Bcor - BCL6 interacting corepressor Gene

Also Known as BcorR; mKIAA1575; 2900008C10Rik; 5830466J11Rik; 8430401K06Rik; D930024N20Rik

Species: Mus musculus

Gene Type: protein coding
Gene ID: 71458

Summary

Enables RNA polymerase II transcription regulatory region sequence-specific DNA binding activity and transcription corepressor activity. Acts upstream of or within blastocyst hatching and negative regulation of transcription by RNA polymerase II. Located in nucleus. Is expressed in several structures, including alimentary system; central nervous system; eye; gonad; and lung. Human ortholog(s) of this gene implicated in colorectal cancer; stomach cancer; stomach carcinoma; syndromic microphthalmia 1; and syndromic microphthalmia 2. Orthologous to human BCOR (BCL6 corepressor). [provided by Alliance of Genome Resources, Apr 2022]

Bcor Products (5)

mRNA Protein Name
NM_001168321.1 NP_001161793.1 BCL-6 corepressor isoform d
NM_029510.3 NP_083786.2 BCL-6 corepressor isoform a
NM_175044.3 NP_778209.2 BCL-6 corepressor isoform b
NM_175045.3 NP_778210.2 BCL-6 corepressor isoform c
NM_175046.3 NP_778211.2 BCL-6 corepressor isoform d

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables RNA polymerase II transcription regulatory region sequence-specific DNA binding IDA
IDA: Inferred from direct assay
25331958 MGI
enables protein binding IPI
IPI: Inferred from physical interaction
12522145 MGI
enables transcription corepressor activity IPI
IPI: Inferred from physical interaction
12776190 MGI
Biological Process GO Annotation Evidence References Source
acts upstream of or within blastocyst hatching IMP
IMP: Inferred from mutant phenotype
27869233 MGI
acts upstream of or within negative regulation of transcription by RNA polymerase II IDA
IDA: Inferred from direct assay
12776190 MGI
acts upstream of or within negative regulation of transcription by RNA polymerase II IGI
IGI: Inferred from genetic interaction
25331958 MGI
Cellular Component GO Annotation Evidence References Source
located in nucleus IDA
IDA: Inferred from direct assay
12776190 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

BCL-6 corepressor

Bcor Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
Bcor Q8CGN4 Bcl6 Mus musculus P41183
Anti Bait CoIP
25490446
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (4)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-P10566 BCOR(498-514), biotinylated Inhibitor / Unkown
HY-RS01448 BCOR Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS21299 Bcor Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS27818 Bcor Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Bcor NCBI NCBI:54880