GPR137B - G protein-coupled receptor 137B Gene

Also Known as TM7SF1

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 7107

About GPR137B

Cytogenetic location: 1q42.3 Genomic coordinates (GRCh38): 1:236,142,539-236,208,907 (from NCBI)

This gene has 5 transcripts (splice variants), 259 orthologues and 2 paralogues. Ubiquitous expression in kidney (RPKM 12.9), brain (RPKM 8.4) and 23 other tissues.

Summary

Involved in several processes, including positive regulation of TORC1 signaling; positive regulation of protein localization to lysosome; and regulation of GTPase activity. Located in lysosomal membrane. [provided by Alliance of Genome Resources, Apr 2022]

GPR137B Products (1)

mRNA Protein Name
NM_003272.4 NP_003263.1 integral membrane protein GPR137B
Protein Preferred Names Protein Names

integral membrane protein GPR137B

  • transmembrane 7 superfamily member 1 (upregulated in kidney)

GPR137B Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
GPR137B O60478 TRIM32 Homo sapiens Q13049
Validated Y2H
32296183
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases Alias
Retinitis Pigmentosa 60

  • RP60

  • Retinitis Pigmentosa, Type 60
Ceroid Lipofuscinosis, Neuronal, 1

  • Neuronal Ceroid Lipofuscinosis 1

  • CLN1

  • Infantile Neuronal Ceroid Lipofuscinosis

  • Cln1 Disease

  • Santavuori-Haltia Disease

  • Ceroid Lipofuscinosis, Neuronal, 1, Variable Age At Onset

  • Neuronal Ceroid Lipofuscinosis 1 Variable Age Of Onset

  • Ceroid Lipofuscinosis Neuronal 1

  • Cln1 Variable Age At Onset

  • Infantile Batten Disease

  • Neuronal Ceroid Lipofuscinosis, Infantile

  • Hagberg-Santavuori Disease

  • Incl

  • Juvenile Neuronal Ceroid Lipofuscinosis With Granular Osmiophilic Deposits

  • Neuronal Ceroid Lipofuscinosis With Variable Age At Onset

  • Santavuori Disease

  • Lipofuscinosis, Ceroid, Neuronal, Type 1

  • Ceroid Lipofuscinosis, Neuronal 1, Infantile
Isolated Growth Hormone Deficiency, Type Ib

  • Isolated Growth Hormone Deficiency Type Ib

  • IGHD1B

  • Ighd Ib

  • Growth Hormone Deficiency, Isolated, Type Ib

  • Congenital Ighd Type Ib

  • Congenital Isolated Gh Deficiency Type Ib

  • Congenital Isolated Growth Hormone Deficiency Type Ib

  • Dwarfism Of Sindh

  • Pituitary Dwarfism I

  • Isolated Growth Hormone Deficiency Type 1b

  • Ighd 1b

  • Growth Hormone Deficiency, Isolated, 1b
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS05659 GPR137B Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Mus musculus GPR137B MGD MGI:1891463
Macaca mulatta GPR137B VGNC VGNC:72930
Felis catus GPR137B VGNC VGNC:62673
Bos taurus GPR137B VGNC VGNC:29551
Rattus norvegicus GPR137B RGD RGD:1307342
Canis familiaris GPR137B VGNC VGNC:41398
Others GPR137B NCBI