Ccnd2 - cyclin D2 Gene

Species: Rattus norvegicus

Gene Type: protein coding
Gene ID: 64033

Summary

Enables protein kinase binding activity. Involved in several processes, including cellular response to Insulin stimulus; response to estradiol; and response to testosterone. Predicted to be located in chromatin; cytosol; and nucleus. Predicted to be part of cyclin D2-CDK4 complex. Predicted to be active in cytoplasm and nucleus. Used to study transitional cell carcinoma. Biomarker of colon cancer; glaucoma; impotence; and nephritis. Human ortholog(s) of this gene implicated in ductal carcinoma in situ; invasive lobular carcinoma; prostate cancer; and transitional cell carcinoma. Orthologous to human CCND2 (cyclin D2). [provided by Alliance of Genome Resources, Apr 2022]

Ccnd2 Products (1)

mRNA Protein Name
NM_022267.2 NP_071603.2 G1/S-specific cyclin-D2

Gene Ontology

  • Molecular Function
  • Biological Process
Molecular Function GO Annotation Evidence References Source
enables protein kinase binding IPI
IPI: Inferred from physical interaction
15809057 RGD
Biological Process GO Annotation Evidence References Source
involved in G1/S transition of mitotic cell cycle IEP
IEP: Inferred from expression pattern
7926809 RGD
involved in G1/S transition of mitotic cell cycle IMP
IMP: Inferred from mutant phenotype
12130558 RGD
involved in cellular response to dexamethasone stimulus IEP
IEP: Inferred from expression pattern
27302109 RGD
involved in cellular response to follicle-stimulating hormone stimulus IEP
IEP: Inferred from expression pattern
15613482 RGD
involved in cellular response to growth hormone stimulus IEP
IEP: Inferred from expression pattern
12586844 RGD
involved in cellular response to insulin stimulus IEP
IEP: Inferred from expression pattern
16210359 RGD
involved in cellular response to testosterone stimulus IEP
IEP: Inferred from expression pattern
23028064 RGD
involved in liver development IEP
IEP: Inferred from expression pattern
15809057 RGD
involved in negative regulation of cardiac muscle cell differentiation IDA
IDA: Inferred from direct assay
27302109 RGD
involved in ovarian follicle development IEP
IEP: Inferred from expression pattern
17971845 RGD
involved in positive regulation of cardiac muscle cell proliferation IDA
IDA: Inferred from direct assay
27302109 RGD
involved in positive regulation of cell population proliferation IMP
IMP: Inferred from mutant phenotype
12130558 RGD
involved in positive regulation of epithelial cell proliferation IMP
IMP: Inferred from mutant phenotype
7811475 RGD
involved in regulation of neuron differentiation IEP
IEP: Inferred from expression pattern
8028782 RGD
involved in response to cAMP IEP
IEP: Inferred from expression pattern
9658398 RGD
involved in response to estradiol IEP
IEP: Inferred from expression pattern
12437973 RGD
involved in response to estrogen IEP
IEP: Inferred from expression pattern
9658398 RGD
involved in response to ethanol IEP
IEP: Inferred from expression pattern
12480138 RGD
involved in response to follicle-stimulating hormone IEP
IEP: Inferred from expression pattern
9658398 RGD
involved in response to human chorionic gonadotropin IEP
IEP: Inferred from expression pattern
9658398 RGD
involved in response to organic cyclic compound IEP
IEP: Inferred from expression pattern
7811475 RGD
involved in response to peptide hormone IEP
IEP: Inferred from expression pattern
14691013 RGD
involved in response to testosterone IEP
IEP: Inferred from expression pattern
15659706 RGD
involved in spermatogenesis IEP
IEP: Inferred from expression pattern
15659706 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

G1/S-specific cyclin-D2

  • vin-1 proto-oncogene

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (5)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-124129 10074-A4 Inhibitor 98.22% Unkown
HY-184654 MR-39 / Unkown
HY-RS02124 CCND2 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS17697 Ccnd2 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS24159 Ccnd2 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Ccnd2 NCBI NCBI:894