Ddit4 - DNA-damage-inducible transcript 4 Gene

Also Known as dig2; REDD1; Rtp801; 5830413E08Rik

Species: Mus musculus

Gene Type: protein coding
Gene ID: 74747

Summary

Enables 14-3-3 protein binding activity. Involved in intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator. Acts upstream of or within several processes, including cellular response to dexamethasone stimulus; negative regulation of TOR signaling; and negative regulation of glycolytic process. Located in mitochondrion. Is expressed in reproductive system and retina nuclear layer. Orthologous to human DDIT4 (DNA damage inducible transcript 4). [provided by Alliance of Genome Resources, Apr 2022]

Ddit4 Products (1)

mRNA Protein Name
NM_029083.2 NP_083359.1 DNA damage-inducible transcript 4 protein

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables 14-3-3 protein binding IDA
IDA: Inferred from direct assay
18198340 MGI
Biological Process GO Annotation Evidence References Source
acts upstream of or within cellular response to dexamethasone stimulus IDA
IDA: Inferred from direct assay
17556672 MGI
involved in intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator IMP
IMP: Inferred from mutant phenotype
21896779 MGI
acts upstream of or within negative regulation of TOR signaling IMP
IMP: Inferred from mutant phenotype
18198340 MGI
acts upstream of or within negative regulation of glycolytic process IMP
IMP: Inferred from mutant phenotype
20176937 MGI
acts upstream of or within protein-containing complex disassembly IMP
IMP: Inferred from mutant phenotype
18198340 MGI
acts upstream of or within reactive oxygen species metabolic process IMP
IMP: Inferred from mutant phenotype
20176937 MGI
acts upstream of or within response to hypoxia IMP
IMP: Inferred from mutant phenotype
18198340 MGI
Cellular Component GO Annotation Evidence References Source
located in mitochondrion IDA
IDA: Inferred from direct assay
20176937 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

DNA damage-inducible transcript 4 protein

  • HIF-1 responsive RTP801

  • HIF-1 responsive protein RTP801

  • REDD-1

  • dexamethasone-induced gene 2 protein

  • protein regulated in development and DNA damage response 1

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (4)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS03615 DDIT4 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS16246 Ddit4 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS03616 DDIT4L Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS23835 Ddit4 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Ddit4 NCBI NCBI:54541