Rtn4r - reticulon 4 receptor Gene

Also Known as NgR; NgR1; NOGOR

Species: Mus musculus

Gene Type: protein coding

Gene ID: 65079

Summary

Enables chondroitin sulfate binding activity; heparin binding activity; and neuregulin receptor activity. Involved in several processes, including corpus callosum development; negative regulation of neuron projection development; and neuronal signal transduction. Acts upstream of or within axonogenesis. Located in several cellular components, including axonal growth cone; dendritic shaft; and neuronal cell body. Is integral component of plasma membrane. Is expressed in several structures, including cardiovascular system; forelimb bud; intestine; male reproductive gland or organ; and nervous system. Human ortholog(s) of this gene implicated in schizophrenia. Orthologous to human RTN4R (reticulon 4 receptor). [provided by Alliance of Genome Resources, Apr 2022]

Rtn4r Products (1)

mRNA	Protein	Name
NM_022982.3	NP_075358.1	reticulon-4 receptor precursor

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables chondroitin sulfate binding	IDA IDA: Inferred from direct assay	22406547	MGI
enables heparin binding	IDA IDA: Inferred from direct assay	22406547	MGI
enables neuregulin receptor activity	IDA IDA: Inferred from direct assay	22923615	MGI
enables protein binding	IPI IPI: Inferred from physical interaction	11201742	MGI

Biological Process GO Annotation	Evidence	References	Source
acts upstream of or within axonogenesis	IDA IDA: Inferred from direct assay	11201742	MGI
involved in corpus callosum development	IMP IMP: Inferred from mutant phenotype	27339102	MGI
involved in negative regulation of axon extension	IDA IDA: Inferred from direct assay	22923615	MGI
involved in negative regulation of axon regeneration	IMP IMP: Inferred from mutant phenotype	22406547	MGI
involved in negative regulation of neuron projection development	IMP IMP: Inferred from mutant phenotype	15504325	MGI
involved in neuronal signal transduction	IDA IDA: Inferred from direct assay	22923615	MGI
involved in positive regulation of GTPase activity	IDA IDA: Inferred from direct assay	22923615	MGI
involved in regulation of postsynapse assembly	EXP EXP: Inferred from Experiment	26748478	MGI
involved in regulation of postsynapse assembly	IDA IDA: Inferred from direct assay	26748478	MGI
involved in regulation of synapse assembly	IDA IDA: Inferred from direct assay	26838771	MGI
involved in regulation of synapse assembly	IMP IMP: Inferred from mutant phenotype	26838771	MGI

Cellular Component GO Annotation	Evidence	References	Source
located in axonal growth cone	IDA IDA: Inferred from direct assay	22923615	MGI
located in cell surface	IDA IDA: Inferred from direct assay	22325200	MGI
located in dendritic shaft	IDA IDA: Inferred from direct assay	22325200	MGI
is active in glutamatergic synapse	EXP EXP: Inferred from Experiment	26748478	MGI
is active in glutamatergic synapse	IDA IDA: Inferred from direct assay	26748478	MGI
is active in glutamatergic synapse	IMP IMP: Inferred from mutant phenotype	26838771	MGI
located in growth cone	IDA IDA: Inferred from direct assay	21817055	MGI
located in neuron projection	IDA IDA: Inferred from direct assay	22923615	MGI
located in neuronal cell body	IDA IDA: Inferred from direct assay	22923615	MGI
located in plasma membrane	IDA IDA: Inferred from direct assay	11201742	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names	Protein Names
reticulon-4 receptor	nogo66 receptor-1

Recombinant Rtn4r Proteins

Cat. No.	Product Name	Accession	Purity
HY-P71158	Nogo Receptor/NgR Protein, Mouse (HEK293, His)	Q99PI8 (C27-S447)	≥ 95%, as determined by reducing SDS-PAGE.

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS12334	RTN4R Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS18682	Rtn4r Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS25168	Rtn4r Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Rtn4r	NCBI	NCBI:65078