ELOVL6 - ELOVL fatty acid elongase 6 Gene

Homo sapiens

Also known as FAE; LCE; FACE; hELO2

Gene ID: 79071 | Gene type: protein coding

About ELOVL6

Cytogenetic location: 4q25 Genomic coordinates (GRCh38): 4:110,045,846-110,199,202 (from NCBI)

This gene has 8 transcripts (splice variants), 233 orthologues and 6 paralogues. Ubiquitous expression in liver (RPKM 11.9), stomach (RPKM 8.9) and 23 other tissues.

Summary

Fatty acid elongases (EC 6.2.1.3), such as ELOVL6, use malonyl-CoA as a 2-carbon donor in the first and rate-limiting step of fatty acid elongation (Moon et al., 2001 [PubMed 11567032]).[supplied by OMIM, Mar 2008]

ELOVL6 Products(2)

mRNA	Protein	Name
NM_001130721.2	NP_001124193.1	elongation of very long chain fatty acids protein 6
NM_024090.3	NP_076995.1	elongation of very long chain fatty acids protein 6

ELOVL6 Protein Structure

ELO

0
100
200
265 a.a.

Protein Preferred Names

Protein Names

elongation of very long chain fatty acids protein 6

3-keto acyl-CoA synthase ELOVL6

Related Diseases

Diseases

Alias

Spinocerebellar Ataxia 38

Spinocerebellar Ataxia Type 38	SCA38
Ataxia, Spinocerebellar, Type 38

Alcohol Dependence

Alcoholism	Alcohol Dependence, Susceptibility To
Alcohol Dependence, Protection Against	Aerodigestive Tract Cancer, Squamous Cell, Alcohol-Related, Protection Against
Alcoholism, Susceptibility To	Alcoholic Intoxication, Chronic
Pharyngeal Neoplasms	Chronic Alcoholism
Dipsomania	Alcohol Addiction
Ethanol Dependence	Chronic Ethanolism
Chronic Alcoholic Disease Nos	Alcoholic Disease Nos
Alcoholic

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (4)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-12146	ELOVL6-IN-2	Inhibitor	99.91%	Unkown
HY-152947	ELOVL6-IN-4		98.63%	Unkown
HY-139451	ELOVL6-IN-3	Inhibitor	≥98.0%	Unkown
HY-RS04326	ELOVL6 Human Pre-designed siRNA Set A		/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Felis catus	ELOVL6	VGNC	VGNC:78485
Canis familiaris	ELOVL6	VGNC	VGNC:40324
Bos taurus	ELOVL6	VGNC	VGNC:28452
Mus musculus	ELOVL6	MGD	MGI:2156528
Rattus norvegicus	ELOVL6	RGD	RGD:620585
Macaca mulatta	ELOVL6	VGNC	VGNC:106568

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