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PGA4 - pepsinogen A4 Gene

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 643847

About PGA4

Cytogenetic location: 11q12.2 Genomic coordinates (GRCh38): 11:61,222,347-61,231,694 (from NCBI)

This gene has 8 transcripts (splice variants), 165 orthologues and 9 paralogues. Restricted expression toward stomach (RPKM 23688.7).

Summary

This gene encodes a protein precursor of the digestive enzyme pepsin, a member of the peptidase A1 family of endopeptidases. The encoded precursor is secreted by gastric chief cells and undergoes autocatalytic cleavage in acidic conditions to form the active enzyme, which functions in the digestion of dietary proteins. This gene is found in a cluster of related genes on chromosome 11, each of which encodes one of multiple pepsinogens. Pepsinogen levels in serum may serve as a biomarker for atrophic gastritis and gastric Cancer. [provided by RefSeq, Jul 2015]

PGA4 Products (1)

mRNA	Protein	Name
NM_001079808.6	NP_001073276.1	pepsin A-4 preproprotein

Gene Ontology

Molecular Function

Molecular Function GO Annotation	Evidence	References	Source
enables protein binding	IPI IPI: Inferred from physical interaction	32296183	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

PGA4 Protein Structure

A1_Propeptide

Asp

0
100
200
300
388 a.a.

Protein Preferred Names	Protein Names
pepsin A-4	pepsinogen 4, group I (pepsinogen A)

PGA4 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	PGA4	P0DJD7	SPAG4	Homo sapiens	Q9NPE6	Validated Y2H	32296183
Intra	PGA4	P0DJD7	SPAG4	Homo sapiens	Q9NPE6	Y2H Array	32296183
Intra	PGA4	P0DJD7	STOM	Homo sapiens	P27105	Y2H Prey Pooling	32296183
Intra	PGA4	P0DJD7	STOM	Homo sapiens	P27105	Validated Y2H	32296183
Intra	PGA4	P0DJD7	STOM	Homo sapiens	P27105	Y2H Array	32296183
Intra	PGA4	P0DJD7	FNDC9	Homo sapiens	Q8TBE3	Y2H Prey Pooling	32296183
Intra	PGA4	P0DJD7	FNDC9	Homo sapiens	Q8TBE3	Validated Y2H	32296183
Intra	PGA4	P0DJD7	FNDC9	Homo sapiens	Q8TBE3	Y2H Array	32296183
Intra	PGA4	P0DJD7	CD74	Homo sapiens	P04233-2	Y2H Prey Pooling	32296183
Intra	PGA4	P0DJD7	CD74	Homo sapiens	P04233-2	Y2H Array	32296183
Intra	PGA4	P0DJD7	FIMP	Homo sapiens	Q96LL3	Validated Y2H	32296183
Intra	PGA4	P0DJD7	FIMP	Homo sapiens	Q96LL3	Y2H Array	32296183
Intra	PGA4	P0DJD7	FIMP	Homo sapiens	Q96LL3	Y2H Prey Pooling	32296183
Intra	PGA4	P0DJD7	AMIGO1	Homo sapiens	Q86WK6	Validated Y2H	32296183
Intra	PGA4	P0DJD7	AMIGO1	Homo sapiens	Q86WK6	Y2H Prey Pooling	32296183
Intra	PGA4	P0DJD7	AMIGO1	Homo sapiens	Q86WK6	Y2H Array	32296183
Intra	PGA4	P0DJD7	TMEM106C	Homo sapiens	Q9BVX2	Y2H Prey Pooling	32296183
Intra	PGA4	P0DJD7	TMEM106C	Homo sapiens	Q9BVX2	Validated Y2H	32296183
Intra	PGA4	P0DJD7	TMEM106C	Homo sapiens	Q9BVX2	Y2H Array	32296183
Intra	PGA4	P0DJD7	HHLA2	Homo sapiens	Q9UM44	Y2H Prey Pooling	32296183
Intra	PGA4	P0DJD7	HHLA2	Homo sapiens	Q9UM44	Validated Y2H	32296183
Intra	PGA4	P0DJD7	HHLA2	Homo sapiens	Q9UM44	Y2H Array	32296183
Intra	PGA4	P0DJD7	PVR	Homo sapiens	P15151	Y2H Prey Pooling	32296183
Intra	PGA4	P0DJD7	PVR	Homo sapiens	P15151	Validated Y2H	32296183
Intra	PGA4	P0DJD7	PVR	Homo sapiens	P15151	Y2H Array	32296183

Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant PGA4 Proteins

Cat. No.	Product Name	Accession	Purity
HY-P77135	Pepsinogen A4/PGA4 Protein, Human (HEK293, Fc)	P0DJD7/NP_001073276.1 (I16-A388)	≥ 80%, as determined by reducing SDS-PAGE.
HY-P77136	Pepsinogen A4/PGA4 Protein, Human (HEK293, His)	P0DJD7 (I16-A388)	≥ 95%, as determined by reducing SDS-PAGE.

Related Diseases

Diseases	Alias
Atrophic Gastritis	Gastritis, Atrophic Gastric Atrophy Gastritis Atrophic
Gastritis	Acute Gastric Mucosal Erosion Erosive Gastritis Erosive Gastropathy Gastritis Erosive Idiopathic Erosive/Hemorrhagic Gastritis Inflammation Of Gastric Mucosa Gastroduodenitis Gastritis Nos Noninfectious Gastroenteritis Nonbacterial Gastroenteritis Of Infant Acute Gastric Infection Acute Simple Gastritis Chronic Antral Gastritis Chronic Fundal Gastritis Chronic Simple Gastritis Acute Gastroduodenitis Acute Antral Gastritis Acute Erosive Gastritis Bile Reflux Gastritis Gastritis Due To Biliary Reflux
Chief Cell Adenoma	Chief Cell Adenoma Of Parathyroid Gland
Macular Degeneration, Age-Related, 10	ARMD10 Age Related Macular Degeneration 10 Macular Degeneration, Age-Related, Type 10
Gastric Cancer	Stomach Cancer Gastric Carcinoma Stomach Carcinoma Gastric Cancer, Somatic Gastric Neoplasm Carcinoma Of Stomach Stomach Neoplasms Malignant Neoplasm Of Stomach Gastric Cancer Risk After H. Pylori Infection Cancer Of The Stomach Adult Stomach Cancer Adult Stomach Carcinoma GASC Gastric Cancer Intestinal Gastric Cancers Gastric Carcinomas Cancer, Gastric Stomach Neoplasm Malignant Neoplasm Of Body Of Stomach Malignant Tumor Of Lesser Curve Of Stomach Gastrocarcinoma Of Unspecified Site Leather Bottle Stomach Carcinoma Of Fundus Of Stomach Cancer Of Fundus Of Stomach Primary Malignant Neoplasm Of Body Of Stomach Cancer Of Body Of Stomach Primary Malignant Neoplasm Of Pyloric Antrum Pyloric Antrum Cancer Malignant Tumour Of Stomach

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS10372	PGA4 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Mus musculus	PGA4	MGD	MGI:1915935