Npc2 - NPC intracellular cholesterol transporter 2 Gene

Also Known as HE1; 2700012J19Rik

Species: Mus musculus

Gene Type: protein coding
Gene ID: 67963

Summary

Enables Cholesterol binding activity. Involved in Cholesterol efflux and intracellular Cholesterol transport. Located in lysosome. Is expressed in nervous system; respiratory system; and stomach. Used to study Niemann-Pick disease. Human ortholog(s) of this gene implicated in Niemann-Pick disease and Niemann-Pick disease type C2. Orthologous to human NPC2 (NPC intracellular Cholesterol transporter 2). [provided by Alliance of Genome Resources, Apr 2022]

Npc2 Products (1)

mRNA Protein Name
NM_023409.4 NP_075898.1 NPC intracellular cholesterol transporter 2 precursor

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables cholesterol binding IMP
IMP: Inferred from mutant phenotype
21315718 MGI
Biological Process GO Annotation Evidence References Source
involved in cholesterol efflux IMP
IMP: Inferred from mutant phenotype
21315718 MGI
acts upstream of or within cholesterol storage IMP
IMP: Inferred from mutant phenotype
21289032 MGI
involved in cholesterol transport IMP
IMP: Inferred from mutant phenotype
21315718 MGI
acts upstream of or within gene expression IMP
IMP: Inferred from mutant phenotype
21289032 MGI
involved in intracellular cholesterol transport IMP
IMP: Inferred from mutant phenotype
17018531 MGI
acts upstream of or within sterol metabolic process IMP
IMP: Inferred from mutant phenotype
21289032 MGI
acts upstream of or within sterol transport IMP
IMP: Inferred from mutant phenotype
21289032 MGI
Cellular Component GO Annotation Evidence References Source
is active in lysosome IDA
IDA: Inferred from direct assay
21289032 MGI
located in lysosome IDA
IDA: Inferred from direct assay
29514215 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

NPC intracellular cholesterol transporter 2

  • Niemann-Pick type C2

  • epididymal secretory protein E1

  • mE1

  • niemann Pick type C2 protein homolog

Recombinant Npc2 Proteins

Cat. No. Product Name Accession Purity
HY-P74693 Niemann Pick C2/NPC2 Protein, Mouse (HEK293, His) Q9Z0J0 (E20-S149) ≥ 95%, as determined by reducing SDS-PAGE.

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (6)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-111355 Cholesterol sulfate 99.71% Unkown
HY-W014780 α-Amylcinnamaldehyde 99.74% Unkown
HY-N15984 18:1-12:0 Biotin PC / Unkown
HY-RS09476 NPC2 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS17456 Npc2 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS23913 Npc2 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Npc2 NCBI NCBI:10577