Piezo2 - piezo-type mechanosensitive ion channel component 2 Gene

Also Known as Fam38b; Fam38b2; 5930434P17; 9030411M15Rik; 9430028L06Rik

Species: Mus musculus

Gene Type: protein coding
Gene ID: 667742

Summary

Enables mechanosensitive cation channel activity. Involved in detection of mechanical stimulus involved in sensory perception. Acts upstream of or within cation transport and regulation of membrane potential. Predicted to be integral component of membrane. Predicted to be active in plasma membrane. Is expressed in dorsal root ganglion and lung. Human ortholog(s) of this gene implicated in distal arthrogryposis type 3 and distal arthrogryposis type 5. Orthologous to human PIEZO2 (piezo type mechanosensitive ion channel component 2). [provided by Alliance of Genome Resources, Apr 2022]

Piezo2 Products (1)

mRNA Protein Name
NM_001039485.4 NP_001034574.4 piezo-type mechanosensitive ion channel component 2

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables mechanosensitive monoatomic ion channel activity IDA
IDA: Inferred from direct assay
20813920 MGI
enables monoatomic cation channel activity IDA
IDA: Inferred from direct assay
20813920 MGI
enables protein binding IPI
IPI: Inferred from physical interaction
24662763 MGI
Biological Process GO Annotation Evidence References Source
involved in detection of mechanical stimulus involved in sensory perception IMP
IMP: Inferred from mutant phenotype
24717433 MGI
involved in monoatomic cation transport IMP
IMP: Inferred from mutant phenotype
20813920 MGI
acts upstream of or within regulation of membrane potential IDA
IDA: Inferred from direct assay
20813920 MGI
involved in response to mechanical stimulus IDA
IDA: Inferred from direct assay
38568807 MGI
involved in response to mechanical stimulus IMP
IMP: Inferred from mutant phenotype
24717433 MGI
Cellular Component GO Annotation Evidence References Source
located in cuticular plate IDA
IDA: Inferred from direct assay
38228630 MGI
located in neuronal cell body membrane IDA
IDA: Inferred from direct assay
38568807 MGI
located in stereocilium IDA
IDA: Inferred from direct assay
38228630 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

piezo-type mechanosensitive ion channel component 2

  • family with sequence similarity 38, member B

  • family with sequence similarity 38, member B2

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (6)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-P1410B D-GsMTx4 Inhibitor 99.44% Unkown
HY-P1410C D-GsMTx4 TFA Inhibitor 99.89% Unkown
HY-131018 Jedi2 99.93% Unkown
HY-RS16250 Piezo2 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-181467 KC159 Agonist 99.9% Unkown
HY-RS10484 PIEZO2 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Piezo2 NCBI NCBI:63895