Hyperreactivity Asthma, Susceptibility To Asthma, Bronchial Asthma, Protection Against Asthma, Nocturnal, Susceptibility To Nocturnal Asthma Asthma-Related Traits Asthma-Related Traits, Susceptibility To Asthma, Nocturnal Chronic Obstructive Asthma With Acute Exacerbation Chronic Obstructive Asthma With Status Asthmaticus Exercise Induced Asthma Exercise-Induced Asthma Bronchial Asthma Asthma, Exercise-Induced Idiosyncratic Asthma Unspecified Asthma With Acute Exacerbation Asthma, Unspecified, With Stated Status Asthmaticus Status Asthmaticus Nos Acute Severe Asthma Acute Severe Bronchial Asthma Status Asthma Status Post Asthmaticus
Colorectal Cancer	Colon Cancer Colorectal Carcinoma Colon Carcinoma Colorectal Cancer, Susceptibility To Carcinoma Of Colon CRC Colorectal Cancer With Chromosomal Instability, Somatic Colon Cancer, Somatic Colon Cancer, Susceptibility To Colonic Neoplasms Colorectal Neoplasms Colorectal Cancer, Somatic Colon Cancer, Advanced, Somatic Colonic Carcinoma Colorectal Carcinomas Colon Cancers Colorectal Cancers Cancer, Colorectal, Somatic Cancer, Colon Cancer, Colorectal, Susceptibility To Colorectal Neoplasm Colonic Neoplasm Malignant Tumor Of Colon
Chronic Congestive Splenomegaly

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (7)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-120501	B022	Inhibitor	99.27%	Unkown
HY-163475	CXCL-CXCR1/2-IN-1	Inhibitor	99.64%	Unkown
HY-149393	RIPK3-IN-3	Inhibitor	95.98%	Unkown
HY-176851	GSK1362	Inhibitor	96.38%	Unkown
HY-RS03393	CXCL5 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS16639	Cxcl5 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS24115	Cxcl6 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Inhibitory Antibodies (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-P99149	Anti-Mouse TNFR2 Antibody (TR75-54.7)	Inhibitor	98.864%	Unkown

Orthologs Information

Species	Symbol	Source	ID
Mus musculus	CXCL5	MGD	MGI:1096868
Others	CXCL5	NCBI