TRPC4 - transient receptor potential cation channel subfamily C member 4 Gene

Also Known as TRP4; HTRP4; HTRP-4

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 7223

About TRPC4

Cytogenetic location: 13q13.3 Genomic coordinates (GRCh38): 13:37,632,063-37,869,772 (from NCBI)

This gene has 10 transcripts (splice variants), 279 orthologues and 5 paralogues. Biased expression in endometrium (RPKM 6.2), prostate (RPKM 2.5) and 8 other tissues.

Summary

This gene encodes a member of the canonical subfamily of transient receptor potential cation channels. The encoded protein forms a non-selective calcium-permeable cation channel that is activated by Gq-coupled receptors and tyrosine kinases, and plays a role in multiple processes including endothelial permeability, vasodilation, neurotransmitter release and cell proliferation. Single nucleotide polymorphisms in this gene may be associated with generalized epilepsy with photosensitivity. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Aug 2011]

TRPC4 Products (9)

mRNA	Protein	Name
NM_001135955.3	NP_001129427.1	short transient receptor potential channel 4 isoform beta
NM_001135956.3	NP_001129428.1	short transient receptor potential channel 4 isoform gamma
NM_001135957.3	NP_001129429.1	short transient receptor potential channel 4 isoform delta
NM_001135958.3	NP_001129430.1	short transient receptor potential channel 4 isoform zeta
NM_001354799.2	NP_001341728.1	short transient receptor potential channel 4 isoform eta
NM_001354806.2	NP_001341735.1	short transient receptor potential channel 4 isoform eta
NM_001372055.1	NP_001358984.1	short transient receptor potential channel 4 isoform eta
NM_003306.3	NP_003297.1	short transient receptor potential channel 4 isoform epsilon
NM_016179.4	NP_057263.1	short transient receptor potential channel 4 isoform alpha

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables beta-catenin binding	IPI IPI: Inferred from physical interaction	19996314	GOA
enables cadherin binding	IPI IPI: Inferred from physical interaction	19996314	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	15757897	GOA
enables store-operated calcium channel activity	IMP IMP: Inferred from mutant phenotype	16254212	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in calcium ion import	IDA IDA: Inferred from direct assay	19996314	GOA

Cellular Component GO Annotation	Evidence	References	Source
located in basolateral plasma membrane	IDA IDA: Inferred from direct assay	19996314	GOA
part of calcium channel complex	IDA IDA: Inferred from direct assay	20164195	GOA
located in cell surface	IDA IDA: Inferred from direct assay	19996314	GOA
colocalizes with cell-cell junction	IDA IDA: Inferred from direct assay	19996314	GOA
located in cortical cytoskeleton	IDA IDA: Inferred from direct assay	16254212	GOA
located in plasma membrane	IDA IDA: Inferred from direct assay	16254212	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

TRPC4 Protein Structure

Ank_2

Ank

TRP_2

Ion_trans

0
200
400
600
800
977 a.a.

Protein Preferred Names	Protein Names
short transient receptor potential channel 4	trp-related protein 4

TRPC4 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	TRPC4	Q9UBN4	MX1	Homo sapiens	P20591	Anti Tag CoIP	15757897

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases	Alias
Mutilating Palmoplantar Keratoderma With Periorificial Keratotic Plaques	Olmsted Syndrome Mutilating Palmoplantar Hyperkeratosis With Periorificial Keratotic Plaques Palmoplantar And Periorificial Keratoderma Olms
Oculoectodermal Syndrome	Aplasia Cutis Congenita With Epibulbar Dermoids Toriello-Lacassie-Droste Syndrome Oculoectodermal Syndrome, Somatic OES Aplasia Cutis Congenita-Epibulbar Dermoids Syndrome Oculo-Ectodermal Syndrome Toriello Lacassie Droste Syndrome
Darier-White Disease	Keratosis Follicularis Darier Disease Darier'S Disease DAR DD Darier White Disease Darier Disease Acral Hemorrhagic Type Darier Disease Segmental Darier Disease, Acral Hemorrhagic Type Darier Disease, Segmental
Epilepsy	Epilepsy Syndrome Epileptic Syndrome Epilepsies Symptomatic Epilepsies Post Traumatic Epilepsy Traumatic Epilepsy Traumatic Epileptic Epilepsy Due To Hippocampal Sclerosis Epilepsy With Ammon'S Horn Sclerosis Epilepsy Due To Cortical Dysplasia Epilepsy Due To Neuronal Migration Disorders
Immunodeficiency 10	Immune Dysfunction With T-Cell Inactivation Due To Calcium Entry Defect 2 Combined Immunodeficiency Due To Stim1 Deficiency IMD10 Stim1 Deficiency Cid Due To Stim1 Deficiency Immune Dysfunction, With T-Cell Inactivation Due To Calcium Entry Defect 2 Immunodeficiency, Type 10
T Cell And Nk Cell Immunodeficiency
Photosensitive Epilepsy	Pse Photogenic Epilepsy Photoparoxysmal Response Reflex Epilepsy, Photosensitive Photoparoxysmal Response 1
Autosomal Dominant Polycystic Kidney Disease	Polycystic Kidney Disease, Adult Type Adpkd Polycystic Kidney Diseases Polycystic Kidney, Autosomal Dominant Congenital Biliary Ectasias Polycystic Kidney And Hepatic Disease 1 Polycystic Kidney Disease, Autosomal Dominant Kidney, Polycystic, Disease, Autosomal Dominant Adult Polycystic Kidney Disease Polycystic Kidney, Adult Type Apckd - [Autosomal Polycystic Kidney Disease]

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (8)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-133168	Englerin A	Activator	99.50%	Unkown
HY-12949	ML204	Inhibitor	98.45%	Unkown
HY-12949A	ML204 hydrochloride	Inhibitor	99.74%	Unkown
HY-184164	JD03-02	Antagonist	/	Unkown
HY-146155	TRPC4/5-IN-1	Inhibitor	/	Unkown
HY-144429	TRPC5-IN-4	Inhibitor	/	Unkown
HY-173024	TRPC4/5-IN-3	Inhibitor	99.65%	Unkown
HY-162090	TRPC antagonist 1	Antagonist	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Bos taurus	TRPC4	VGNC	VGNC:36383
Mus musculus	TRPC4	MGD	MGI:109525
Canis familiaris	TRPC4	VGNC	VGNC:47868
Macaca mulatta	TRPC4	VGNC	VGNC:106307
Rattus norvegicus	TRPC4	RGD	RGD:621276
Felis catus	TRPC4	VGNC	VGNC:66583
Others	TRPC4	NCBI