SULT1E1 - sulfotransferase family 1E member 1 Gene

Also Known as EST; STE; EST-1; ST1E1

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 6783

About SULT1E1

Cytogenetic location: 4q13.3 Genomic coordinates (GRCh38): 4:69,821,122-69,860,145 (from NCBI)

This gene has 2 transcripts (splice variants), 616 orthologues and 12 paralogues. Biased expression in small intestine (RPKM 11.9), duodenum (RPKM 11.7) and 4 other tissues.

Summary

Sulfotransferase Enzymes catalyze the sulfate conjugation of many Hormones, neurotransmitters, drugs, and xenobiotic compounds. These cytosolic Enzymes are different in their tissue distributions and substrate specificities. The gene structure (number and length of exons) is similar among family members. This gene encodes a protein that transfers a sulfo moiety to and from estrone, which may control levels of estrogen receptors. [provided by RefSeq, Jul 2008]

SULT1E1 Products (1)

mRNA Protein Name
NM_005420.3 NP_005411.1 sulfotransferase 1.00E+01

Gene Ontology

  • Molecular Function
  • Biological Process
Molecular Function GO Annotation Evidence References Source
enables flavonol 3-sulfotransferase activity IDA
IDA: Inferred from direct assay
20056724 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
25416956 GOA
enables steroid sulfotransferase activity IDA
IDA: Inferred from direct assay
11884392 GOA
enables sulfotransferase activity IDA
IDA: Inferred from direct assay
19548878 GOA
Biological Process GO Annotation Evidence References Source
involved in 3'-phosphoadenosine 5'-phosphosulfate metabolic process IDA
IDA: Inferred from direct assay
23207770 GOA
involved in estrogen catabolic process IDA
IDA: Inferred from direct assay
23207770 GOA
involved in estrogen metabolic process IDA
IDA: Inferred from direct assay
11884392 GOA
involved in ethanol catabolic process IDA
IDA: Inferred from direct assay
23207770 GOA
involved in positive regulation of fat cell differentiation IMP
IMP: Inferred from mutant phenotype
24567372 GOA
acts upstream of or within sulfation IDA
IDA: Inferred from direct assay
19548878 GOA
involved in sulfation IDA
IDA: Inferred from direct assay
20056724 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

SULT1E1 Protein Structure

Sulfotransfer_1

Sulfotransfer_1: Sulfotransferase domain (37 - 286)

  • 0
  • 100
  • 200
  • 294 a.a.
Protein Preferred Names Protein Names

sulfotransferase 1E1

  • estrogen sulfotransferase

SULT1E1 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
SULT1E1 P49888 PDE9A Homo sapiens O76083-2
Y2H Prey Pooling
32296183
Intra
SULT1E1 P49888 PDE9A Homo sapiens O76083-2
Y2H Array
32296183
Intra
SULT1E1 P49888 PDE9A Homo sapiens O76083
Validated Y2H
25416956
Intra
SULT1E1 P49888 PDE9A Homo sapiens O76083
Y2H Prey Pooling
25416956
Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant SULT1E1 Proteins

Cat. No. Product Name Accession Purity
HY-P76099 SULT1E1 Protein, Human (His, solution) P49888 (N2-I294) ≥ 90%, as determined by reducing SDS-PAGE.

Related Diseases

Diseases Alias
Endometrial Cancer

  • Endometrial Carcinoma

  • Endometrial Neoplasm

  • Malignant Neoplasm Of Endometrium

  • Endometrioid Carcinoma

  • Endometrial Neoplasms

  • Carcinoma, Endometrioid

  • Endometrial Cancer, Familial

  • Endometrial Carcinoma, Somatic

  • Endometrial Cancer, Susceptibility To

  • Endometrial Ca

  • Malignant Endometrial Neoplasm

  • Neoplasm Of Endometrium

  • Primary Malignant Neoplasm Of Endometrium

  • Tumor Of Endometrium

  • Carcinoma Of The Endometrium

  • Endometrioid Carcinoma Of Female Reproductive System

  • ENDMC

  • Carcinoma Endometrioid

  • Endometrial Cancers

  • Cancer, Endometrial

  • Uterine Corpus Cancer
Skin Angiosarcoma

  • Angiosarcoma Of Skin

  • Hemangiosarcoma Of The Skin

  • Haemangiosarcoma Of Skin

  • Lymphangiosarcoma Of Skin

  • Cutaneous Angiosarcoma

  • Malignant Haemangioendothelioma Of Skin
Estrogen Excess

  • Hyperestrogenism
Clear Cell Adenoma
Breast Cancer

  • Breast Carcinoma

  • Male Breast Cancer

  • Breast Cancer, Familial

  • Malignant Neoplasm Of Breast

  • Breast Cancer, Susceptibility To

  • Breast Cancer, Early-Onset

  • Malignant Tumor Of Breast

  • Carcinoma Of Male Breast

  • Breast Cancer, Invasive Ductal

  • Breast Cancer, Protection Against

  • Breast Cancer, Somatic

  • Breast Cancer, Male

  • Breast Cancer, Lobular, Somatic

  • Breast Tumor

  • Mammary Cancer

  • Mammary Tumor

  • Malignant Neoplasm Of Male Breast

  • Mammary Carcinoma

  • Male Breast Carcinoma

  • Familial Cancer Of Breast

  • Invasive Ductal Breast Carcinoma

  • Breast Cancer Susceptibility

  • Breast Cancer, Male, Susceptibility To

  • Breast Cancer, Early-Onset, Susceptibility To

  • Malignant Tumor Of The Breast

  • Mammary Neoplasm

  • Primary Breast Cancer

  • Neoplasm Of Male Breast

  • Carcinoma Of Breast

  • Breast Cancer In Men

  • Familial Breast Cancer

  • Cancer Of Breast

  • BC

  • Breast Cancer Familial

  • Breast Cancer Familial Male

  • Breast Cancer, Familial Male

  • Breast Male Carcinoma

  • Breast Neoplasms

  • Breast Neoplasms, Male

  • Mammary Tumors

  • Mammary Carcinomas

  • Cancer, Breast

  • Cancer, Breast, Susceptibility

  • Invasive Breast Ductal Carcinoma

  • Breast Neoplasm

  • Susceptibility To Breast Cancer

  • Mammary Neoplasms

  • Animal Mammary Neoplasms

  • Primary Malignant Neoplasm Of Breast

  • Infiltrating Ductal Carcinoma Of Breast

  • Infiltrating Duct Carcinoma Of Unspecified Site

  • Infiltrating Ductular Carcinoma Of Unspecified Site

  • Invasive Breast Carcinoma Of No Special Type

  • Microinvasive Carcinoma Of Breast

  • Carcinoma With Apocrine Differentiation
Breast Disease

  • Breast Diseases
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (4)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-175266 MI1013 99.10% Unkown
HY-RS14019 SULT1E1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS18107 Sult1e1 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS24581 Sult1e1 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Mus musculus SULT1E1 MGD MGI:98431
Rattus norvegicus SULT1E1 RGD RGD:3776
Macaca mulatta SULT1E1 VGNC VGNC:100275
Bos taurus SULT1E1 VGNC VGNC:35467
Others SULT1E1 NCBI