Casp8 - caspase 8 Gene

Also Known as CASP-8

Species: Rattus norvegicus

Gene Type: protein coding
Gene ID: 64044

About Casp8

Primary_assembly 9: 60,264,075-60,312,542 forward strand.mRatBN7.2:CM026982.1

This gene has 1 transcript (splice variant), 132 orthologues, 12 paralogues and is associated with 73 phenotypes. Biased expression in Thymus (RPKM 214.2), Spleen (RPKM 146.4) and 8 other tissues.

Summary

Enables cysteine-type endopeptidase activity; death receptor binding activity; and tumor necrosis factor receptor binding activity. Involved in several processes, including response to estradiol; response to ethanol; and response to lipopolysaccharide. Located in several cellular components, including cell body; cytosol; and membrane raft. Part of CD95 death-inducing signaling complex. Used to study pre-malignant neoplasm. Biomarker of several diseases, including heart disease (multiple); kidney disease (multiple); retinal detachment; sciatic neuropathy; and status epilepticus. Human ortholog(s) of this gene implicated in autoimmune lymphoproliferative syndrome type 2B; breast cancer; endocrine gland Cancer (multiple); esophagus adenocarcinoma; and primary immunodeficiency disease. Orthologous to human CASP8 (Caspase 8). [provided by Alliance of Genome Resources, Apr 2022]

Casp8 Products (1)

mRNA Protein Name
NM_022277.1 NP_071613.1 caspase-8

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables cysteine-type endopeptidase activity IDA
IDA: Inferred from direct assay
16493077 RGD
enables death receptor binding IPI
IPI: Inferred from physical interaction
17518537 RGD
enables protein binding IPI
IPI: Inferred from physical interaction
12191471 RGD
enables protein-containing complex binding IPI
IPI: Inferred from physical interaction
17518537 RGD
enables tumor necrosis factor receptor binding IPI
IPI: Inferred from physical interaction
20649583 RGD
Biological Process GO Annotation Evidence References Source
involved in cellular response to organic cyclic compound IEP
IEP: Inferred from expression pattern
16987298 RGD
involved in positive regulation of neuron apoptotic process IMP
IMP: Inferred from mutant phenotype
10197541 RGD
involved in protein processing IDA
IDA: Inferred from direct assay
16493077 RGD
involved in response to cobalt ion IEP
IEP: Inferred from expression pattern
18598848 RGD
involved in response to estradiol IEP
IEP: Inferred from expression pattern
18598848 RGD
involved in response to ethanol IDA
IDA: Inferred from direct assay
18269875 RGD
involved in response to lipopolysaccharide IEP
IEP: Inferred from expression pattern
18289516 RGD
Cellular Component GO Annotation Evidence References Source
part of CD95 death-inducing signaling complex IDA
IDA: Inferred from direct assay
16493077 RGD
located in cell body IDA
IDA: Inferred from direct assay
18096138 RGD
part of death-inducing signaling complex IDA
IDA: Inferred from direct assay
17518537 RGD
part of protein-containing complex IDA
IDA: Inferred from direct assay
15590916 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Casp8 Protein Structure

DED_Caspase_8_r1

DED_Caspase_8_r1: cd08333 (2 - 83)

DD

DD: cl14633 (97 - 178)

CASc

CASc: cd00032 (226 - 479)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 482 a.a.
Protein Preferred Names Protein Names

caspase-8

Casp8 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
Casp8 Q9JHX4 Fadd Rattus norvegicus Q8R2E7
Anti Bait CoIP
19001025
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (6)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-153161 CASP8-IN-1 Inhibitor 98.97% Unkown
HY-P10146 Ac-LETD-CHO Inhibitor / Unkown
HY-RS01965 CASP8 Human Pre-designed siRNA Set A / Unkown
HY-RS01966 Casp8 Mouse Pre-designed siRNA Set A / Unkown
HY-RS01967 Casp8 Rat Pre-designed siRNA Set A / Unkown
HY-RS01968 CASP8AP2 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Casp8 NCBI NCBI:841