NUAK1
NUAK1, also called ARK5, is an AMPK-related kinase activated by LKB1 and further stimulated downstream of insulin-like growth factor and AKT signaling. It phosphorylates the myosin phosphatase targeting subunit MYPT1, accelerating stress fiber turnover and regulating cell adhesion, and it supports tumor cell survival under nutrient deprivation, invasion, and metastasis. In the nervous system, genetic studies in Drosophila and mice implicate NUAK1 in synaptic transmission and neuronal maintenance. The kinase has emerged as a vulnerability in several cancer models, and the selective inhibitor WZ4003 has been used extensively to dissect NUAK1-dependent phenotypes, supporting continued interest in NUAK1 as a therapeutic target in oncology and neuromuscular research.
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NUAK1 Recombinant Proteins (1)
- Species:
- Source:
Recombinant Protein Expression Service
- Codon Optimization
- Gene Synthesis
- Construction of Expression Vector
- Strain Screening
- Protein Expression
- Purification & QC
- Protein Delivery
- Formula: Human
- Molecular Weight: Sf9 insect cells
The EpCAM/TROP1 protein serves as an important homogeneous interacting molecule that promotes direct contact between intestinal epithelial cells (IEC) and intraepithelial lymphocytes (IEL) in the mucosal epithelium. This feature helps establish an immune barrier against mucosal infections. EpCAM/TROP1 Protein, Human (His-SUMO) is the recombinant human-derived EpCAM/TROP1 protein, expressed by E. coli , with N-6*His, N-SUMO labeled tag.
