TAF6 - TATA-box binding protein associated factor 6 Gene

Also Known as ALYUS; TAF2E; TAFII70; TAFII80; TAFII85; MGC:8964; TAFII-70; TAFII-80; TAF(II)70; TAF(II)80

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 6878

About TAF6

Cytogenetic location: 7q22.1 Genomic coordinates (GRCh38): 7:100,107,070-100,127,171 (from NCBI)

This gene has 71 transcripts (splice variants), 207 orthologues, 1 paralogue and is associated with 1 phenotype. Ubiquitous expression in testis (RPKM 19.4), endometrium (RPKM 14.3) and 25 other tissues.

Summary

Initiation of transcription by RNA polymerase II requires the activities of more than 70 polypeptides. The protein that coordinates these activities is transcription factor IID (TFIID), which binds to the core promoter to position the polymerase properly, serves as the scaffold for assembly of the remainder of the transcription complex, and acts as a channel for regulatory signals. TFIID is composed of the TATA-binding protein (TBP) and a group of evolutionarily conserved proteins known as TBP-associated factors or TAFs. TAFs may participate in basal transcription, serve as coactivators, function in promoter recognition or modify general transcription factors (GTFs) to facilitate complex assembly and transcription initiation. This gene encodes one of the smaller subunits of TFIID that binds weakly to TBP but strongly to TAF1, the largest subunit of TFIID. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jun 2010]

TAF6 Products (10)

mRNA	Protein	Name
NM_001190415.2	NP_001177344.1	transcription initiation factor TFIID subunit 6 isoform epsilon
NM_001364998.1	NP_001351927.1	transcription initiation factor TFIID subunit 6 isoform alpha
NM_001364999.1	NP_001351928.1	transcription initiation factor TFIID subunit 6 isoform alpha
NM_001365000.1	NP_001351929.1	transcription initiation factor TFIID subunit 6 isoform delta
NM_001365001.1	NP_001351930.1	transcription initiation factor TFIID subunit 6 isoform delta
NM_001365002.1	NP_001351931.1	transcription initiation factor TFIID subunit 6 isoform delta
NM_001365003.1	NP_001351932.1	transcription initiation factor TFIID subunit 6 isoform delta
NM_001365004.1	NP_001351933.1	transcription initiation factor TFIID subunit 6 isoform zeta
NM_005641.4	NP_005632.1	transcription initiation factor TFIID subunit 6 isoform alpha
NM_139315.3	NP_647476.1	transcription initiation factor TFIID subunit 6 isoform alpha

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables DNA binding	IDA IDA: Inferred from direct assay	15601843	GOA
contributes to RNA polymerase II general transcription initiation factor activity	IDA IDA: Inferred from direct assay	9603525	GOA
enables RNA polymerase II general transcription initiation factor activity	IDA IDA: Inferred from direct assay	15328371	GOA
enables aryl hydrocarbon receptor binding	IPI IPI: Inferred from physical interaction	15641800	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	7667268	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in DNA-templated transcription initiation	IDA IDA: Inferred from direct assay	9603525	GOA
involved in RNA polymerase II preinitiation complex assembly	IPI IPI: Inferred from physical interaction	27007846	GOA
involved in mRNA transcription by RNA polymerase II	IDA IDA: Inferred from direct assay	17884155	GOA
involved in negative regulation of cell cycle	IDA IDA: Inferred from direct assay	15328371	GOA
involved in negative regulation of cell population proliferation	IDA IDA: Inferred from direct assay	15328371	GOA
involved in positive regulation of apoptotic process	IDA IDA: Inferred from direct assay	11583621	GOA
involved in positive regulation of intrinsic apoptotic signaling pathway	IDA IDA: Inferred from direct assay	20096117	GOA
involved in positive regulation of transcription initiation by RNA polymerase II	IDA IDA: Inferred from direct assay	11583621	GOA
involved in regulation of transcription by RNA polymerase II	IDA IDA: Inferred from direct assay	9603525	GOA
involved in transcription initiation at RNA polymerase II promoter	IDA IDA: Inferred from direct assay	9603525	GOA

Cellular Component GO Annotation	Evidence	References	Source
part of MLL1 complex	IDA IDA: Inferred from direct assay	15960975	GOA
located in nucleus	EXP EXP: Inferred from Experiment	23332750	GOA
located in nucleus	IDA IDA: Inferred from direct assay	18628956	GOA
part of protein-containing complex	IMP IMP: Inferred from mutant phenotype	15641800	GOA
part of transcription factor TFIID complex	IDA IDA: Inferred from direct assay	8262073	GOA
part of transcription factor TFIID complex	IPI IPI: Inferred from physical interaction	23332750	GOA
part of transcription factor TFTC complex	IDA IDA: Inferred from direct assay	9603525	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

TAF6 Protein Structure

TAF

TAF6_C

0
200
400
600
677 a.a.

Protein Preferred Names	Protein Names
transcription initiation factor TFIID subunit 6	RNA polymerase II TBP-associated factor subunit E

TAF6 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Cross	TAF6	P49848	PB1	Influenza A virus	Q1K9H5	Pull Down	21994455

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases	Alias
Alazami-Yuan Syndrome	ALYUS
Cornelia De Lange Syndrome	De Lange Syndrome Brachmann De Lange Syndrome Brachmann-De Lange Syndrome Cdls Bdls Typus Degenerativus Amstelodamensis
Cornelia De Lange Syndrome 1	De Lange Syndrome CDLS1 Cdl Cdls Typus Degenerativus Amstelodamensis Brachmann-De Lange Syndrome Bdls Amstelodamensis Typus Degenerativus Cornelia De Lange Syndrome, Type 1
Syndromic Intellectual Disability
Trichohepatoenteric Syndrome 1	Trichohepatoenteric Syndrome Syndromic Diarrhea Tricho-Hepato-Enteric Syndrome Sd/The Syndromic Diarrhea/Tricho-Hepato-Enteric Syndrome THES1 Phenotypic Diarrhea Thes Phenotypic Diarrhea Of Infancy Diarrhea, Syndromic Diarrhea, Fatal Infantile, With Trichorrhexis Nodosa Intractable Diarrhea With Phenotypic Anomalies Syndromatic Diarrhea Fatal Infantile Diarrhea With Trichorrhexis Nodosa
Dystonia 3, Torsion, X-Linked	X-Linked Dystonia-Parkinsonism DYT3 Xdp Lubag Dystonia-Parkinsonism, X-Linked Torsion Dystonia-Parkinsonism, Filipino Type Dyt-Taf1 X-Linked Dystonia-Parkinsonism Syndrome X-Linked Torsion Dystonia-Parkinsonism Syndrome Dystonia Musculorum Deformans X-Linked Dystonia-Parkinsonism/Lubag Lubag Syndrome Dystonia-3 Torsion Dystonia-Parkinsonism Filipino Type X-Linked Torsion Dystonia 3 Dystonia, Torsion, X-Linked, Type 3
Kbg Syndrome	KBGS Macrodontia, Mental Retardation, Characteristic Facies, Short Stature, And Skeletal Anomalies Short Stature, Characteristic Facies, Macrodontia, Intellectual Disability, And Skeletal Anomalies Short Stature, Characteristic Facies, Macrodontia, Mental Retardation, And Skeletal Anomalies Short Stature-Characteristic Facies-Mental Retardation-Macrodontia-Skeletal Anomalies Syndrome Short Stature-Facial And Skeletal Anomalies-Intellectual Disability-Macrodontia Syndrome
Microcephaly	Microencephaly Microcephalus Microcephalic Nanocephaly Congenital Microcephaly Brain Hypoplasia Brain Nondevelopment Cephalic Hypoplasia Undeveloped Cerebrum Undeveloped Brain Micrencephalon Micrencephaly

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (2)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS14173	TAF6 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS14174	TAF6L Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Canis familiaris	TAF6	VGNC	VGNC:47085
Felis catus	TAF6	VGNC	VGNC:65935
Bos taurus	TAF6	VGNC	VGNC:35577
Macaca mulatta	TAF6	VGNC	VGNC:78093
Mus musculus	TAF6	MGD	MGI:109129
Rattus norvegicus	TAF6	RGD	RGD:1311608
Others	TAF6	NCBI