Cul5 - cullin 5 Gene

Also Known as VACM1; VACM-1; 4921514I20Rik; 8430423K24Rik; C030032G03Rik; C330021I08Rik

Species: Mus musculus

Gene Type: protein coding
Gene ID: 75717

Summary

Predicted to enable ubiquitin protein Ligase binding activity and ubiquitin-protein transferase activity. Acts upstream of or within cerebral cortex radially oriented cell migration; protein ubiquitination; and radial glia guided migration of Purkinje cell. Predicted to be located in several cellular components, including nucleus; plasma membrane; and site of DNA damage. Predicted to be part of Cul5-RING ubiquitin Ligase complex and SCF ubiquitin Ligase complex. Is expressed in several structures, including brain; eye; genitourinary system; gut; and limb bud. Orthologous to human CUL5 (cullin 5). [provided by Alliance of Genome Resources, Apr 2022]

Cul5 Products (2)

mRNA Protein Name
NM_001161618.2 NP_001155090.2 cullin-5 isoform 2
NM_027807.4 NP_082083.3 cullin-5 isoform 1

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
15601820 MGI
enables ubiquitin ligase complex scaffold activity IMP
IMP: Inferred from mutant phenotype
17974915 MGI
Biological Process GO Annotation Evidence References Source
acts upstream of or within cerebral cortex radially oriented cell migration IMP
IMP: Inferred from mutant phenotype
24210661 MGI
involved in proteasome-mediated ubiquitin-dependent protein catabolic process IMP
IMP: Inferred from mutant phenotype
17974915 MGI
acts upstream of or within protein ubiquitination IGI
IGI: Inferred from genetic interaction
24210661 MGI
acts upstream of or within radial glia guided migration of Purkinje cell IMP
IMP: Inferred from mutant phenotype
24210661 MGI
acts upstream of negative effect reelin-mediated signaling pathway IMP
IMP: Inferred from mutant phenotype
17974915 MGI
involved in regulation of neuron migration IMP
IMP: Inferred from mutant phenotype
17974915 MGI
Cellular Component GO Annotation Evidence References Source
part of Cul5-RING ubiquitin ligase complex IMP
IMP: Inferred from mutant phenotype
17974915 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

cullin-5

  • CUL-5

  • vasopressin-activated calcium-mobilizing receptor protein

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS03364 CUL5 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS20711 Cul5 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS27222 Cul5 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Cul5 NCBI NCBI:8065