Plpp3 - phospholipid phosphatase 3 Gene

Also Known as Lpp3; PRG-2; Ppab2b; Ppap2b; D4Bwg0538e; D4Bwg1535e; 1110003O22Rik; 2610002D05Rik

Species: Mus musculus

Gene Type: protein coding

Gene ID: 67916

Summary

Enables Integrin binding activity and sphingosine-1-phosphate Phosphatase activity. Involved in several processes, including negative regulation of protein phosphorylation; positive regulation of DNA-binding transcription factor activity; and protein stabilization. Acts upstream of or within several processes, including Bergmann glial cell differentiation; positive regulation of peptidyl-tyrosine phosphorylation; and regulation of signal transduction. Located in plasma membrane. Is expressed in several structures, including alimentary system; central nervous system; genitourinary system; limb; and sensory organ. Orthologous to human PLPP3 (phospholipid Phosphatase 3). [provided by Alliance of Genome Resources, Apr 2022]

Plpp3 Products (1)

mRNA	Protein	Name
NM_080555.2	NP_542122.1	phospholipid phosphatase 3

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables integrin binding	IDA IDA: Inferred from direct assay	16099422	MGI
enables lipid phosphatase activity	IMP IMP: Inferred from mutant phenotype	12925589	MGI
enables sphingosine-1-phosphate phosphatase activity	IMP IMP: Inferred from mutant phenotype	21319224	MGI

Biological Process GO Annotation	Evidence	References	Source
acts upstream of or within Bergmann glial cell differentiation	IMP IMP: Inferred from mutant phenotype	21319224	MGI
acts upstream of or within blood vessel development	IMP IMP: Inferred from mutant phenotype	12925589	MGI
acts upstream of or within cell adhesion	IDA IDA: Inferred from direct assay	16099422	MGI
acts upstream of or within cell-cell adhesion	IDA IDA: Inferred from direct assay	16099422	MGI
acts upstream of or within gastrulation with mouth forming second	IMP IMP: Inferred from mutant phenotype	12925589	MGI
involved in negative regulation of protein phosphorylation	IDA IDA: Inferred from direct assay	20123964	MGI
acts upstream of or within phospholipid metabolic process	IMP IMP: Inferred from mutant phenotype	12925589	MGI
involved in positive regulation of DNA-binding transcription factor activity	IDA IDA: Inferred from direct assay	20123964	MGI
acts upstream of or within positive regulation of peptidyl-tyrosine phosphorylation	IDA IDA: Inferred from direct assay	16099422	MGI
involved in protein stabilization	IDA IDA: Inferred from direct assay	20123964	MGI
acts upstream of or within regulation of Wnt signaling pathway	IDA IDA: Inferred from direct assay	12925589	MGI
acts upstream of or within regulation of sphingolipid mediated signaling pathway	IMP IMP: Inferred from mutant phenotype	21319224	MGI

Cellular Component GO Annotation	Evidence	References	Source
located in plasma membrane	IDA IDA: Inferred from direct assay	21319224	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names	Protein Names
phospholipid phosphatase 3	PAP-2b PAP2-beta PAP2b lipid phosphate phosphohydrolase 3 phosphatidate phosphohydrolase type 2b phosphatidic acid phosphatase 2b phosphatidic acid phosphatase type 2B

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS10736	PLPP3 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS20464	Plpp3 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS26973	Plpp3 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Plpp3	NCBI	NCBI:8613