Nuak1 - NUAK family, SNF1-like kinase, 1 Gene

Also Known as Omphk1; B230104P22Rik

Species: Mus musculus

Gene Type: protein coding
Gene ID: 77976

About Nuak1

Chromosome 10: 84,206,769-84,276,461 reverse strand.GRCm39:CM001003.3

This gene has 2 transcripts (splice variants), 257 orthologues, 19 paralogues and is associated with 3 phenotypes. Broad expression in CNS E14 (RPKM 1.9), CNS E18 (RPKM 1.8) and 24 other tissues.

Summary

Predicted to enable p53 binding activity and protein serine/threonine kinase activity. Predicted to be involved in several processes, including cellular response to glucose starvation; regulation of cellular senescence; and regulation of myosin-light-chain-phosphatase activity. Predicted to act upstream of or within cell adhesion; cellular response to DNA damage stimulus; and phosphorylation. Predicted to be located in fibrillar center; microtubule cytoskeleton; and nucleoplasm. Predicted to be active in cytoplasm. Is expressed in several structures, including alimentary system; embryo ectoderm; nervous system; nose; and urinary system. Orthologous to human NUAK1 (NUAK family kinase 1). [provided by Alliance of Genome Resources, Apr 2022]

Nuak1 Products (1)

mRNA Protein Name
NM_001004363.2 NP_001004363.1 NUAK family SNF1-like kinase 1

Nuak1 Protein Structure

STKc_NUAK

STKc_NUAK: cd14073 (53 - 306)

  • 0
  • 200
  • 400
  • 600
  • 658 a.a.
Protein Preferred Names Protein Names

NUAK family SNF1-like kinase 1

  • AMPK-related protein kinase 5

  • ZNUAK family, SNF1-like kinase, 1

  • omphalocele kinase 1

Related Agents

  • Clinical Phase
  • Pre-clinical Phase

Clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Phase
HY-12624 Narazaciclib Inhibitor 98.66% Phase 1

Pre-clinical Phase

Bioactive Molecules (9)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-12334 HTH-01-015 Inhibitor 99.10% Unkown
HY-15802 WZ4003 Inhibitor 98.22% Unkown
HY-120877 MRT199665 Inhibitor 99.85% Unkown
HY-153103 LRRK2/NUAK1/TYK2-IN-1 Inhibitor / Unkown
HY-153058 LRRK2-IN-8 Inhibitor / Unkown
HY-182743 OICR19451 Inhibitor / Unkown
HY-178171 ARUK2010489 Inhibitor 96.64% Unkown
HY-182361 NUAK1-IN-3 Inhibitor / Unkown
HY-178168 ARUK2010694 Inhibitor / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Nuak1 NCBI NCBI:9891