Tdo2 - tryptophan 2,3-dioxygenase Gene

Also Known as TO; Tdo

Species: Rattus norvegicus

Gene Type: protein coding
Gene ID: 64206

Summary

Enables several functions, including heme binding activity; oxygen binding activity; and tryptophan 2,3-dioxygenase activity. Involved in response to nitroglycerin and tryptophan catabolic process to acetyl-CoA. Human ortholog(s) of this gene implicated in Gilles de la Tourette syndrome and familial hypertryptophanemia. Orthologous to human TDO2 (tryptophan 2,3-dioxygenase). [provided by Alliance of Genome Resources, Apr 2022]

Tdo2 Products (1)

mRNA Protein Name
NM_022403.2 NP_071798.1 tryptophan 2,3-dioxygenase

Gene Ontology

  • Molecular Function
  • Biological Process
Molecular Function GO Annotation Evidence References Source
enables amino acid binding IDA
IDA: Inferred from direct assay
3899109 RGD
enables heme binding IDA
IDA: Inferred from direct assay
3400092 RGD
enables oxygen binding IDA
IDA: Inferred from direct assay
10719243 RGD
enables tryptophan 2,3-dioxygenase activity IDA
IDA: Inferred from direct assay
3400092 RGD
Biological Process GO Annotation Evidence References Source
involved in response to nitroglycerin IEP
IEP: Inferred from expression pattern
28659861 RGD
involved in tryptophan catabolic process to acetyl-CoA IDA
IDA: Inferred from direct assay
7236232 RGD
involved in tryptophan metabolic process IDA
IDA: Inferred from direct assay
3400092 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

tryptophan 2,3-dioxygenase

  • TRPO

  • tryptamin 2,3-dioxygenase

  • tryptophan 2,3-dioxygenase A

  • tryptophan oxygenase

  • tryptophan pyrrolase

  • tryptophan-23-dioxygenase

  • tryptophanase

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (11)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-133677 Mono(2-ethyl-5-hydroxyhexyl) phthalate 99.03% Unkown
HY-114319 β-Cembrenediol 98.16% Unkown
HY-170322 TDO2-IN-1 99.44% Unkown
HY-161996 IDO1-IN-25 Inhibitor / Unkown
HY-184027 IDO1/TDO-IN-12 Inhibitor / Unkown
HY-184028 IDO1-IN-37 Inhibitor / Unkown
HY-184079 TDO2-IN-2 / Unkown
HY-RS14331 TDO2 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-W1011921 TDO2-IN-3 / Unkown
HY-RS18976 Tdo2 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS25465 Tdo2 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Tdo2 NCBI NCBI:6999