Araf - A-Raf proto-oncogene, serine/threonine kinase Gene

Also Known as Araf1

Species: Rattus norvegicus

Gene Type: protein coding
Gene ID: 64363

Summary

Enables MAP kinase kinase kinase activity. Involved in protein phosphorylation. Located in cytosol. Orthologous to human ARAF (A-Raf proto-oncogene, serine/threonine kinase). [provided by Alliance of Genome Resources, Apr 2022]

Araf Products (2)

mRNA Protein Name
NM_001033663.2 NP_001028835.1 serine/threonine-protein kinase A-Raf isoform 2
NM_022532.2 NP_071977.1 serine/threonine-protein kinase A-Raf isoform 1

Gene Ontology

  • Molecular Function
  • Biological Process
Molecular Function GO Annotation Evidence References Source
enables MAP kinase kinase kinase activity IDA
IDA: Inferred from direct assay
10648842 RGD
Biological Process GO Annotation Evidence References Source
involved in protein phosphorylation IDA
IDA: Inferred from direct assay
10648842 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

serine/threonine-protein kinase A-Raf

  • A-Raf proto-oncogene serine/threonine-protein kinase

  • Raf related protein

  • Ras-binding protein

  • proto-oncogene A-Raf

  • proto-oncogene A-Raf-1

  • v-raf murine sarcoma 3611 viral oncogene homolog 1

  • v-raf oncogene homolog 1 (murine sarcoma 3611 virus)

Related Agents

  • Clinical Phase
  • Pre-clinical Phase

Clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Phase
HY-158115 NST-628 Inhibitor 99.35% Phase 1

Pre-clinical Phase

Bioactive Molecules (10)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-181067 IK-595 Inhibitor 98.55% Unkown
HY-162752 Anticancer agent 250 / Unkown
HY-169869 pan-Raf/RTK inhibitor 1 Inhibitor / Unkown
HY-178042 SS-3091 Inhibitor / Unkown
HY-186283 GNE-0749 Inhibitor / Unkown
HY-18652A Avutometinib potassium Inhibitor / Unkown
HY-E70103I exo-α-1,3-Arabinofuranosidase, Penicillium chrysogenum / Unkown
HY-RS00886 ARAF Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS18462 Araf Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS24943 Araf Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Araf NCBI NCBI:369