Klhl17 - kelch-like family member 17 Gene

Species: Rattus norvegicus

Gene Type: protein coding
Gene ID: 246757

Summary

Enables POZ domain binding activity; actin filament binding activity; and molecular adaptor activity. Involved in actin Cytoskeleton organization and brain development. Located in several cellular components, including dendrite cytoplasm; neuronal cell body; and postsynaptic density. Orthologous to human KLHL17 (kelch like family member 17). [provided by Alliance of Genome Resources, Apr 2022]

Klhl17 Products (1)

mRNA Protein Name
NM_145671.2 NP_663704.1 kelch-like protein 17

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables POZ domain binding IPI
IPI: Inferred from physical interaction
12063253 RGD
enables actin filament binding IDA
IDA: Inferred from direct assay
12063253 RGD
enables molecular adaptor activity IDA
IDA: Inferred from direct assay
17062563 RGD
enables protein binding IPI
IPI: Inferred from physical interaction
16054660 RGD
Biological Process GO Annotation Evidence References Source
involved in actin cytoskeleton organization IDA
IDA: Inferred from direct assay
16054660 RGD
involved in regulation protein catabolic process at postsynapse IDA
IDA: Inferred from direct assay
17062563 RGD
involved in regulation protein catabolic process at postsynapse IMP
IMP: Inferred from mutant phenotype
17062563 RGD
Cellular Component GO Annotation Evidence References Source
located in actin cytoskeleton IDA
IDA: Inferred from direct assay
16054660 RGD
located in dendrite cytoplasm IDA
IDA: Inferred from direct assay
12063253 RGD
is active in glutamatergic synapse IDA
IDA: Inferred from direct assay
12063253 RGD
is active in glutamatergic synapse IMP
IMP: Inferred from mutant phenotype
17062563 RGD
located in neuronal cell body IDA
IDA: Inferred from direct assay
12063253 RGD
is active in postsynapse IDA
IDA: Inferred from direct assay
12063253 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

kelch-like protein 17

  • actinfilin

  • kelch-like 17

Klhl17 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Cross
Klhl17 Q8K430 Synpo Mus musculus Q8CC35-3
IF
37651441
Cross
Klhl17 Q8K430 Synpo Mus musculus Q8CC35-3
Anti Tag CoIP
37651441
Intra
Klhl17 Q8K430 Dlg4 Rattus norvegicus P31016
Anti Bait CoIP
16054660
Intra
Klhl17 Q8K430 Pdzk1 Rattus norvegicus Q9JJ40
Anti Tag CoIP
16054660
Intra
Klhl17 Q8K430 Pdzk1 Rattus norvegicus Q9JJ40
Y2H
16054660
Intra
Klhl17 Q8K430 Pdzk1 Rattus norvegicus Q9JJ40
Anti Bait CoIP
16054660
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS07360 KLHL17 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Klhl17 NCBI NCBI:339451