2. Gene
  3. Ctsb - cathepsin B Gene

Ctsb - cathepsin B Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Rattus norvegicus
Gene ID: 64529 | Gene type: protein coding

About Ctsb

Primary_assembly 15: 37,389,629-37,410,500 forward strand.mRatBN7.2:CM026988.1

This gene has 1 transcript (splice variant), 224 orthologues, 27 paralogues and is associated with 47 phenotypes. Biased expression in Kidney (RPKM 496.1), Spleen (RPKM 2256.) and 9 other tissues.

Summary

Enables several functions, including cysteine-type endopeptidase activity; kininogen binding activity; and protein self-association. Involved in several processes, including cellular response to mechanical stimulus; response to ethanol; and response to interleukin-4. Located in several cellular components, including apical plasma membrane; external side of plasma membrane; and sarcolemma. Colocalizes with caveola and perinuclear region of cytoplasm. Used to study hepatocellular carcinoma and high grade glioma. Biomarker of several diseases, including acute necrotizing pancreatitis; cerebrovascular disease (multiple); fascioliasis; fatty liver disease; and renal tubular acidosis. Human ortholog(s) of this gene implicated in diabetes mellitus. Orthologous to human CTSB (Cathepsin B). [provided by Alliance of Genome Resources, Apr 2022]

Ctsb Products(1)

mRNA Protein Name
NM_022597.2 NP_072119.2 cathepsin B preproprotein

Ctsb Protein Structure

Propeptide_C1

Propeptide_C1: pfam08127 (25 - 64)

Peptidase_C1A_CathepsinB

Peptidase_C1A_CathepsinB: cd02620 (80 - 327)

  • 0
  • 100
  • 200
  • 300
  • 339 a.a.
Protein Preferred Names Protein Names

cathepsin B

RSG-2

cathepsin B1

Recombinant Ctsb Proteins

Cat. No. Product Name Accession Purity
HY-P74345 Cathepsin B Protein, Rat (HEK293, His) Q6IN22 (H18-F339) ≥95%

Related Agents

Clinical Phase
Bioactive Molecules (2)
Cat. No. Product Name Effect
Purity Phase
HY-137978A Ezurpimtrostat hydrochloride Inhibitor 98.29% Phase 2
HY-137978 Ezurpimtrostat Inhibitor / Phase 2
Pre-clinical Phase
Bioactive Molecules (5)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-119293 K777 99.77% Unkown
HY-RS03322 CTSB Human Pre-designed siRNA Set A / Unkown
HY-RS03323 Ctsb Mouse Pre-designed siRNA Set A / Unkown
HY-RS03324 Ctsb Rat Pre-designed siRNA Set A / Unkown
HY-163029 CTSL/B-IN-1 Inhibitor / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Ctsb NCBI NCBI:1508
Mus musculus Ctsb NCBI NCBI:13030