TP53AIP1 - tumor protein p53 regulated apoptosis inducing protein 1 Gene

Homo sapiens

Also known as P53AIP1

Gene ID: 63970 | Gene type: protein coding

About TP53AIP1

Cytogenetic location: 11q24.3 Genomic coordinates (GRCh38): 11:128,934,731-128,942,871 (from NCBI)

This gene has 6 transcripts (splice variants) and 14 orthologues. Biased expression in skin (RPKM 6.8) and esophagus (RPKM 1.6).

Summary

This gene is specifically expressed in the thymus, and encodes a protein that is localized to the mitochondrion. The expression of this gene is inducible by p53, and it is thought to play an important role in mediating p53-dependent Apoptosis. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Oct 2011]

TP53AIP1 Products(4)

mRNA	Protein	Name
NM_001195194.1	NP_001182123.1	p53-regulated apoptosis-inducing protein 1 isoform c
NM_001195195.2	NP_001182124.1	p53-regulated apoptosis-inducing protein 1 isoform b
NM_001251964.2	NP_001238893.1	p53-regulated apoptosis-inducing protein 1 isoform d
NM_022112.3	NP_071395.2	p53-regulated apoptosis-inducing protein 1 isoform a

TP53AIP1 Protein Structure

TPIP1

0
100
124 a.a.

Protein Preferred Names

Protein Names

p53-regulated apoptosis-inducing protein 1

Related Diseases

Diseases

Alias

Bartter Syndrome, Type 2, Antenatal

Bartter Disease Type 2	BARTS2
Hyperprostaglandin E Syndrome 2	Bartter Syndrome, Type 2
Bartter Syndrome Type 2	Hypokalemic Alkalosis With Hypercalciuria Antenatal 2
Hypokalemic Alkalosis With Hypercalciuria 2, Antenatal	Bartter Syndrome Type 2 Antenatal
Hypokalemic Alkalosis With Hypercalciuria 2 Antenatal	Bartter Syndrome Antenatal Type 2
Bartter Syndrome Type Ii	Bartter Syndrome 2, Antenatal
Abs2	Antenatal Bartter Syndrome 2
Bartter Syndrome 2	Bs2
Hyperprostanglandin E Syndrome 2	Bartter Syndrome, Antenatal , Type 2
Antley-Bixler Syndrome, Autosomal Dominant

Brain Cancer

Adult Brain Tumor	Malignant Neoplasm Of Brain
Brain Neoplasms	Brain Neoplasm
Neoplasm Of Brain	Primary Malignant Neoplasm Of Brain
Brain Tumors	Adult Malignant Brain Neoplasm
Brain Neoplasm, Adult	Bt - Brain Tumour
Malignant Brain Tumour	Malignant Primary Brain Neoplasm
Malignant Primary Brain Tumor	Malignant Tumor Of Adult Brain
Malignant Tumor Of Brain	Primary Brain Neoplasm
Primary Brain Tumor	Tumor Of The Brain
Brain Tumor, Adult	Brain Tumor Primary
Malignant Primary Brain Tumors	Primary Brain Tumors
Cancer, Brain	Brain Tumor, Primary

Prostate Cancer

Prostate Carcinoma	Prostate Cancer, Familial
Prostate Neoplasm	Prostate Cancer, Somatic
Prostate Cancer, Susceptibility To	Prostatic Cancer
Prostatic Neoplasms	Hereditary Prostate Cancer
Prostatic Neoplasm	Cancer Of Prostate
Carcinoma Of Prostate	Familial Prostate Cancer
Familial Prostate Carcinoma	Malignant Tumor Of Prostate
Malignant Neoplasm Of Prostate	Prostate Cancer, Familial, Susceptibility To
Malignant Tumor Of The Prostate	Ngp - New Growth Of Prostate
Tumor Of The Prostate	Prostate Cancer, Hereditary
Cancer Of The Prostate	Malignant Neoplasm Of The Prostate
Prostatic Carcinoma	PC
Prca	Cancer, Prostate
Malignant Prostatic Tumour	Malignant Tumour Of Prostate
Primary Prostate Cancer	Primary Malignant Neoplasm Of Prostate
Prostate Gland Cancer

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (2)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-124036	DS-7423	Inhibitor	99.75%	Unkown
HY-RS14914	TP53AIP1 Human Pre-designed siRNA Set A		/	Unkown

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