ELOVL6 - ELOVL fatty acid elongase 6 Gene

Also Known as FAE; LCE; FACE; hELO2

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 79071

About ELOVL6

Cytogenetic location: 4q25 Genomic coordinates (GRCh38): 4:110,045,846-110,199,202 (from NCBI)

This gene has 8 transcripts (splice variants), 233 orthologues and 6 paralogues. Ubiquitous expression in liver (RPKM 11.9), stomach (RPKM 8.9) and 23 other tissues.

Summary

Fatty acid elongases (EC 6.2.1.3), such as ELOVL6, use malonyl-CoA as a 2-carbon donor in the first and rate-limiting step of fatty acid elongation (Moon et al., 2001 [PubMed 11567032]).[supplied by OMIM, Mar 2008]

ELOVL6 Products (2)

mRNA Protein Name
NM_001130721.2 NP_001124193.1 elongation of very long chain fatty acids protein 6
NM_024090.3 NP_076995.1 elongation of very long chain fatty acids protein 6

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables fatty acid elongase activity IGI
IGI: Inferred from genetic interaction
26214738 GOA
enables fatty acid elongase activity IMP
IMP: Inferred from mutant phenotype
25003994 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
20937905 GOA
Biological Process GO Annotation Evidence References Source
involved in fatty acid elongation, saturated fatty acid IDA
IDA: Inferred from direct assay
20937905 GOA
involved in fatty acid elongation, saturated fatty acid IGI
IGI: Inferred from genetic interaction
26214738 GOA
involved in long-chain fatty acid biosynthetic process IDA
IDA: Inferred from direct assay
20937905 GOA
Cellular Component GO Annotation Evidence References Source
located in endoplasmic reticulum IDA
IDA: Inferred from direct assay
20937905 GOA
part of fatty acid elongase complex IDA
IDA: Inferred from direct assay
25003994 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

ELOVL6 Protein Structure

ELO

ELO: GNS1/SUR4 family (25 - 261)

  • 0
  • 100
  • 200
  • 265 a.a.
Protein Preferred Names Protein Names

elongation of very long chain fatty acids protein 6

  • 3-keto acyl-CoA synthase ELOVL6

ELOVL6 Antibodies

Cat. No. Product Name Application Reactivity
HY-P810996 ELOVL6/ FACE Antibody WB, ICC/IF Human, Mouse, Rat

Related Diseases

Diseases Alias
Spinocerebellar Ataxia 38

  • Spinocerebellar Ataxia Type 38

  • SCA38

  • Ataxia, Spinocerebellar, Type 38
Alcohol Dependence

  • Alcoholism

  • Alcohol Dependence, Susceptibility To

  • Alcohol Dependence, Protection Against

  • Aerodigestive Tract Cancer, Squamous Cell, Alcohol-Related, Protection Against

  • Alcoholism, Susceptibility To

  • Alcoholic Intoxication, Chronic

  • Pharyngeal Neoplasms

  • Chronic Alcoholism

  • Dipsomania

  • Alcohol Addiction

  • Ethanol Dependence

  • Chronic Ethanolism

  • Chronic Alcoholic Disease Nos

  • Alcoholic Disease Nos

  • Alcoholic
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (8)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-12146 ELOVL6-IN-2 99.91% Unkown
HY-152947 ELOVL6-IN-4 98.94% Unkown
HY-160912 ELOVL6-IN-5 Inhibitor 95.47% Unkown
HY-139451 ELOVL6-IN-3 99.19% Unkown
HY-N11011 Withaphysalin A Inhibitor 98% Unkown
HY-RS04326 ELOVL6 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS18092 Elovl6 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS24566 Elovl6 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Felis catus ELOVL6 VGNC VGNC:78485
Canis familiaris ELOVL6 VGNC VGNC:40324
Bos taurus ELOVL6 VGNC VGNC:28452
Mus musculus ELOVL6 MGD MGI:2156528
Rattus norvegicus ELOVL6 RGD RGD:620585
Macaca mulatta ELOVL6 VGNC VGNC:106568
Others ELOVL6 NCBI