Smurf-1-IN-3
Smurf-1-IN-3 is a selective Smurf-1 inhibitor with an IC50 value of 2.2 nM. Smurf-1-IN-3 can be used for the research of pulmonary arterial hypertension.
For research use only. We do not sell to patients.
- CAS No.: 1825312-08-0
- Formula: C25H27F3N4O4
- Molecular Weight:504.50
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
Smurf-1-IN-3 (Compound 45) (45 min) potently inhibits recombinant Smurf-1 autoubiquitinylation with an IC50 of 2.2 nM[1].
Smurf-1-IN-3 (6.75 nM-22.5 μM) stabilizes Smurf-1 protein in tetracycline-inducible HEK293 cells, confirming cellular inhibition of Smurf-1 activity[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 1825312-08-0
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Molecular Weight 504.50
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Formula C25H27F3N4O4
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SMILES
O=C(C1=NOC2=C1CCCC3=C2C=CC(OC(F)(F)F)=C3)NC4=C(C)N(C)N(C5CCCCC5)C4=O
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Smurf-1-IN-3 Related Classifications
HY-157195 Related Classifications
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