Pdzk1 - PDZ domain containing 1 Gene

Also Known as Clamp

Species: Rattus norvegicus

Gene Type: protein coding
Gene ID: 65144

Summary

Enables scavenger receptor binding activity. Predicted to be involved in several processes, including carnitine transport; positive regulation of protein targeting to membrane; and regulation of ion transport. Predicted to act upstream of or within in utero embryonic development. Located in apical plasma membrane; membrane raft; and microvillus membrane. Orthologous to human PDZK1 (PDZ domain containing 1). [provided by Alliance of Genome Resources, Apr 2022]

Pdzk1 Products (1)

mRNA Protein Name
NM_031712.1 NP_113900.1 Na(+)/H(+) exchange regulatory cofactor NHE-RF3

Gene Ontology

  • Molecular Function
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
16054660 RGD
enables protein-containing complex binding IPI
IPI: Inferred from physical interaction
21372499 RGD
enables scavenger receptor binding IDA
IDA: Inferred from direct assay
10829064 RGD
Cellular Component GO Annotation Evidence References Source
located in apical plasma membrane IDA
IDA: Inferred from direct assay
22904329 RGD
located in microvillus membrane IDA
IDA: Inferred from direct assay
22904329 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

Na(+)/H(+) exchange regulatory cofactor NHE-RF3

  • C-terminal linking and modulating protein

  • NHERF-3

  • Na(+)/H(+) exchanger regulatory factor 3

  • PDZ domain-containing protein 1

  • dietary Pi-regulated RNA-1

  • diphor-1

  • na/Pi cotransporter C-terminal-associated protein 1

  • naPi-Cap1

  • sodium-hydrogen exchanger

Pdzk1 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
Pdzk1 Q9JJ40 Syngap1 Rattus norvegicus Q9QUH6
Y2H
16054660
Intra
Pdzk1 Q9JJ40 Syngap1 Rattus norvegicus Q9QUH6
Anti Tag CoIP
16054660
Intra
Pdzk1 Q9JJ40 Klhl17 Rattus norvegicus Q8K430
Anti Tag CoIP
16054660
Cross
Pdzk1 Q9JJ40 Shkbp1 Mus musculus Q6P7W2
Anti Tag CoIP
16054660
Cross
Pdzk1 Q9JJ40 Shkbp1 Mus musculus Q6P7W2
Y2H
16054660
Intra
Pdzk1 Q9JJ40 Grin1 Rattus norvegicus P35439
Imaging
16054660
Intra
Pdzk1 Q9JJ40 Grin1 Rattus norvegicus P35439
Anti Bait CoIP
16054660
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (6)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS10305 PDZK1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS10306 PDZK1IP1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS20077 Pdzk1 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS21275 Pdzk1ip1 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS26580 Pdzk1 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS27794 Pdzk1ip1 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Pdzk1 NCBI NCBI:5174