Fadd - Fas associated via death domain Gene

Also Known as Mort1

Species: Rattus norvegicus

Gene Type: protein coding
Gene ID: 266610

Summary

Enables protease binding activity; receptor serine/threonine kinase binding activity; and tumor necrosis factor receptor superfamily binding activity. Involved in kidney development; regulation of necroptotic process; and response to alkaloid. Located in several cellular components, including cell body; membrane raft; and neuron projection. Part of CD95 death-inducing signaling complex. Used to study morphine dependence and prostatic hypertrophy. Biomarker of several diseases, including abdominal obesity-metabolic syndrome 1; brain glioma; mental depression; middle cerebral artery infarction; and obesity. Human ortholog(s) of this gene implicated in leukemia. Orthologous to human FADD (Fas associated via death domain). [provided by Alliance of Genome Resources, Apr 2022]

Fadd Products (1)

mRNA Protein Name
NM_152937.2 NP_690920.1 FAS-associated death domain protein

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables death receptor binding IPI
IPI: Inferred from physical interaction
17518537 RGD
enables protease binding IPI
IPI: Inferred from physical interaction
17518537 RGD
enables protein binding IPI
IPI: Inferred from physical interaction
19001025 RGD
enables protein-containing complex binding IPI
IPI: Inferred from physical interaction
17518537 RGD
enables receptor serine/threonine kinase binding IPI
IPI: Inferred from physical interaction
26038570 RGD
enables tumor necrosis factor receptor binding IPI
IPI: Inferred from physical interaction
20649583 RGD
Biological Process GO Annotation Evidence References Source
involved in behavioral response to cocaine IEP
IEP: Inferred from expression pattern
18580876 RGD
involved in kidney development IEP
IEP: Inferred from expression pattern
27561622 RGD
involved in regulation of necroptotic process IMP
IMP: Inferred from mutant phenotype
26038570 RGD
involved in response to cocaine IEP
IEP: Inferred from expression pattern
21925237 RGD
Cellular Component GO Annotation Evidence References Source
part of CD95 death-inducing signaling complex IDA
IDA: Inferred from direct assay
16493077 RGD
located in cell body IDA
IDA: Inferred from direct assay
18096138 RGD
part of death-inducing signaling complex IDA
IDA: Inferred from direct assay
17518537 RGD
part of protein-containing complex IDA
IDA: Inferred from direct assay
15590916 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

FAS-associated death domain protein

  • Fas (TNFRSF6)-associated via death domain

  • protein FADD

Fadd Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
Fadd Q8R2E7 Casp8 Rattus norvegicus Q9JHX4
Anti Bait CoIP
19001025
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (13)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-109582 ADT-OH 98.55% Unkown
HY-14622 Necrostatin 2 Inhibitor 99.78% Unkown
HY-148454 Necroptosis-IN-3 Inhibitor 99.53% Unkown
HY-132203 Necrostatin-34 Inhibitor 98.90% Unkown
HY-119369 FadD32 Inhibitor-1 Inhibitor / Unkown
HY-109582S ADT-OH-d4 / Unkown
HY-182307 OH14 Inducer / Unkown
HY-182597 Tracizoline / Unkown
HY-RS04665 FADD Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-168770 Cl-Necrostatin-1 Inhibitor / Unkown
HY-RS17138 Fadd Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS23584 Fadd Rat Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-W182790 Garsevil / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Fadd NCBI NCBI:8772