Smurf1 - SMAD specific E3 ubiquitin protein ligase 1 Gene

Also Known as mKIAA1625; 4930431E10Rik

Species: Mus musculus

Gene Type: protein coding
Gene ID: 75788

Summary

Predicted to enable I-SMAD binding activity; R-SMAD binding activity; and ubiquitin protein Ligase activity. Involved in parkin-mediated stimulation of Mitophagy in response to mitochondrial depolarization. Acts upstream of or within negative regulation of ossification and protein ubiquitination. Predicted to be located in axon; neuronal cell body; and plasma membrane. Predicted to be active in cytoplasm. Predicted to colocalize with mitochondrion. Is expressed in several structures, including alimentary system; cardiovascular system; central nervous system; genitourinary system; and respiratory system. Orthologous to human SMURF1 (SMAD specific E3 ubiquitin protein Ligase 1). [provided by Alliance of Genome Resources, Apr 2022]

Smurf1 Products (2)

mRNA Protein Name
NM_001038627.1 NP_001033716.1 E3 ubiquitin-protein ligase SMURF1 isoform 1
NM_029438.3 NP_083714.3 E3 ubiquitin-protein ligase SMURF1 isoform 2

Gene Ontology

  • Molecular Function
  • Biological Process
Molecular Function GO Annotation Evidence Références Source
enables protein binding IPI
IPI: Inferred from physical interaction
22020285 MGI
Biological Process GO Annotation Evidence Références Source
acts upstream of or within negative regulation of ossification IMP
IMP: Inferred from mutant phenotype
15820682 MGI
acts upstream of or within protein ubiquitination IMP
IMP: Inferred from mutant phenotype
15820682 MGI
involved in type 2 mitophagy IMP
IMP: Inferred from mutant phenotype
22020285 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

E3 ubiquitin-protein ligase SMURF1

  • HECT-type E3 ubiquitin transferase SMURF1

  • Smad ubiquitination regulatory factor 1

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (12)
Cat. No. Nom du produit
Effect
Pureté
Rare Diseases
HY-110195 Smurf1-IN-A01 99.81% Unkown
HY-P5522A TriDAP dihydrochloride 99.16% Unkown
HY-149316 Smurf1-IN-1 Inhibitor 99.47% Unkown
HY-160928 Smurf1 modulator-1 Inhibitor 99.76% Unkown
HY-169049 Smurf1 ligand 1 99.31% Unkown
HY-W998345 SMART1 Inhibitor 99.87% Unkown
HY-174416 Smurf1-IN-5 Inhibitor 99.01% Unkown
HY-157195 Smurf-1-IN-3 Inhibitor / Unkown
HY-P5522 TriDAP / Unkown
HY-RS13459 SMURF1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS18717 Smurf1 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS25204 Smurf1 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Smurf1 NCBI NCBI:57154