Als2 - alsin Rho guanine nucleotide exchange factor Gene

Also Known as Alsin; Als2cr6; mKIAA1563; 3222402C23Rik; 9430073A21Rik

Species: Mus musculus

Gene Type: protein coding

Gene ID: 74018

Summary

Predicted to enable several functions, including GTPase regulator activity; protein homodimerization activity; and small GTPase binding activity. Acts upstream of or within several processes, including behavioral fear response; glutamatergic synaptic transmission; and receptor recycling. Located in several cellular components, including centrosome; lamellipodium; and ruffle. Is expressed in several structures, including central nervous system; genitourinary system; hemolymphoid system; liver; and retina. Human ortholog(s) of this gene implicated in amyotrophic lateral sclerosis and amyotrophic lateral sclerosis type 2. Orthologous to human ALS2 (alsin Rho guanine nucleotide exchange factor ALS2). [provided by Alliance of Genome Resources, Apr 2022]

Als2 Products (3)

mRNA	Protein	Name
NM_001159948.2	NP_001153420.2	alsin isoform 1
NM_028717.6	NP_082993.4	alsin isoform 1
NM_146109.3	NP_666221.1	alsin isoform 2

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables protein binding	IPI IPI: Inferred from physical interaction	17093100	MGI

Biological Process GO Annotation	Evidence	References	Source
acts upstream of or within behavioral fear response	IMP IMP: Inferred from mutant phenotype	16107644	MGI
acts upstream of or within endosomal transport	IMP IMP: Inferred from mutant phenotype	16321985	MGI
acts upstream of or within locomotory behavior	IMP IMP: Inferred from mutant phenotype	16107644	MGI
acts upstream of or within neuromuscular junction development	IMP IMP: Inferred from mutant phenotype	16321985	MGI
acts upstream of or within protein localization	IMP IMP: Inferred from mutant phenotype	17093100	MGI
acts upstream of or within receptor recycling	IMP IMP: Inferred from mutant phenotype	17093100	MGI
acts upstream of or within regulation of GTPase activity	IDA IDA: Inferred from direct assay	16085057	MGI
involved in regulation of postsynaptic membrane neurotransmitter receptor levels	IDA IDA: Inferred from direct assay	17093100	MGI
involved in regulation of postsynaptic membrane neurotransmitter receptor levels	IEP IEP: Inferred from expression pattern	17093100	MGI
involved in regulation of postsynaptic membrane neurotransmitter receptor levels	IMP IMP: Inferred from mutant phenotype	17093100	MGI
acts upstream of or within response to oxidative stress	IMP IMP: Inferred from mutant phenotype	16107644	MGI
acts upstream of or within synaptic transmission, glutamatergic	IMP IMP: Inferred from mutant phenotype	17093100	MGI
acts upstream of or within vesicle organization	IDA IDA: Inferred from direct assay	16085057	MGI

Cellular Component GO Annotation	Evidence	References	Source
located in centrosome	IDA IDA: Inferred from direct assay	16085057	MGI
located in cytoplasm	IDA IDA: Inferred from direct assay	16085057	MGI
located in dendritic spine	IDA IDA: Inferred from direct assay	17093100	MGI
is active in glutamatergic synapse	IDA IDA: Inferred from direct assay	17093100	MGI
is active in glutamatergic synapse	IEP IEP: Inferred from expression pattern	17093100	MGI
is active in glutamatergic synapse	IMP IMP: Inferred from mutant phenotype	17093100	MGI
located in lamellipodium	IDA IDA: Inferred from direct assay	15033976	MGI
is active in postsynaptic density	IDA IDA: Inferred from direct assay	17093100	MGI
located in postsynaptic density	IDA IDA: Inferred from direct assay	17093100	MGI
is active in postsynaptic density	IMP IMP: Inferred from mutant phenotype	17093100	MGI
located in ruffle	IDA IDA: Inferred from direct assay	15033976	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names	Protein Names
alsin	amyotrophic lateral sclerosis 2 (juvenile) homolog amyotrophic lateral sclerosis 2 protein homolog amyotrophic lateral sclerosis protein 2 homolog

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (5)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-W611371A	FP802 dihydrochloride	Inhibitor	99.84%	Unkown
HY-RS00634	ALS2 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS00635	ALS2CL Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS17942	Als2 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS24413	Als2 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Als2	NCBI	NCBI:57679