Fgf23 - fibroblast growth factor 23 Gene

Also Known as Fgf8b

Species: Mus musculus

Gene Type: protein coding
Gene ID: 64654

Summary

This gene encodes a member of the Fibroblast Growth Factor family. The encoded protein regulates phosphate homeostasis and vitamin D metabolism. Mutation of the related gene in humans causes autosomal dominant hypophosphatemic rickets (ADHR). The secreted protein is further cleaved into N- and C-terminal chains, which results in loss of function. [provided by RefSeq, Mar 2013]

Fgf23 Products (2)

mRNA Protein Name
NM_022657.5 NP_073148.1 fibroblast growth factor 23 precursor
NM_022657.5 NP_073148.1 fibroblast growth factor 23 precursor

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables fibroblast growth factor receptor binding IPI
IPI: Inferred from physical interaction
16436388 MGI
enables protein binding IPI
IPI: Inferred from physical interaction
17086194 MGI
enables type 1 fibroblast growth factor receptor binding IPI
IPI: Inferred from physical interaction
17086194 MGI
Biological Process GO Annotation Evidence References Source
involved in ERK1 and ERK2 cascade IDA
IDA: Inferred from direct assay
23523568 MGI
acts upstream of or within MAPK cascade IDA
IDA: Inferred from direct assay
24259513 MGI
involved in calcium ion homeostasis IDA
IDA: Inferred from direct assay
23523568 MGI
acts upstream of or within fibroblast growth factor receptor signaling pathway IPI
IPI: Inferred from physical interaction
16436388 MGI
acts upstream of or within intracellular phosphate ion homeostasis IMP
IMP: Inferred from mutant phenotype
15579309 MGI
involved in positive regulation of DNA-templated transcription IDA
IDA: Inferred from direct assay
17086194 MGI
involved in positive regulation of ERK1 and ERK2 cascade IDA
IDA: Inferred from direct assay
17086194 MGI
acts upstream of or within positive regulation of MAPKKK cascade by fibroblast growth factor receptor signaling pathway IGI
IGI: Inferred from genetic interaction
16436388 MGI
acts upstream of or within regulation of bone mineralization IMP
IMP: Inferred from mutant phenotype
15579309 MGI
involved in response to sodium phosphate IDA
IDA: Inferred from direct assay
23523568 MGI
Cellular Component GO Annotation Evidence References Source
located in extracellular space IDA
IDA: Inferred from direct assay
24259513 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

fibroblast growth factor 23

  • FGF-23

  • fibroblast growth factor 8b

Related Agents

  • Approval
  • Clinical Phase
  • Pre-clinical Phase

Approval

Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-N1428C Ferric citrate Activator / Unkown

Clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Phase
HY-159978 EOS789 Inhibitor 99.14% Phase 1

Pre-clinical Phase

Bioactive Molecules (10)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-125961 T3Inh-1 Inhibitor 99.93% Unkown
HY-150687 ZINC12409120 Inhibitor 99.95% Unkown
HY-173191 SK-124 Inhibitor 95.0% Unkown
HY-186173 MD-3-A45 Inhibitor 99.9% Unkown
HY-183371 ZINC13407541 Antagonist / Unkown
HY-RS04900 FGF23 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-W012856 3-Ethyltoluene / Unkown
HY-174698 Human FGF23 mRNA / Unkown
HY-RS16734 Fgf23 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS23171 Fgf23 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Fgf23 NCBI NCBI:8074