Ctsb - cathepsin B Gene

Species: Rattus norvegicus

Gene Type: protein coding
Gene ID: 64529

About Ctsb

Primary_assembly 15: 37,389,629-37,410,500 forward strand.mRatBN7.2:CM026988.1

This gene has 1 transcript (splice variant), 224 orthologues, 27 paralogues and is associated with 47 phenotypes. Biased expression in Kidney (RPKM 496.1), Spleen (RPKM 2256.) and 9 other tissues.

Summary

Enables several functions, including cysteine-type endopeptidase activity; kininogen binding activity; and protein self-association. Involved in several processes, including cellular response to mechanical stimulus; response to ethanol; and response to interleukin-4. Located in several cellular components, including apical plasma membrane; external side of plasma membrane; and sarcolemma. Colocalizes with caveola and perinuclear region of cytoplasm. Used to study hepatocellular carcinoma and high grade glioma. Biomarker of several diseases, including acute necrotizing pancreatitis; cerebrovascular disease (multiple); fascioliasis; fatty liver disease; and renal tubular acidosis. Human ortholog(s) of this gene implicated in diabetes mellitus. Orthologous to human CTSB (Cathepsin B). [provided by Alliance of Genome Resources, Apr 2022]

Ctsb Products (1)

mRNA Protein Name
NM_022597.2 NP_072119.2 cathepsin B preproprotein

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables cysteine-type endopeptidase activity IDA
IDA: Inferred from direct assay
12788072 RGD
enables endopeptidase activity IDA
IDA: Inferred from direct assay
8702598 RGD
enables endopeptidase activity IMP
IMP: Inferred from mutant phenotype
8717430 RGD
enables identical protein binding IDA
IDA: Inferred from direct assay
7550115 RGD
enables kininogen binding IPI
IPI: Inferred from physical interaction
3356189 RGD
enables peptide binding IDA
IDA: Inferred from direct assay
8702598 RGD
enables protein binding IPI
IPI: Inferred from physical interaction
18938146 RGD
enables protein-containing complex binding IPI
IPI: Inferred from physical interaction
2470410 RGD
Biological Process GO Annotation Evidence References Source
involved in autophagy IEP
IEP: Inferred from expression pattern
18567942 RGD
involved in cellular response to mechanical stimulus IEP
IEP: Inferred from expression pattern
18464888 RGD
involved in neuron apoptotic process IMP
IMP: Inferred from mutant phenotype
19420257 RGD
involved in protein catabolic process IDA
IDA: Inferred from direct assay
8702598 RGD
involved in proteolysis IDA
IDA: Inferred from direct assay
12788072 RGD
involved in response to amine IEP
IEP: Inferred from expression pattern
17371271 RGD
involved in response to cytokine IEP
IEP: Inferred from expression pattern
19893052 RGD
involved in response to dexamethasone IEP
IEP: Inferred from expression pattern
8717430 RGD
involved in response to ethanol IEP
IEP: Inferred from expression pattern
17935147 RGD
involved in response to glucose IEP
IEP: Inferred from expression pattern
14722017 RGD
involved in response to interleukin-4 IEP
IEP: Inferred from expression pattern
18464888 RGD
involved in response to mechanical stimulus IEP
IEP: Inferred from expression pattern
17379854 RGD
involved in response to organic cyclic compound IEP
IEP: Inferred from expression pattern
18094625 RGD
involved in response to peptide hormone IEP
IEP: Inferred from expression pattern
18676994 RGD
involved in skeletal muscle tissue development IEP
IEP: Inferred from expression pattern
16497156 RGD
involved in spermatogenesis IEP
IEP: Inferred from expression pattern
9238520 RGD
Cellular Component GO Annotation Evidence References Source
located in apical plasma membrane IDA
IDA: Inferred from direct assay
12432075 RGD
located in caveola IDA
IDA: Inferred from direct assay
16497156 RGD
located in cell surface IDA
IDA: Inferred from direct assay
12432075 RGD
located in external side of plasma membrane IDA
IDA: Inferred from direct assay
2432075 RGD
located in extracellular region IDA
IDA: Inferred from direct assay
12432075 RGD
located in extracellular space IDA
IDA: Inferred from direct assay
2005374 RGD
located in perinuclear region of cytoplasm IDA
IDA: Inferred from direct assay
17218008 RGD
located in sarcolemma IDA
IDA: Inferred from direct assay
7043996 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Ctsb Protein Structure

Propeptide_C1

Propeptide_C1: pfam08127 (25 - 64)

Peptidase_C1A_CathepsinB

Peptidase_C1A_CathepsinB: cd02620 (80 - 327)

  • 0
  • 100
  • 200
  • 300
  • 339 a.a.
Protein Preferred Names Protein Names

cathepsin B

  • RSG-2

  • cathepsin B1

Recombinant Ctsb Proteins

Cat. No. Product Name Accession Purity
HY-P74345 Cathepsin B Protein, Rat (HEK293, His) Q6IN22 (H18-F339) ≥ 95%, as determined by reducing SDS-PAGE.

Related Agents

  • Clinical Phase
  • Pre-clinical Phase

Clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Phase
HY-178820 NM-002 / Phase 2

Pre-clinical Phase

Bioactive Molecules (10)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-119293 K777 Inhibitor 99.14% Unkown
HY-W074890 Palmitoylglycine Modulator 99.84% Unkown
HY-RS03322 CTSB Human Pre-designed siRNA Set A / Unkown
HY-119293A K777 tosylate Inhibitor / Unkown
HY-159172 HDAC3-IN-4 Inhibitor / Unkown
HY-178819 NM-001 / Unkown
HY-184662 Ferroptosis inducer-17 / Unkown
HY-RS03323 Ctsb Mouse Pre-designed siRNA Set A / Unkown
HY-RS03324 Ctsb Rat Pre-designed siRNA Set A / Unkown
HY-163029 CTSL/B-IN-1 Inhibitor / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Ctsb NCBI NCBI:1508