TSPAN8 - tetraspanin 8 Gene

Homo sapiens

Also known as CO-029; TM4SF3

Gene ID: 7103 | Gene type: protein coding

About TSPAN8

Cytogenetic location: 12q21.1 Genomic coordinates (GRCh38): 12:71,125,096-71,157,999 (from NCBI)

This gene has 7 transcripts (splice variants), 217 orthologues and 32 paralogues. Biased expression in colon (RPKM 463.8), duodenum (RPKM 388.7) and 5 other tissues.

Summary

The protein encoded by this gene is a member of the transmembrane 4 superfamily, also known as the tetraspanin family. Most of these members are cell-surface proteins that are characterized by the presence of four hydrophobic domains. The proteins mediate signal transduction events that play a role in the regulation of cell development, activation, growth and motility. This encoded protein is a cell surface glycoprotein that is known to complex with integrins. This gene is expressed in different carcinomas. The use of alternate polyadenylation sites has been found for this gene. [provided by RefSeq, Jul 2008]

TSPAN8 Products(2)

mRNA	Protein	Name
NM_001369760.1	NP_001356689.1	tetraspanin-8
NM_004616.3	NP_004607.1	tetraspanin-8

TSPAN8 Protein Structure

Tetraspannin

0
100
200
237 a.a.

Protein Preferred Names

Protein Names

tetraspanin-8

transmembrane 4 superfamily member 3

Recombinant TSPAN8 Proteins

Cat. No.	Product Name	Accession	Purity
HY-P76117	TSPAN8 Protein, Human (HEK293, His)	P19075 (K110-N205)	≥95%
HY-P76118	TSPAN8 Protein, Human (HEK293, Fc)	P19075 (K110-N205)	≥95%

Related Diseases

Diseases

Alias

Pancreas, Annular

Annular Pancreas	Pancreas Annulare
Congenital Annular Pancreas

Diabetes Mellitus

Diabetes

Maturity-Onset Diabetes Of The Young

MODY	Maturity Onset Diabetes Mellitus In Young
Mason-Type Diabetes	Mason Type Diabetes
Maturity Onset Diabetes Of The Young	Mody Syndrome
Diabetes Of The Young, Maturity-Onset

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS15174	TSPAN8 Human Pre-designed siRNA Set A		/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Mus musculus	TSPAN8	MGD	MGI:2384918
Macaca mulatta	TSPAN8	VGNC	VGNC:78563
Canis familiaris	TSPAN8	VGNC	VGNC:47925
Bos taurus	TSPAN8	VGNC	VGNC:36442
Rattus norvegicus	TSPAN8	RGD	RGD:621783
Others	TSPAN8	NCBI

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