COLEC11 - collectin subfamily member 11 Gene

Also Known as 3MC2; CLK1; CL-11; CL-K1-I; CL-K1-II; CL-K1-IIa; CL-K1-IIb

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 78989

About COLEC11

Cytogenetic location: 2p25.3 Genomic coordinates (GRCh38): 2:3,595,112-3,644,644 (from NCBI)

This gene has 13 transcripts (splice variants), 198 orthologues, 4 paralogues and is associated with 3 phenotypes. Biased expression in gall bladder (RPKM 20.2), liver (RPKM 13.5) and 9 other tissues.

Summary

This gene encodes a member of the collectin family of C-type lectins that possess collagen-like sequences and carbohydrate recognition domains. Collectins are secreted proteins that play important roles in the innate immune system by binding to carbohydrate antigens on Microorganisms, facilitating their recognition and removal. The encoded protein binds to multiple sugars with a preference for fucose and mannose. Mutations in this gene are a cause of 3MC syndrome-2. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Dec 2011]

COLEC11 Products (10)

mRNA	Protein	Name
NM_001255982.2	NP_001242911.1	collectin-11 isoform c precursor
NM_001255983.2	NP_001242912.1	collectin-11 isoform d precursor
NM_001255984.2	NP_001242913.1	collectin-11 isoform e precursor
NM_001255985.1	NP_001242914.1	collectin-11 isoform f precursor
NM_001255986.1	NP_001242915.1	collectin-11 isoform g
NM_001255987.1	NP_001242916.1	collectin-11 isoform h
NM_001255988.1	NP_001242917.1	collectin-11 isoform i
NM_001255989.1	NP_001242918.1	collectin-11 isoform j
NM_024027.5	NP_076932.1	collectin-11 isoform a precursor
NM_199235.3	NP_954705.1	collectin-11 isoform b

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables D-mannose binding	IDA IDA: Inferred from direct assay	20956340	GOA
enables DNA binding	IDA IDA: Inferred from direct assay	20956340	GOA
enables calcium ion binding	IDA IDA: Inferred from direct assay	25912189	GOA
enables calcium-dependent carbohydrate binding	IDA IDA: Inferred from direct assay	25912189	GOA
enables fucose binding	IDA IDA: Inferred from direct assay	20956340	GOA
enables identical protein binding	IPI IPI: Inferred from physical interaction	20956340	GOA
enables oligosaccharide binding	IDA IDA: Inferred from direct assay	25912189	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	20956340	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in antimicrobial humoral response	IDA IDA: Inferred from direct assay	20956340	GOA
involved in complement activation	IDA IDA: Inferred from direct assay	23954398	GOA
involved in complement activation, lectin pathway	IDA IDA: Inferred from direct assay	24174618	GOA
involved in complement activation, lectin pathway	IMP IMP: Inferred from mutant phenotype	25912189	GOA
involved in positive regulation of opsonization	IDA IDA: Inferred from direct assay	24174618	GOA
involved in proteolysis	IDA IDA: Inferred from direct assay	24174618	GOA

Cellular Component GO Annotation	Evidence	References	Source
located in extracellular space	IDA IDA: Inferred from direct assay	25912189	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

COLEC11 Protein Structure

Collagen

Lectin_C

0
100
200
271 a.a.

Protein Preferred Names	Protein Names
collectin-11	Collectin K1

COLEC11 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	COLEC11	Q9BWP8	MASP1	Homo sapiens	P48740-1	ELISA	24174618
Intra	COLEC11	Q9BWP8	COLEC10	Homo sapiens	Q9Y6Z7	ELISA	24174618
Intra	COLEC11	Q9BWP8	MASP1	Homo sapiens	P48740	ELISA	20956340
Intra	COLEC11	Q9BWP8	Q9BWP8-PRO_0000315044	Homo sapiens	Q9BWP8-PRO_0000315044	Anti Bait CoIP	24174618
Intra	COLEC11	Q9BWP8	MASP2	Homo sapiens	O00187	ELISA	24174618
Intra	COLEC11	Q9BWP8	COLEC11	Homo sapiens	Q9BWP8	GMS	20956340
Intra	COLEC11	Q9BWP8	MASP1	Homo sapiens	P48740-2	ELISA	24174618
Intra	COLEC11	Q9BWP8	MASP1	Homo sapiens	P48740	Anti Bait CoIP	24174618
Intra	COLEC11	Q9BWP8	COLEC11	Homo sapiens	Q9BWP8	Ion Exchange Chrom	24174618
Intra	COLEC11	Q9BWP8	Q9Y6Z7-PRO_0000314233	Homo sapiens	Q9Y6Z7-PRO_0000314233	Anti Bait CoIP	24174618
Intra	COLEC11	Q9BWP8	Q9BWP8-PRO_0000315044	Homo sapiens	Q9BWP8-PRO_0000315044	Ion Exchange Chrom	24174618
Intra	COLEC11	Q9BWP8	COLEC11	Homo sapiens	Q9BWP8	Comig Non-Denat Gel	20956340
Intra	COLEC11	Q9BWP8	Q9Y6Z7-PRO_0000314233	Homo sapiens	Q9Y6Z7-PRO_0000314233	Ion Exchange Chrom	24174618

Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant COLEC11 Proteins

Cat. No.	Product Name	Accession	Purity
HY-P70100	Collectin-11/CL-K1 Protein, Human (HEK293, His)	Q9BWP8 (Q26-M271)	≥ 95%, as determined by reducing SDS-PAGE.

Related Diseases

Diseases	Alias
3mc Syndrome 2	3MC2 Ptosis Of Eyelids With Diastasis Recti And Hip Dysplasia Oculo-Skeletal-Abdominal Syndrome Osa Syndrome Carnevale Syndrome Carnevale Syndrome, Formerly Carnevale Krajewska Fischetto Syndrome 3mc Syndrome, Type 2
3mc Syndrome	Craniofacial-Ulnar-Renal Syndrome Malpuech Facial Clefting Syndrome Oculopalatoskeletal Syndrome Carnevale Syndrome Michels Syndrome Malpuech-Michels-Mingarelli-Carnevale Syndrome Carnevale-Krajewska-Fischetto Syndrome Craniosynostosis With Lid Anomalies Malpuech Syndrome Mingarelli Syndrome Oculo-Skeletal-Abdominal Syndrome Osa Syndrome Ptosis Of Eyelids With Diastasis Recti And Hip Dysplasia Ptosis-Strabismus-Rectus Abdominis Diastasis
Learning Disability	Learning Disabilities Learning Disorders Academic Skill Disorder Learning Disorder
3mc Syndrome 1	Oculopalatoskeletal Syndrome 3MC1 Craniosynostosis With Lid Anomalies Michels Syndrome, Formerly Michels Syndrome 3mc Syndrome, Type 1
Blepharophimosis
Properdin Deficiency, X-Linked	Properdin Deficiency PFD CFPD Properdin P Factor Deficiency Complement Factor Properdin Deficiency X-Linked Properdin Deficiency Properdin Deficiency, Type I Properdin Deficiency, Type 1 Properdin Deficiency Disease
Van Maldergem Syndrome 1	Cerebrofacioarticular Syndrome VMLDS1 Van Maldergem Syndrome Cerebro-Facio-Articular Syndrome Van Maldergem Wetzburger Verloes Syndrome
Radioulnar Synostosis	Radio-Ulnar Synostosis Type 1
Coffin-Siris Syndrome 9	Mrd27 CSS9 Mental Retardation, Autosomal Dominant 27 Autosomal Dominant Mental Retardation 27 Autosomal Dominant Non-Syndromic Intellectual Disability 27 Coffin-Siris Syndrome, Type 9
Craniosynostosis	Premature Closure Of Cranial Sutures Craniostenosis Craniosynostosis Syndrome Cso Craniosynostoses Congenital Ossification Of Cranial Sutures Congenital Ossification Of Sutures Of Skull Craniostosis Imperfect Fusion Of Skull Congenital Imperfect Closure Skull Imperfect Closure Skull Premature Closure Cranium Sutures Deficiency Of Craniofacial Axis
Urinary Schistosomiasis	Schistosoma Haematobium Infection Schistosoma Hematobium Infection Schistosomiasis Due To Schistosoma Haematobium Bladder Schistosomiasis Cystitis With Bilharziasis Schistosoma Haematobium Schistosoma Hematobium Infectious Disease Schistosomiasis Of Bladder Vesical Schistosomiasis Schistosomiasis Urinary Schistosomiasis Haematobia Genitourinary Bilharziasis Genitourinary Tract Schistosomiasis Schistosomiasis Due To Schistosoma Haematobium [Urinary Schistosomiasis] Haematochyluria In Schistosomiasis Infection Due To Schistosoma Matthei
Angioedema, Hereditary, 1	Hereditary Angioedema Type I Hereditary Angioneurotic Edema Hane C1 Esterase Inhibitor Deficiency Angioedema, Hereditary, 1 And 2 HAE1 Angioneurotic Edema, Hereditary Angioedema, Hereditary, Type I Hereditary Angioedema Type 2 Hae 2 Hae-Ii Hereditary Angioneurotic Edema Type 2 Angioedema, Hereditary HAE Angioedema, Hereditary, Types I And Ii Hereditary Angioedema, Type Ii Angioedema, Hereditary, Type 1 Angioedemas, Hereditary Hereditary C1 Esterase Inhibitor Deficiency - Dysfunctional Factor Hereditary C1 Esterase Inhibitor Deficiency - Deficient Factor Hereditary Angioedema Types I And Ii
Hypertelorism	Eyes Wide Apart Eyes Widely Set Hypertelorism Of Orbit Ocular Hypertelorism Orbital Separation Excessive
Hemolytic Uremic Syndrome, Atypical 1	Atypical Hemolytic-Uremic Syndrome Hemolytic Uremic Syndrome, Atypical, Susceptibility To, 1 Atypical Hemolytic Uremic Syndrome Hemolytic Uremic Syndrome, Atypical, Susceptibility To Ahus AHUS1 Hemolytic-Uremic Syndrome Ahus 1 Ahus, Susceptibility To, 1 Hemolytic Uremic Syndrome, Atypical Non-Shiga-Like Toxin-Associated Hus Non-Stx-Hus Nonenteropathic Hus Atypical Hus Shiga Toxin-Associated Hemolytic Uremic Syndrome D+ Hus Ehec-Hus Hemolytic Uremic Syndrome Associated With Shiga Toxin-Producing Escherichia Coli Hemolytic Uremic Syndrome With Diarrhea Stec-Hus Shiga-Like Toxin-Associated Hus Stx-Hus Typical Hus Typical Hemolytic Uremic Syndrome Atypical Hemolytic Uremic Syndrome With Anti-Factor H Antibodies Atypical Hus With Anti-Factor H Antibodies Ahus With Anti-Factor H Antibodies Ahus With Neutralizing Autoantibodies Against Factor H Hemolytic Uremic Syndrome Atypical 1 Atypical Hemolytic Uremic Syndrome With H Factor Anomaly D Hus Hemolytic-Uremic Syndrome Without Diarrhea Hemolytic-Uremic Syndrome, Atypical, Type 1 Hemolytic Uremic Syndrome, Typical
Orofacial Cleft	Cleft, Orofacial

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS03004	COLEC11 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS18721	Colec11 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS25208	Colec11 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Rattus norvegicus	COLEC11	RGD	RGD:1309678
Bos taurus	COLEC11	VGNC	VGNC:27578
Canis familiaris	COLEC11	VGNC	VGNC:39489
Macaca mulatta	COLEC11	VGNC	VGNC:71194
Felis catus	COLEC11	VGNC	VGNC:61072
Mus musculus	COLEC11	MGD	MGI:1918943
Others	COLEC11	NCBI