TPP2 - tripeptidyl peptidase 2 Gene

Also Known as IMD78; TPP-2; TPPII; TPP-II

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 7174

About TPP2

Cytogenetic location: 13q33.1 Genomic coordinates (GRCh38): 13:102,596,986-102,679,958 (from NCBI)

This gene has 29 transcripts (splice variants), 196 orthologues, 9 paralogues and is associated with 3 phenotypes. Ubiquitous expression in testis (RPKM 27.4), thyroid (RPKM 15.8) and 25 other tissues.

Summary

This gene encodes a mammalian peptidase that, at neutral pH, removes tripeptides from the N terminus of longer peptides. The protein has a specialized function that is essential for some MHC class I antigen presentation. The protein is a high molecular mass serine exopeptidase; the amino acid sequence surrounding the serine residue at the active site is similar to the peptidases of the subtilisin class rather than the trypsin class. [provided by RefSeq, Jul 2008]

TPP2 Products (3)

mRNA	Protein	Name
NM_001330588.2	NP_001317517.1	tripeptidyl-peptidase 2 isoform 2
NM_001367947.1	NP_001354876.1	tripeptidyl-peptidase 2 isoform 3
NM_003291.4	NP_003282.2	tripeptidyl-peptidase 2 isoform 1

Gene Ontology

Molecular Function
Biological Process

Molecular Function GO Annotation	Evidence	References	Source
enables aminopeptidase activity	EXP EXP: Inferred from Experiment	9668046	GOA
enables aminopeptidase activity	IMP IMP: Inferred from mutant phenotype	25525876	GOA
enables identical protein binding	IPI IPI: Inferred from physical interaction	22483107	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	25416956	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in intracellular amino acid homeostasis	IMP IMP: Inferred from mutant phenotype	25525876	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

TPP2 Protein Structure

Peptidase_S8

TPPII

0
200
400
600
800
1000
1249 a.a.

Protein Preferred Names	Protein Names
tripeptidyl-peptidase 2	tripeptidyl aminopeptidase

TPP2 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	TPP2	P29144	POLB	Homo sapiens	P06746	Y2H Array	25416956
Intra	TPP2	P29144	EHHADH	Homo sapiens	Q08426	Y2H Array	31515488
Intra	TPP2	P29144	EHHADH	Homo sapiens	Q08426	Y2H Prey Pooling	25416956
Intra	TPP2	P29144	POLB	Homo sapiens	P06746	Y2H Prey Pooling	25416956
Intra	TPP2	P29144	EHHADH	Homo sapiens	Q08426	Validated Y2H	25416956
Intra	TPP2	P29144	PPP1R16A	Homo sapiens	Q96I34	Y2H Array	25416956
Intra	TPP2	P29144	EHHADH	Homo sapiens	Q08426	Y2H Array	25416956
Intra	TPP2	P29144	POLB	Homo sapiens	P06746	Y2H Array	31515488

Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant TPP2 Proteins

Cat. No.	Product Name	Accession	Purity
HY-P71451	TPP2 Protein, Human (Myc, His)	P29144 (D44-H264)	≥ 90%, as determined by reducing SDS-PAGE.

TPP2 Antibodies

Cat. No.	Product Name	Application	Reactivity
HY-P810769	TPP2 Antibody (YA10012)	WB, IHC-P, ICC/IF, FC	Human, Mouse, Rat

Related Diseases

Diseases	Alias
Immunodeficiency 78 With Autoimmunity And Developmental Delay	IMD78 Tpp2 Deficiency Autoimmune Hemolytic Anemia-Autoimmune Thrombocytopenia-Primary Immunodeficiency Syndrome Evans Syndrome Associated With Primary Immunodeficiency Tppii Deficiency Tppii-Related Immunodeficiency, Autoimmunity, And Neurodevelopmental Delay With Impaired Glycolysis And Lysosomal Expansion Disease Triangle Disease Tripeptidyl-Peptidase Ii Deficiency
Thrombocytopenia	Low Platelet Count Low Platelets Decreased Platelets Platelet Dysfunction Nos
Evans' Syndrome	Evans Syndrome Autoimmune Hemolytic Anemia And Autoimmune Thrombocytopenia Evan Syndrome Immune Pancytopenia Evan'S Syndrome
Herpetic Whitlow	Herpetic Felon
Hemolytic Anemia	Anemia, Hemolytic Anemia Hemolytic Anaemia Due To Other Disorders Of Glutathione Metabolism Chronic Non Spherocytic Anaemia G6pd - [Glucose-6-Phosphate Dehydrogenase Deficiency] Anaemia Anaemia Due To Glucose-6-Phosphate Dehydrogenase Deficiency Glucose-6-Phosphate Dehydrogenase Deficiency With Anaemia Glucose-6-Phosphate Dehydrogenase Deficiency Anaemia Favism Anaemia Haemolytic Anaemia Due Tog6pd Deficiency Favism Pentose Phosphate Pathway Disorder Anaemia Anaemia Due To Pentose Phosphate Pathway Defect
Ras-Associated Autoimmune Leukoproliferative Disorder	RALD Autoimmune Lymphoproliferative Syndrome Type 4 Alps4 Autoimmune Lymphoproliferative Syndrome, Type Iv Ras-Associated Autoimmune Leukoproliferative Disease Ras-Associated Autoimmune Lymphoproliferative Syndrome Type Iv, Somatic Alps Type 4 Alps Type Iv Autoimmune Lymphoproliferative Syndrome Type Iv Autoimmune Lymphoproliferative Syndrome 4
Epidermodysplasia Verruciformis 1	Epidermodysplasia Verruciformis Epidermodysplasia Verruciformis, Susceptibility To, 1 Lutz-Lewandowsky Epidermodysplasia Verruciformis EV1 Lewandowsky-Lutz Syndrome Ev

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS14943	TPP2 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS18977	Tpp2 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS25466	Tpp2 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Canis familiaris	TPP2	VGNC	VGNC:47748
Felis catus	TPP2	VGNC	VGNC:66481
Mus musculus	TPP2	MGD	MGI:102724
Bos taurus	TPP2	VGNC	VGNC:36257
Macaca mulatta	TPP2	VGNC	VGNC:78637
Rattus norvegicus	TPP2	RGD	RGD:621584
Others	TPP2	NCBI